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Biomolecular Condensate
In biochemistry, biomolecular condensates are a class of membrane-less organelles and organelle subdomains, which carry out specialized functions within the cell. Unlike many organelles, biomolecular condensate composition is not controlled by a bounding membrane. Instead, condensates can form and maintain organization through a range of different processes, the most well-known of which is phase separation of proteins, RNA and other biopolymers into either colloidal emulsions, gels, liquid crystals, solid crystals or aggregates within cells. History Micellar theory The micellar theory of Carl Nägeli was developed from his detailed study of starch granules in 1858. Amorphous substances such as starch and cellulose were proposed to consist of building blocks, packed in a loosely crystalline array to form what he later termed “micelles”. Water could penetrate between the micelles, and new micelles could form in the interstices between old micelles. The swelling of st ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Formation And Examples Of Membraneless Organelles
Formation may refer to: Linguistics * Back-formation, the process of creating a new lexeme by removing or affixes * Word formation, the creation of a new word by adding affixes Mathematics and science * Cave formation or speleothem, a secondary mineral deposit formed in a cave * Class formation, a topological group acting on a module satisfying certain conditions * Formation (group theory), a class of groups that is closed under some operations * Formation constant, an equilibrium constant for the formation of a complex in solution * Formation enthalpy, standard heat of formation of a compound * Formation (group theory), a class of groups * Formation (geology), a formally named rock stratum or geological unit * Formation of rocks, how rocks are formed * Formation and evolution of the Solar System, history of the Solar System * Rock formation, an isolated, scenic, or spectacular surface rock outcrop * Vegetation formation, a concept used to classify vegetation communities Militar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Casein
Casein ( , from Latin ''caseus'' "cheese") is a family of related phosphoproteins (CSN1S1, αS1, aS2, CSN2, β, K-casein, κ) that are commonly found in mammalian milk, comprising about 80% of the proteins in cow's milk and between 20% and 60% of the proteins in breast milk, human milk. Sheep's milk, Sheep and buffalo milk have a higher casein content than other types of milk with human milk having a particularly low casein content. Casein has a wide variety of uses, from being a major component of cheese, to use as a food additive. The most common form of casein is sodium caseinate. In milk, casein undergoes phase separation to form colloidal casein micelles, a type of secreted biomolecular condensate. As a food source, casein supplies amino acids, carbohydrates, and two essential elements, calcium and phosphorus. Composition Casein contains a high number of proline amino acids which hinder the formation of common secondary structural motifs of proteins. There are also no di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coacervate
Coacervate ( or ) is an aqueous phase rich in macromolecules such as synthetic polymers, proteins or nucleic acids. It forms through liquid-liquid phase separation (LLPS), leading to a dense phase in thermodynamic equilibrium with a dilute phase. The dispersed droplets of dense phase are also called coacervates, micro-coacervates or coacervate droplets.These structures draw a lot of interest because they form spontaneously from aqueous mixtures and provide stable compartmentalization without the need of a membrane. The term coacervate was coined in 1929 by Dutch chemist Hendrik G. Bungenberg de Jong and Hugo R. Kruyt while studying lyophilic colloidal dispersions. The name is a reference to the clustering of colloidal particles, like ''bees in a swarm''. The concept was later borrowed by Russian biologist Alexander I. Oparin to describe the proteinoid microspheres proposed to be primitive cells (protocells) on early Earth. Coacervate-like protocells are at the core of the Oparin-H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexander Oparin
Alexander Ivanovich Oparin (russian: Александр Иванович Опарин; – April 21, 1980) was a Soviet biochemist notable for his theories about the origin of life, and for his book ''The Origin of Life''. He also studied the biochemistry of material processing by plants and enzyme reactions in plant cells. He showed that many food production processes were based on biocatalysis and developed the foundations for industrial biochemistry in the USSR. Life Born in Uglich in 1894, Oparin graduated from the Moscow State University in 1917 and became a professor of biochemistry there in 1927. Many of his early papers were about plant enzymes and their role in metabolism. In 1924 he put forward a hypothesis suggesting that life on Earth developed through a gradual chemical evolution of carbon-based molecules in the Earth's primordial soup. In 1935, along with academician Alexey Bakh, he founded the Biochemistry Institute of the Soviet Academy of Sciences. In 1939, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Primordial Soup
Primordial soup, also known as, primordial goo, primordial ooze, prebiotic soup and prebiotic broth, is the hypothetical set of conditions present on the Earth around 3.7 to 4.0 billion years ago. It is an aspect of the heterotrophic theory (also known as the Oparin–Haldane hypothesis) concerning the origin of life, first proposed by Alexander Oparin in 1924, and J. B. S. Haldane in 1929. As formulated by Oparin, in the primitive Earth's surface layers, carbon, hydrogen, water vapour, and ammonia reacted to form the first organic compounds. The concept of a primordial soup gained credence in 1953 when the "Miller–Urey experiment" used a highly reduced mixture of gases—methane, ammonia and hydrogen—to form basic organic monomers, such as amino acids. Historical background The notion that living beings originated from inanimate materials comes from the Ancient Greeks—the theory known as spontaneous generation. Aristotle in the 4th century BCE gave a proper explanation, wri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stephane Leduc
Stephane may refer to: * Stéphane Stéphane is a male French given name an equivalent of Stephen/Steven. Notable people with this given name include: * Stéphane Adam (born 1969), French footballer *Stéphane Agbre Dasse (born 1989), Burkinabé football player *Stéphane Allagnon, ..., a French given name * Stephane (Ancient Greece), a vestment in ancient Greece * Stephane (Paphlagonia), a town of ancient Paphlagonia, now in Turkey {{dab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Colloid
A colloid is a mixture in which one substance consisting of microscopically dispersed insoluble particles is suspended throughout another substance. Some definitions specify that the particles must be dispersed in a liquid, while others extend the definition to include substances like aerosols and gels. The term colloidal suspension refers unambiguously to the overall mixture (although a narrower sense of the word ''suspension'' is distinguished from colloids by larger particle size). A colloid has a dispersed phase (the suspended particles) and a continuous phase (the medium of suspension). The dispersed phase particles have a diameter of approximately 1 nanometre to 1 micrometre. Some colloids are translucent because of the Tyndall effect, which is the scattering of light by particles in the colloid. Other colloids may be opaque or have a slight color. Colloidal suspensions are the subject of interface and colloid science. This field of study was introduced in 1845 by Itali ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Globulins
The globulins are a family of globular proteins that have higher molecular weights than albumins and are insoluble in pure water but dissolve in dilute salt solutions. Some globulins are produced in the liver, while others are made by the immune system. Globulins, albumins, and fibrinogen are the major blood proteins. The normal concentration of globulins in human blood is about 2.6-3.5 g/dL. The term "globulin" is sometimes used synonymously with "globular protein". However, albumins are also globular proteins, but are ''not'' globulins. All other serum globular proteins are globulins. Types of globulins All globulins fall into one of the following three categories : * Alpha globulins * Beta globulins * Gamma globulins (one group of gamma globulins is the immunoglobulins, which are also known as "antibodies") Globulins can be distinguished from one another using serum protein electrophoresis. Globulins exert oncotic pressure. Their deficiency results in loss of carrier funct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleolus
The nucleolus (, plural: nucleoli ) is the largest structure in the nucleus of eukaryotic cells. It is best known as the site of ribosome biogenesis, which is the synthesis of ribosomes. The nucleolus also participates in the formation of signal recognition particles and plays a role in the cell's response to stress. Nucleoli are made of proteins, DNA and RNA, and form around specific chromosomal regions called nucleolar organizing regions. Malfunction of nucleoli can be the cause of several human conditions called "nucleolopathies" and the nucleolus is being investigated as a target for cancer chemotherapy. History The nucleolus was identified by bright-field microscopy during the 1830s. Little was known about the function of the nucleolus until 1964, when a study of nucleoli by John Gurdon and Donald Brown in the African clawed frog ''Xenopus laevis'' generated increasing interest in the function and detailed structure of the nucleolus. They found that 25% of the frog e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas Harrison Montgomery Jr
Thomas may refer to: People * List of people with given name Thomas * Thomas (name) * Thomas (surname) * Saint Thomas (other) * Thomas Aquinas (1225–1274) Italian Dominican friar, philosopher, and Doctor of the Church * Thomas the Apostle * Thomas (bishop of the East Angles) (fl. 640s–650s), medieval Bishop of the East Angles * Thomas (Archdeacon of Barnstaple) (fl. 1203), Archdeacon of Barnstaple * Thomas, Count of Perche (1195–1217), Count of Perche * Thomas (bishop of Finland) (1248), first known Bishop of Finland * Thomas, Earl of Mar (1330–1377), 14th-century Earl, Aberdeen, Scotland Geography Places in the United States * Thomas, Illinois * Thomas, Indiana * Thomas, Oklahoma * Thomas, Oregon * Thomas, South Dakota * Thomas, Virginia * Thomas, Washington * Thomas, West Virginia * Thomas County (other) * Thomas Township (other) Elsewhere * Thomas Glacier (Greenland) Arts, entertainment, and media * ''Thomas'' (Burton novel) 1969 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protoplasm
Protoplasm (; ) is the living part of a cell that is surrounded by a plasma membrane. It is a mixture of small molecules such as ions, monosaccharides, amino acid, and macromolecules such as proteins, polysaccharides, lipids, etc. In some definitions, it is a general term for the cytoplasm (e.g., Mohl, 1846), but for others, it also includes the nucleoplasm (e.g., Strasburger, 1882). For Sharp (1921), "According to the older usage the extra-nuclear portion of the protoplast 'the entire cell, excluding the cell wall''was called "protoplasm," but the nucleus also is composed of protoplasm, or living substance in its broader sense. The current consensus is to avoid this ambiguity by employing Strasburger's '(1882)''terms cytoplasm Albert_von_Kölliker.html"_;"title="'coined_by_Albert_von_Kölliker">Kölliker_(1863),_originally_as_synonym_for_protoplasm''and_nucleoplasm_([''term_coined_by_Edouard_Van_Beneden.html" ;"title="Albert von Kölliker">Kölliker (1863), originally as syn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytoplasm
In cell biology, the cytoplasm is all of the material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus. The material inside the nucleus and contained within the nuclear membrane is termed the nucleoplasm. The main components of the cytoplasm are cytosol (a gel-like substance), the organelles (the cell's internal sub-structures), and various cytoplasmic inclusions. The cytoplasm is about 80% water and is usually colorless. The submicroscopic ground cell substance or cytoplasmic matrix which remains after exclusion of the cell organelles and particles is groundplasm. It is the hyaloplasm of light microscopy, a highly complex, polyphasic system in which all resolvable cytoplasmic elements are suspended, including the larger organelles such as the ribosomes, mitochondria, the plant plastids, lipid droplets, and vacuoles. Most cellular activities take place within the cytoplasm, such as many metabolic pathways including glycolysis, and proces ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
