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Bette Korber
Bette Korber is an American computational biologist focusing on the molecular biology and population genetics of the HIV virus that causes infection and eventually AIDS. She has contributed heavily to efforts to obtain an effective HIV vaccine. She created a database at Los Alamos National Laboratory that has enabled her to design novel mosaic HIV vaccines, one of which is currently in human testing in Africa. The database contains thousands of HIV genome sequences and related data. Korber is a scientist in theoretical biology and biophysics. at Los Alamos National Laboratory. She has received the Ernest Orlando Lawrence Award, the United States Department of Energy, Department of Energy's highest award for scientific achievement. She has also received several other awards including the Elizabeth Glaser Award for pediatric AIDS research and the Richard Feynman Award for Innovation. Early life and education Bette Korber grew up in Southern California. She earned her B.S. in ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zulu People
Zulu people (; zu, amaZulu) are a Nguni ethnic group native to Southern Africa. The Zulu people are the largest ethnic group and nation in South Africa, with an estimated 10–12 million people, living mainly in the province of KwaZulu-Natal. They originated from Nguni communities who took part in the Bantu migrations over millennia. As the clans integrated together, the rulership of Shaka brought success to the Zulu nation due to his improved military tactics and organization. Zulus take pride in their ceremonies such as the Umhlanga, or Reed Dance, and their various forms of beadwork. The art and skill of beadwork takes part in the identification of Zulu people and acts as a form of communication and dedication to the tribe and specific traditions. The men and women both serve different purposes in society in order to function as a whole. Today the Zulu people predominantly believe in Christianity, but have created a syncretic religion that is combined with the Zulu's pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Theoretical Biology
Mathematical and theoretical biology, or biomathematics, is a branch of biology which employs theoretical analysis, mathematical models and abstractions of the living organisms to investigate the principles that govern the structure, development and behavior of the systems, as opposed to experimental biology which deals with the conduction of experiments to prove and validate the scientific theories. The field is sometimes called mathematical biology or biomathematics to stress the mathematical side, or theoretical biology to stress the biological side. Theoretical biology focuses more on the development of theoretical principles for biology while mathematical biology focuses on the use of mathematical tools to study biological systems, even though the two terms are sometimes interchanged. Mathematical biology aims at the mathematical representation and modeling of biological processes, using techniques and tools of applied mathematics. It can be useful in both theoretical and prac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard School Of Public Health
The Harvard T.H. Chan School of Public Health is the public health school of Harvard University, located in the Longwood Medical Area of Boston, Massachusetts. The school grew out of the Harvard-MIT School for Health Officers, the nation's first graduate training program in population health, which was founded in 1913 and then became the Harvard School of Public Health in 1922. Harvard's T.H. Chan School of Public Health is currently ranked as the best school for public health in the world by both the ''Academic Ranking of World Universities'' and EduRank. It is also ranked as the second (tie) best public health school in the nation by '' U.S. News & World Report''. History Harvard's T.H. School of Public Health traces its origins to the Harvard-MIT School for Health Officers, which was founded in 1913. Harvard calls it "the nation's first graduate training program in public health." In 1922, the School for Health Officers became the Harvard School of Public Health. In 1946, it ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HTLV-1
Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, ''Strongyloides stercoralis'' hyper-infection and some other diseases. It is thought that about 1–5% of infected persons develop cancer as a result of the infection with HTLV-I over their lifetimes. Adult T-cell lymphoma (ATL) was discovered in 1977 in Japan. The symptoms of ATL were different from other lymphomas known at the time. It was suggested that ATL is caused by the infection of a retrovirus called ATLV. Strikingly, ATLV had the transforming activity in vitro. These studies established that the retrovirus infection is the cause of ATL. The retrovirus is now generally called HTLV-I because later studies proved that ATLV is the same a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Epidemiology
Molecular epidemiology is a branch of epidemiology and medical science that focuses on the contribution of potential genetic and environmental risk factors, identified at the molecular level, to the etiology, distribution and prevention of disease within families and across populations. This field has emerged from the integration of molecular biology into traditional epidemiological research. Molecular epidemiology improves our understanding of the pathogenesis of disease by identifying specific pathways, molecules and genes that influence the risk of developing disease. More broadly, it seeks to establish understanding of how the interactions between genetic traits and environmental exposures result in disease. History The term "molecular epidemiology" was first coined by Edwin D. Kilbourne in a 1973 article entitled "The molecular epidemiology of influenza". The term became more formalized with the formulation of the first book on ''Molecular Epidemiology: Principles and Prac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myron Essex
Myron Elmer "Max" Essex (born August 17, 1939) is the Mary Woodard Lasker Professor of Health Sciences, emeritus in the Department of Immunology and Infectious Diseases at Harvard University, Chair of the Harvard T.H. Chan School of Public Health AIDS Initiative (HAI) in the Department of Immunology and Infectious Diseases, and Chair of the Botswana–Harvard AIDS Institute in Gaborone, Botswana. Essex was one of the first to link animal and human retroviruses to immunosuppressive disease, to suspect that a retrovirus was the cause of AIDS, and to determine that HIV could be transmitted through blood and blood products to hemophiliacs and recipients of blood transfusions. With collaborators, Essex also provided the first evidence that HIV could be transmitted by heterosexual intercourse. In 1984, Essex identified gp120, the virus surface protein that is used worldwide for blood screening, HIV detection, and epidemiological monitoring. With collaborators, including African mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Interferon
Interferons (IFNs, ) are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses. IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. Interferons are named for their ability to "interfere" with viral replication by protecting cells from virus infections. However, virus-encoded genetic elements have the ability to antagonize the IFN response contributing to viral pathogenesis and viral diseases. IFNs also have various other functions: they activate immune cells, such as natural killer cells and macrophages, and they increase host defenses by up-regulating antigen presentation by virtue of increasing the expression of major histocompatibility complex (M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transplant Rejection
Transplant rejection occurs when Organ transplant, transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant. Types of transplant rejection Transplant rejection can be classified into three types: hyperacute, acute, and chronic. These types are differentiated by how quickly the recipient's immune system is activated and the specific aspect or aspects of immunity involved. Hyperacute rejection Hyperacute rejection is a form of rejection that manifests itself in the minutes to hours following transplantation. It is caused by the presence of pre-existing Antibody, antibodies in the recipient that recognize antigens in the donor organ. These antigens are located on the endothelial lining of blood vessels within the transplanted organ and, once antibodies bind, will lead to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histocompatibility
Histocompatibility, or tissue compatibility, is the property of having the same, or sufficiently similar, alleles of a set of genes called human leukocyte antigens (HLA), or major histocompatibility complex (MHC). Each individual expresses many unique HLA proteins on the surface of their cells, which signal to the immune system whether a cell is part of the self or an invading organism. T cells recognize foreign HLA molecules and trigger an immune response to destroy the foreign cells. Histocompatibility testing is most relevant for topics related to whole organ, tissue, or stem cell transplants, where the similarity or difference between the donor's HLA alleles and the recipient's triggers the immune system to reject the transplant. The wide variety of potential HLA alleles lead to unique combinations in individuals and make matching difficult. Discovery The discovery of the MHC and role of histocompatibility in transplantation was a combined effort of many scientists in the 20t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Regulation Of Gene Expression
Regulation of gene expression, or gene regulation, includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental stimuli, or adapt to new food sources. Virtually any step of gene expression can be modulated, from Transcriptional regulation, transcriptional initiation, to RNA processing, and to the post-translational modification of a protein. Often, one gene regulator controls another, and so on, in a gene regulatory network. Gene regulation is essential for viruses, prokaryotes and eukaryotes as it increases the versatility and adaptability of an organism by allowing the cell to express protein when needed. Although as early as 1951, Barbara McClintock showed interaction between two genetic loci, Activator (''Ac'') and Dissociator (''Ds''), in the color f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
California State University, Long Beach
California State University, Long Beach (CSULB) is a public research university in Long Beach, California. The 322-acre campus is the second largest of the 23-school California State University system (CSU) and one of the largest universities in the state of California by enrollment, its student body numbering 39,435 for the fall 2021 semester. With 5,830 graduate students as of fall 2021, the university enrolls one of the largest graduate student populations across the CSU system and in the state of California. The Beach is home to one of the largest publicly funded art schools in the United States. The university currently operates with one of the lowest student tuition and mandatory fee rates in the country, at $5,742 per semester for full-time students with California residence as of 2021. CSULB is an Hispanic-serving institution (HSI) and is eligible to be designated as an Asian American Native American Pacific Islander serving institution (AANAPISI). History The colleg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during a Chemical reaction, reaction with other Chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the properties ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
