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Cochran–Mantel–Haenszel Statistics
In statistics, the Cochran–Mantel–Haenszel test (CMH) is a test used in the analysis of stratified or matched categorical data. It allows an investigator to test the association between a binary predictor or treatment and a binary outcome such as case or control status while taking into account the stratification. Unlike the McNemar test which can only handle pairs, the CMH test handles arbitrary strata size. It is named after William G. Cochran, Nathan Mantel and William Haenszel. Extensions of this test to a categorical response and/or to several groups are commonly called Cochran–Mantel–Haenszel statistics. It is often used in observational studies where random assignment of subjects to different treatments cannot be controlled, but confounding covariates can be measured. Definition We consider a binary outcome variable such as case status (e.g. lung cancer) and a binary predictor such as treatment status (e.g. smoking). The observations are grouped in strata. The strat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistics
Statistics (from German: '' Statistik'', "description of a state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of surveys and experiments.Dodge, Y. (2006) ''The Oxford Dictionary of Statistical Terms'', Oxford University Press. When census data cannot be collected, statisticians collect data by developing specific experiment designs and survey samples. Representative sampling assures that inferences and conclusions can reasonably extend from the sample to the population as a whole. An ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ben Klemens
Ben Klemens (born April 10, 1975) is an Australian economist, author, and co-host of the podcast 'Pod, Paper, Scissors'. He works for the US Treasury Department and was previously a nonresident fellow at the Brookings Institution's Center on Social and Economic Dynamics. He holds a PhD in Social Sciences from Caltech. Klemens is the author of the proposal to the Unicode consortium for the Falafel emoji, which will be appearing across web platforms in 2019. Statistical computing In the realm of statistical computing, Klemens has done extensive work on statistical analysis for large data sets and non-traditional models such as agent-based models. He developed an innovative library of statistics functions for C, named Apophenia, and has written a textbook on statistical computing, ''Modeling with Data''. Software patent policy Klemens has also worked on the policy aspects of computing, and in particular the issue of software patents. He has argued in a book entitled ''Math Yo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Statistics
Medical statistics deals with applications of statistics to medicine and the health sciences, including epidemiology, public health, forensic medicine, and clinical research. Medical statistics has been a recognized branch of statistics in the United Kingdom for more than 40 years but the term has not come into general use in North America, where the wider term 'biostatistics' is more commonly used.Dodge, Y. (2003) ''The Oxford Dictionary of Statistical Terms'', OUP. However, "biostatistics" more commonly connotes all applications of statistics to biology. Medical statistics is a subdiscipline of statistics. "It is the science of summarizing, collecting, presenting and interpreting data in medical practice, and using them to estimate the magnitude of associations and test hypotheses. It has a central role in medical investigations. It not only provides a way of organizing information on a wider and more formal basis than relying on the exchange of anecdotes and personal experienc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epidemiology
Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare. Epidemiologists help with study design, collection, and statistical analysis of data, amend interpretation and dissemination of results (including peer review and occasional systematic review). Epidemiology has helped develop methodology used in clinical research, public health studies, and, to a lesser extent, basic research in the biological sciences. Major areas of epidemiological study include disease causation, transmission, outbreak investigation, disease surveillance, environmental epidemiology, forensic epidemiology, occupational epidemiology, screening, biomonitoring, and comparisons of treatment effects such as in clinical t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistical Tests For Contingency Tables
Statistics (from German: ''Statistik'', "description of a state, a country") is the discipline that concerns the collection, organization, analysis, interpretation, and presentation of data. In applying statistics to a scientific, industrial, or social problem, it is conventional to begin with a statistical population or a statistical model to be studied. Populations can be diverse groups of people or objects such as "all people living in a country" or "every atom composing a crystal". Statistics deals with every aspect of data, including the planning of data collection in terms of the design of surveys and experiments.Dodge, Y. (2006) ''The Oxford Dictionary of Statistical Terms'', Oxford University Press. When census data cannot be collected, statisticians collect data by developing specific experiment designs and survey samples. Representative sampling assures that inferences and conclusions can reasonably extend from the sample to the population as a whole. An exper ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conditional Logistic Regression
Conditional logistic regression is an extension of logistic regression that allows one to take into account stratification and matching. Its main field of application is observational studies and in particular epidemiology. It was devised in 1978 by Norman Breslow, Nicholas Day, Katherine Halvorsen, Ross L. Prentice and C. Sabai. It is the most flexible and general procedure for matched data. Motivation Observational studies use stratification or matching as a way to control for confounding. Several tests existed before conditional logistic regression for matched data as shown in related tests. However, they did not allow for the analysis of continuous predictors with arbitrary stratum size. All of those procedures also lack the flexibility of conditional logistic regression and in particular the possibility to control for covariates. Logistic regression can take into account stratification by having a different constant term for each stratum. Let us denote Y_\in\ the lab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Score Test
In statistics, the score test assesses constraints on statistical parameters based on the gradient of the likelihood function—known as the ''score''—evaluated at the hypothesized parameter value under the null hypothesis. Intuitively, if the restricted estimator is near the maximum of the likelihood function, the score should not differ from zero by more than sampling error. While the finite sample distributions of score tests are generally unknown, they have an asymptotic χ2-distribution under the null hypothesis as first proved by C. R. Rao in 1948, a fact that can be used to determine statistical significance. Since function maximization subject to equality constraints is most conveniently done using a Lagrangean expression of the problem, the score test can be equivalently understood as a test of the magnitude of the Lagrange multipliers associated with the constraints where, again, if the constraints are non-binding at the maximum likelihood, the vector of Lagrange mu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conditional Logistic Regression
Conditional logistic regression is an extension of logistic regression that allows one to take into account stratification and matching. Its main field of application is observational studies and in particular epidemiology. It was devised in 1978 by Norman Breslow, Nicholas Day, Katherine Halvorsen, Ross L. Prentice and C. Sabai. It is the most flexible and general procedure for matched data. Motivation Observational studies use stratification or matching as a way to control for confounding. Several tests existed before conditional logistic regression for matched data as shown in related tests. However, they did not allow for the analysis of continuous predictors with arbitrary stratum size. All of those procedures also lack the flexibility of conditional logistic regression and in particular the possibility to control for covariates. Logistic regression can take into account stratification by having a different constant term for each stratum. Let us denote Y_\in\ the lab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Smooth Function
In mathematical analysis, the smoothness of a function is a property measured by the number of continuous derivatives it has over some domain, called ''differentiability class''. At the very minimum, a function could be considered smooth if it is differentiable everywhere (hence continuous). At the other end, it might also possess derivatives of all orders in its domain, in which case it is said to be infinitely differentiable and referred to as a C-infinity function (or C^ function). Differentiability classes Differentiability class is a classification of functions according to the properties of their derivatives. It is a measure of the highest order of derivative that exists and is continuous for a function. Consider an open set U on the real line and a function f defined on U with real values. Let ''k'' be a non-negative integer. The function f is said to be of differentiability class ''C^k'' if the derivatives f',f'',\dots,f^ exist and are continuous on U. If f is k-dif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Simpson's Paradox
Simpson's paradox is a phenomenon in probability and statistics in which a trend appears in several groups of data but disappears or reverses when the groups are combined. This result is often encountered in social-science and medical-science statistics, and is particularly problematic when frequency data are unduly given causal interpretations.Judea Pearl. ''Causality: Models, Reasoning, and Inference'', Cambridge University Press (2000, 2nd edition 2009). . The paradox can be resolved when confounding variables and causal relations are appropriately addressed in the statistical modeling. Simpson's paradox has been used to illustrate the kind of misleading results that the misuse of statistics can generate. Edward H. Simpson first described this phenomenon in a technical paper in 1951, but the statisticians Karl Pearson (in 1899) and Udny Yule (in 1903 ) had mentioned similar effects earlier. The name ''Simpson's paradox'' was introduced by Colin R. Blyth in 1972. It is al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stratification (clinical Trials)
Stratification of clinical trials is the partitioning of subjects and results by a factor other than the treatment given. Stratification can be used to ensure equal allocation of subgroups of participants to each experimental condition. This may be done by gender, age, or other demographic factors. Stratification can be used to control for confounding variables (variables other than those the researcher is studying), thereby making it easier for the research to detect and interpret relationships between variables. For example, if doing a study of fitness where age or gender was expected to influence the outcomes, participants could be stratified into groups by the confounding variable. A limitation of this method is that it requires knowledge of what variables need to be controlled. Types of stratification Stratified random sampling designs divide the population into homogeneous strata, and an appropriate number of participants are chosen at random from each stratum. Prop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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