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Charles Yanofsky
Charles Yanofsky (April 17, 1925 – March 16, 2018) was an American geneticist on the faculty of Stanford University who contributed to the establishment of the one gene-one enzyme hypothesis and discovered attenuation, a riboswitch mechanism in which messenger RNA changes shape in response to a small molecule and thus alters its binding ability for the regulatory region of a gene or operon. Education and early life Charles Yanofsky was born on April 17, 1925 in New York. He was one of the earliest graduates of the Bronx High School of Science, then studied at the City College of New York and completed his degree in biochemistry in spite of having had his education interrupted by military service in World War II including participation in the Battle of the Bulge. In 1948, having returned and completed college, he took up graduate work towards his master's degree and PhD, both granted by Yale University. He pursued postdoctoral work at Yale for a time, completing work sta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eli Lilly And Company-Elanco Research Award
The Eli Lilly and Company-Elanco Research Award was a scientific award presented annually by the American Society for Microbiology (ASM) and sponsored by the Eli Lilly and Company and its subsidiary Elanco (which became an independent company in 2019). The prize was first awarded in 1936. Recipients were given 5000 US dollars (as of 2011). It honored young scientists under the age of 45. The award's purpose was not to compare the research of the younger scientists to the research of older scientists, but to encourage originality and independent thinking. The award was discontinued after the last award in 2018. Information about the award can no longer be found on the ASM website. Recipients The following people received the Eli Lilly and Company-Elanco Research Award:{{web archive , url=https://web.archive.org/web/20160611040032/http://www.asm.org/index.php/awards/research/140-awards-a-grants/past-laureates/7791-eli-lilly-and-company-elanco-research-award-past-laureates/ , title=El ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States National Academy Of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM). As a national academy, new members of the organization are elected annually by current members, based on their distinguished and continuing achievements in original research. Election to the National Academy is one of the highest honors in the scientific field. Members of the National Academy of Sciences serve '' pro bono'' as "advisers to the nation" on science, engineering, and medicine. The group holds a congressional charter under Title 36 of the United States Code. Founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln, the NAS is charged with "providing independent, objective advice to the nation on matters related to science and technology. ... to provide scie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California
California is a U.S. state, state in the Western United States, located along the West Coast of the United States, Pacific Coast. With nearly 39.2million residents across a total area of approximately , it is the List of states and territories of the United States by population, most populous U.S. state and the List of U.S. states and territories by area, 3rd largest by area. It is also the most populated Administrative division, subnational entity in North America and the 34th most populous in the world. The Greater Los Angeles area and the San Francisco Bay Area are the nation's second and fifth most populous Statistical area (United States), urban regions respectively, with the former having more than 18.7million residents and the latter having over 9.6million. Sacramento, California, Sacramento is the state's capital, while Los Angeles is the List of largest California cities by population, most populous city in the state and the List of United States cities by population, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Palo Alto
Palo Alto (; Spanish for "tall stick") is a charter city in the northwestern corner of Santa Clara County, California, United States, in the San Francisco Bay Area, named after a coastal redwood tree known as El Palo Alto. The city was established in 1894 by the American industrialist Leland Stanford when he founded Stanford University in memory of his son, Leland Stanford Jr. Palo Alto includes portions of Stanford University and borders East Palo Alto, Mountain View, Los Altos, Los Altos Hills, Stanford, Portola Valley, and Menlo Park. At the 2020 census, the population was 68,572. Palo Alto is one of the most expensive cities in the United States in which to live, and its residents are among the most educated in the country. However, it also has a youth suicide rate four times higher than the national average, often attributed to academic pressure. As one of the principal cities of Silicon Valley, Palo Alto is headquarters to a number of high-tech companies, includi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Riboswitch
In molecular biology, a riboswitch is a regulatory segment of a messenger RNA molecule that binds a small molecule, resulting in a change in production of the proteins encoded by the mRNA. Thus, an mRNA that contains a riboswitch is directly involved in regulating its own activity, in response to the concentrations of its effector molecule. The discovery that modern organisms use RNA to bind small molecules, and discriminate against closely related analogs, expanded the known natural capabilities of RNA beyond its ability to code for proteins, catalyze reactions, or to bind other RNA or protein macromolecules. The original definition of the term "riboswitch" specified that they directly sense small-molecule metabolite concentrations. Although this definition remains in common use, some biologists have used a broader definition that includes other cis-regulatory RNAs. However, this article will discuss only metabolite-binding riboswitches. Most known riboswitches occur in bac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Messenger RNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein. mRNA is created during the process of transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and, utilising amino acids carried by transfer RNA (tRNA), the ribosome creates the protein. This process is known as translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of genetic information in a biological system. As in DNA, genetic inf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Five Prime Untranslated Region
The 5′ untranslated region (also known as 5′ UTR, leader sequence, transcript leader, or leader RNA) is the region of a messenger RNA (mRNA) that is directly upstream from the initiation codon. This region is important for the regulation of translation of a transcript by differing mechanisms in viruses, prokaryotes and eukaryotes. While called untranslated, the 5′ UTR or a portion of it is sometimes translated into a protein product. This product can then regulate the translation of the main coding sequence of the mRNA. In many organisms, however, the 5′ UTR is completely untranslated, instead forming a complex secondary structure to regulate translation. The 5′ UTR has been found to interact with proteins relating to metabolism, and within the 5′ UTR. In addition, this region has been involved in transcription regulation, such as the sex-lethal gene in ''Drosophila''. Regulatory elements within 5′ UTRs have also been linked to mRNA export. General structure Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mitzi Kuroda
Mitzi Kuroda is a professor of genetics at Harvard Medical School and Brigham and Women's Hospital. She was an HHMI Investigator at Brigham and Women's Hospital from 1993 to 2007. She has identified many genes and enzymes involved in epigenetic regulation in the fruit fly. In addition, her research has shown the importance of epigenetics in cancer. Her laboratory has identified chromatin remodeling signals and processes that predispose cells to be transformed into cancer cells. Early life and education Mitzi Kuroda was born in 1958 in Fayetteville, Arkansas, where she attended elementary and junior high schools. She spent a year in Tokyo before returning to attend Fayetteville High School where she graduated as valedictorian in 1977. Mitzi Kuroda said, "When I learned about recombinant DNA in college, it captured my imagination. I had to toss aside all my plans to 'save the world' because the ability to make specific DNA molecules for molecular genetic experiments was just too ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iwona Stroynowski
Iwona Teresa Stroynowski née Fleszar (born 1950) is a Polish-born American immunologist who is Professor in the Department of Immunology and Microbiology at University of Texas Southwestern Medical Center in Dallas, TX. She discovered the process of gene expression control called attenuation early in her career, the first example of a riboswitch mechanism. Early life and education Stroynowski received a PhD from Stanford University in 1979 in the field of Genetics under the supervision of Joshua Lederberg. She became an American citizen in 1982. At Stanford, working with Charles Yanofsky, she discovered the attenuation system regulating bacterial amino acid synthesis pathways. Academic and research career Stroynowski undertook an extended postdoctoral research period with Leroy Hood at California Institute of Technology, during which she changed fields from bacterial genetics to cellular immunology. Then she became an associate professor at University of Texas Southwestern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteria
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic relationsh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DNA Sequence
DNA sequencing is the process of determining the nucleic acid sequence – the order of nucleotides in DNA. It includes any method or technology that is used to determine the order of the four bases: adenine, guanine, cytosine, and thymine. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research and discovery. Knowledge of DNA sequences has become indispensable for basic biological research, DNA Genographic Projects and in numerous applied fields such as medical diagnosis, biotechnology, forensic biology, virology and biological systematics. Comparing healthy and mutated DNA sequences can diagnose different diseases including various cancers, characterize antibody repertoire, and can be used to guide patient treatment. Having a quick way to sequence DNA allows for faster and more individualized medical care to be administered, and for more organisms to be identified and cataloged. The rapid speed of sequencing attained with modern D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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