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C102T
In genetics, rs6313 also called T102C or C102T is a gene variation—a single nucleotide polymorphism (SNP)—in the human ''HTR2A'' gene that codes for the 5-HT2A receptor. The SNP is a synonymous substitution located in exon 1 of the gene where it is involved in coding the 34th amino acid as serine. As 5-HT2A is a neuroreceptor the SNP has been investigated in connection with brain functions and neuropsychiatric disorders, and it is perhaps the most investigated SNP for its gene. Two other SNPs in HTR2A have also received much attention: rs6311 and His452Tyr (rs6314). The T102C polymorphism has been shown to be in complete linkage disequilibrium with the rs6311 (A-1438G). A less well investigated SNP of this gene is rs7997012. Meta-analyses seem to indicate that the SNP is not directly associated with schizophrenia, not with Alzheimer's disease, and two initial studies seem to indicate that it is not associated with Parkinson's disease. There have been multiple stu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HTR2A
The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). The 5-HT2A receptor is a cell surface receptor, but has several intracellular locations. 5-HT is short for 5-hydroxy-tryptamine or serotonin. This is the main excitatory receptor subtype among the GPCRs for serotonin, although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was first noted for its importance as a target of serotonergic psychedelic drugs such as LSD and psilocybin mushrooms. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones. Downregulation of post-synaptic 5-HT2A receptor is an adaptive process provoked by chronic administration of selective serotonin reuptake inhibitors (SSRIs) and atypical antipsychotics. Suicidal and otherwise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
5-HT2A
The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). The 5-HT2A receptor is a cell surface receptor, but has several intracellular locations. 5-HT is short for 5-hydroxy-tryptamine or serotonin. This is the main excitatory receptor subtype among the GPCRs for serotonin, although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbitofrontal cortex. This receptor was first noted for its importance as a target of serotonergic psychedelic drugs such as LSD and psilocybin mushrooms. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones. Downregulation of post-synaptic 5-HT2A receptor is an adaptive process provoked by chronic administration of selective serotonin reuptake inhibitors (SSRIs) and atypical antipsychotics. Suicidal and otherwise ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schizophrenia Research Forum
Schizophrenia Research Forum is a web knowledge environment dedicated to news, information resources, and discussion about research on schizophrenia. It hosts a number of resources such as What We Know About Schizophrenia, Animal Models and Drugs in Trials. It also hosts the ''SzGene'' database, an unbiased field synopsis of genetic association studies performed in schizophrenia, though this database is no longer updated. The Schizophrenia Forum was founded in 2005 by science editor Hakon Heimer as a project of the National Alliance for Research on Schizophrenia and Depression (now called the Brain & Behavior Research Foundation, with start-up funding from the National Institute of Mental Health and technical assistance from the Alzheimer Research Forum Alzheimer Research Forum (ARF), or Alzforum is a website which uses web technology to accelerate research into Alzheimer's disease. History The website was founded in 1996 by June Kinoshita, funded by an anonymous philanthropic fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Personality Traits
In psychology, trait theory (also called dispositional theory) is an approach to the study of human personality. Trait theorists are primarily interested in the measurement of ''traits'', which can be defined as habitual patterns of behaviour, thought, and emotion. According to this perspective, traits are aspects of personality that are relatively stable over time, differ across individuals (e.g. some people are outgoing whereas others are not), are relatively consistent over situations, and influence behaviour. Traits are in contrast to states, which are more transitory dispositions. In some theories and systems, traits are something a person either has or does not have, but in many others traits are dimensions such as extraversion vs. introversion, with each person rating somewhere along this spectrum. There are two approaches to define traits: as internal causal properties or as purely descriptive summaries. The internal causal definition states that traits influence our behav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenotypes
In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological properties, its behavior, and the products of behavior. An organism's phenotype results from two basic factors: the expression of an organism's genetic code, or its genotype, and the influence of environmental factors. Both factors may interact, further affecting phenotype. When two or more clearly different phenotypes exist in the same population of a species, the species is called polymorphic. A well-documented example of polymorphism is Labrador Retriever coloring; while the coat color depends on many genes, it is clearly seen in the environment as yellow, black, and brown. Richard Dawkins in 1978 and then again in his 1982 book ''The Extended Phenotype'' suggested that one can regard bird nests and other built structures such as cad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schizophrenia Research
''Schizophrenia Research'' is a peer-reviewed medical journal covering research on the cause, clinical diagnostics, and treatment of schizophrenia. It is an official journal of the Schizophrenia International Research Society and was established in 1988. The editor-in-chief is Matcheri Keshavan and the former editors are Henry Nasrallah (University of Cincinnati) and Lynn DeLisi (Harvard Medical School). According to ''Schizophrenia Researchs original mission statement, the journal is aimed at According to the ''Journal Citation Reports'', the journal has a 2018 impact factor of 4.56 See also * List of psychiatry journals * ''Schizophrenia Bulletin ''Schizophrenia Bulletin'' is a peer-reviewed medical journal which covers research relating to the etiology and treatment of schizophrenia. The journal is published bimonthly by Oxford University Press in association with the Maryland Psychiatric ...'' References External links * {{Official website, https://www.journ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature Genetics
''Nature Genetics'' is a peer-reviewed scientific journal published by Nature Portfolio. It was established in 1992. It covers research in genetics. The chief editor is Tiago Faial. The journal encompasses genetic and functional genomic studies on human traits and on other model organisms, including mouse, fly, nematode and yeast. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. According to the ''Journal Citation Reports'', the journal has a 2021 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 41.379, ranking it 2nd out of 175 journals in the category "Genetics & Heredity". References External links Official websit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Despina G
Despina may refer to: People * Despina Delios, American beauty pageant contestant * Despina Stratigakos (born 1963), Canadian-born architectural historian and academic * Despina Vandi (born 1969), Greek singer * Olivera Despina ( – after 1444), Serbian princess and Ottoman queen consort * Milica Despina of Wallachia ( – 1554), Princess consort of Wallachia Other uses * Despoina, a figure in Greek mythology * ''Despina'' (moth), a genus of moth * Despina (moon), a moon of Neptune * Despina, a character in Mozart's opera ''Così fan tutte'' * "Despoina", a song by Nikos Karvelas Nikos Karvelas ( el, Νίκος Καρβέλας; born Nikos Leonardos on 8 September 1951) is a Greek songwriter, producer and singer. He has sold millions of records as a producer and is most recognizable for his three-decade-long collaborat ... {{Disambiguation, given name Greek feminine given names ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas A
Thomas may refer to: People * List of people with given name Thomas * Thomas (name) * Thomas (surname) * Saint Thomas (other) * Thomas Aquinas (1225–1274) Italian Dominican friar, philosopher, and Doctor of the Church * Thomas the Apostle * Thomas (bishop of the East Angles) (fl. 640s–650s), medieval Bishop of the East Angles * Thomas (Archdeacon of Barnstaple) (fl. 1203), Archdeacon of Barnstaple * Thomas, Count of Perche (1195–1217), Count of Perche * Thomas (bishop of Finland) (1248), first known Bishop of Finland * Thomas, Earl of Mar (1330–1377), 14th-century Earl, Aberdeen, Scotland Geography Places in the United States * Thomas, Illinois * Thomas, Indiana * Thomas, Oklahoma * Thomas, Oregon * Thomas, South Dakota * Thomas, Virginia * Thomas, Washington * Thomas, West Virginia * Thomas County (other) * Thomas Township (other) Elsewhere * Thomas Glacier (Greenland) Arts, entertainment, and media * ''Thomas'' (Burton novel) 1969 nove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Evangelia E
Evangelia is a Greek feminine given name. Notable people with this name include: * Evangelia Atamian, (1922 – 23 February 1957), an Armenian-Greek rebetiko singer, known as Marika Ninou *Evangelia Aravani, Greek fashion model and TV presenter * Evangelia Chantava, Greek volleyball player * Evangelia Chatziefraimoglou, Greek volleyball player *Evangelia Christodoulou, Greek rhythmic gymnast *Evangelia Micheli-Tzanakou, biomedical engineer and professor *Evangelia Moraitidou, Greek water polo player *Evangelia Platanioti, Greek artistic swimmer *Evangelia Psarra Evangelia Psarra ( el, Ευαγγελία Ψάρρα; born June 17, 1974 in Thessaloniki) is a Greek archer who has competed at the Summer Olympics six times from 2000 to 2020. Career At the 2004 Summer Olympics, Psarra entered the women's competi ..., Greek archer * Evangelia Tsagka, Greek swimmer See also * MV ''E Evangelia'', a ship References {{given name Greek feminine given names ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
John P
John is a common English name and surname: * John (given name) * John (surname) John may also refer to: New Testament Works * Gospel of John, a title often shortened to John * First Epistle of John, often shortened to 1 John * Second Epistle of John, often shortened to 2 John * Third Epistle of John, often shortened to 3 John People * John the Baptist (died c. AD 30), regarded as a prophet and the forerunner of Jesus Christ * John the Apostle (lived c. AD 30), one of the twelve apostles of Jesus * John the Evangelist, assigned author of the Fourth Gospel, once identified with the Apostle * John of Patmos, also known as John the Divine or John the Revelator, the author of the Book of Revelation, once identified with the Apostle * John the Presbyter, a figure either identified with or distinguished from the Apostle, the Evangelist and John of Patmos Other people with the given name Religious figures * John, father of Andrew the Apostle and Saint Peter * Pope Joh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
