Babycurus Toxin 1
Babycurus-toxin 1 (BcTx1) is a component of the venom of the east African scorpion ''Babycurus centrurimorphus''. This toxin modifies both the activation and the inactivation properties of insect sodium channels. Sources This toxin is a component of the venom secreted by the east African scorpion ''Babycurus centrurimorphus'' of the scorpion family Buthidae, and is more specific in envenoming insects, for example the cockroach, than in human envenoming.Action of babycurus-t ...
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Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily of cation channels and can be classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel; also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. These channels go through three different states called resting, active and inactive states. Even though the resting and inactive states would not allow the ions to flow through the channels the difference exists with respect to their structural conformation. Selectivity Sodium channels are highly selective for the transport of ions across cell membr ...
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