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Chapare Virus
''Chapare mammarenavirus'' or Chapare virus is a virus from the family '' Arenaviridae'' which causes a hemorrhagic fever in humans known as Chapare hemorrhagic fever. It was first described after an outbreak of a novel zoonotic mammarenavirus infection occurred in the village of Samuzabeti, Chapare Province, Bolivia, in January 2003. A small number of people were infected and one person died. In 2019, nine people became infected with the virus in the La Paz regional area, four of whom died. Nosocomial and human-to-human transmission of the virus occurred in at least three of the cases which resulted in the death of a medical intern and a gastroenterologist. Like other members of the Arenavirus family, the specific zoonotic reservoir and primary transmission vector is suspected to be a rodent, probably the small-eared pygmy rice rat. Virology The Chapare virus is an enveloped virus with a bi-segmented single-stranded ambisense RNA genome. The two RNA segments are denoted Sm ...
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Hemorrhagic Fever
Viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses in which fever and hemorrhage are caused by a viral infection. VHFs may be caused by five distinct families of RNA viruses: the families ''Filoviridae'', ''Flaviviridae'', ''Rhabdoviridae'', and several member families of the ''Bunyavirales'' order such as '' Arenaviridae'', and ''Hantaviridae''. All types of VHF are characterized by fever and bleeding disorders and all can progress to high fever, shock and death in many cases. Some of the VHF agents cause relatively mild illnesses, such as the Scandinavian '' nephropathia epidemica'' (a hantavirus), while others, such as Ebola virus, can cause severe, life-threatening disease. Signs and symptoms Signs and symptoms of VHFs include (by definition) fever and bleeding: * Flushing of the face and chest, small red or purple spots ( petechiae), bleeding, swelling caused by edema, low blood pressure (hypotension), and circulatory shock. * Malaise, mus ...
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Zoonotic
A zoonosis (; plural zoonoses) or zoonotic disease is an infectious disease of humans caused by a pathogen (an infectious agent, such as a bacterium, virus, parasite or prion) that has jumped from a non-human (usually a vertebrate) to a human. Typically, the first infected human transmits the infectious agent to at least one other human, who, in turn, infects others. Major modern diseases such as Ebola virus disease and salmonellosis are zoonoses. HIV was a zoonotic disease transmitted to humans in the early part of the 20th century, though it has now evolved into a separate human-only disease. Most strains of influenza that infect humans are human diseases, although many strains of bird flu and swine flu are zoonoses; these viruses occasionally recombine with human strains of the flu and can cause pandemics such as the 1918 Spanish flu or the 2009 swine flu. ''Taenia solium'' infection is one of the neglected tropical diseases with public health and veterinary concern in ende ...
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Bolivia
, image_flag = Bandera de Bolivia (Estado).svg , flag_alt = Horizontal tricolor (red, yellow, and green from top to bottom) with the coat of arms of Bolivia in the center , flag_alt2 = 7 × 7 square patchwork with the (top left to bottom right) diagonals forming colored stripes (green, blue, purple, red, orange, yellow, white, green, blue, purple, red, orange, yellow, from top right to bottom left) , other_symbol = , other_symbol_type = Dual flag: , image_coat = Escudo de Bolivia.svg , national_anthem = " National Anthem of Bolivia" , image_map = BOL orthographic.svg , map_width = 220px , alt_map = , image_map2 = , alt_map2 = , map_caption = , capital = La Paz Sucre , largest_city = , official_languages = Spanish , languages_type = Co-official languages , languages ...
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La Paz Department (Bolivia)
The La Paz Department of Bolivia comprises with a 2012 census population of 2,706,359 inhabitants. It is situated at the western border of Bolivia, sharing Lake Titicaca with adjacent Peru. It contains the '' Cordillera Real'', which reaches altitudes of . Northeast of the Cordillera Real are the ''Yungas'', the steep eastern slopes of the Andes Mountains that make the transition to the Amazon River basin to the northeast. The capital of the department is the city of La Paz and is the administrative city and seat of government/national capital of Bolivia. Provinces The Department of La Paz is divided into 20 provinces (''provincias'') which are further subdivided into 85 municipalities (''municipios'') and - on the fourth level - into cantons. The provinces with their capitals are: Government The chief executive office of Bolivia's departments (since May 2010) is the Governor; before then, the office was called the Prefect, and until 2006 the prefect was appointed by ...
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Nosocomial
A hospital-acquired infection, also known as a nosocomial infection (from the Greek , meaning "hospital"), is an infection that is acquired in a hospital or other health care facility. To emphasize both hospital and nonhospital settings, it is sometimes instead called a healthcare–associated infection. Such an infection can be acquired in hospital, nursing home, rehabilitation facility, outpatient clinic, diagnostic laboratory or other clinical settings. Infection is spread to the susceptible patient in the clinical setting by various means. Health care staff also spread infection, in addition to contaminated equipment, bed linens, or air droplets. The infection can originate from the outside environment, another infected patient, staff that may be infected, or in some cases, the source of the infection cannot be determined. In some cases the microorganism originates from the patient's own skin microbiota, becoming opportunistic after surgery or other procedures that compromi ...
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Medical Intern
A medical intern is a physician in training who has completed medical school and has a medical degree but does not yet have a license to practice medicine unsupervised. Medical education generally ends with a period of practical training similar to internship, but the way the overall program of academic and practical medical training is structured differs depending upon the country, as does the terminology used (see medical education and medical school for further details). Australia In Australia, medical graduates must complete one year in an accredited hospital post before they receive full registration. This year of conditional registration is called the intern year. An internship is not necessarily completed in a hospital at the same state as the graduate's medical school. Brazil In Brazil, medical school consists of six years or twelve semesters. The final two years (or one and a half years, depending on the University in question) are the internship. During this time, stude ...
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Gastroenterologist
Gastroenterology (from the Greek gastḗr- “belly”, -énteron “intestine”, and -logía "study of") is the branch of medicine focused on the digestive system and its disorders. The digestive system consists of the gastrointestinal tract, sometimes referred to as the ''GI tract,'' which includes the esophagus, stomach, small intestine and large intestine as well as the accessory organs of digestion which includes the pancreas, gallbladder, and liver. The digestive system functions to move material through the GI tract via peristalsis, break down that material via digestion, absorb nutrients for use throughout the body, and remove waste from the body via defecation. Physicians who specialize in the medical specialty of gastroenterology are called gastroenterologists or sometimes ''GI doctors''. Some of the most common conditions managed by gastroenterologists include gastroesophageal reflux disease, gastrointestinal bleeding, irritable bowel syndrome, irritable bowel disease ...
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Vector (epidemiology)
In epidemiology, a disease vector is any living agent that carries and transmits an infectious pathogen to another living organism; agents regarded as vectors are organisms, such as parasites or microbes. The first major discovery of a disease vector came from Ronald Ross in 1897, who discovered the malaria pathogen when he dissected a mosquito. Arthropods Arthropods form a major group of pathogen vectors with mosquitoes, flies, sand flies, lice, fleas, ticks, and mites transmitting a huge number of pathogens. Many such vectors are haematophagous, which feed on blood at some or all stages of their lives. When the insects feed on blood, the pathogen enters the blood stream of the host. This can happen in different ways. The ''Anopheles'' mosquito, a vector for malaria, filariasis, and various arthropod-borne-viruses (arboviruses), inserts its delicate mouthpart under the skin and feeds on its host's blood. The parasites the mosquito carries are usually located in its salivary gla ...
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Rodent
Rodents (from Latin , 'to gnaw') are mammals of the order Rodentia (), which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents. They are native to all major land masses except for New Zealand, Antarctica, and several oceanic islands, though they have subsequently been introduced to most of these land masses by human activity. Rodents are extremely diverse in their ecology and lifestyles and can be found in almost every terrestrial habitat, including human-made environments. Species can be arboreal, fossorial (burrowing), saltatorial/richochetal (leaping on their hind legs), or semiaquatic. However, all rodents share several morphological features, including having only a single upper and lower pair of ever-growing incisors. Well-known rodents include mice, rats, squirrels, prairie dogs, porcupines, beavers, guinea pigs, and hamsters. Rabbits, hares, and pikas, whose i ...
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Small-eared Pygmy Rice Rat
''Oligoryzomys microtis'', also known as the small-eared colilargo or small-eared pygmy rice rat, is a species of rodent in the genus ''Oligoryzomys'' of family Cricetidae. It is found in western Brazil, eastern Peru, Bolivia, and northern Paraguay. Description ''Oligoryzomys microtis'' has a total length of including a tail of . It weighs about and is the smallest species in the genus. In proportion to the head and body length, the hind feet are relatively long, being 28.5% of their length. This compares with the rather similar ''Oligoryzomys nigripes'' where the proportion is 24.5%. The ears are small and densely furred inside. The cheeks may be grey or orangeish-brown. The back is brownish and the underparts are whitish or greyish, sometimes tinged with buff. The tail is rather darker on the upper surface than the lower surface. Its karyotype A karyotype is the general appearance of the complete set of metaphase chromosomes in the cells of a species or in an individual or ...
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