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Brill–Zinsser Disease
Brill–Zinsser disease is a delayed relapse of epidemic typhus, caused by ''Rickettsia prowazekii''. After a patient contracts epidemic typhus from the fecal matter of an infected louse (''Pediculus humanus''), the rickettsia can remain latent and reactivate months or years later, with symptoms similar to or even identical to the original attack of typhus, including a maculopapular rash. At such times, typhus can be transmitted to other individuals through fecal matter of the louse vector, and generate a new epidemic of the disease. See also * Nathan Edwin Brill * Hans Zinsser * Tick-borne lymphadenopathy * List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. The major function of this system is as a barrier against t ... References External links Bacterium-related cutaneous conditions Epidemic typhus [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rickettsia Prowazekii
''Rickettsia prowazekii'' is a species of gram-negative, alphaproteobacteria, obligate intracellular parasitic, aerobic bacillus bacteria that is the etiologic agent of epidemic typhus, transmitted in the feces of lice. In North America, the main reservoir for ''R. prowazekii'' is the flying squirrel. ''R. prowazekii'' is often surrounded by a protein microcapsular layer and slime layer; the natural life cycle of the bacterium generally involves a vertebrate and an invertebrate host, usually an arthropod, typically the human body louse. A form of ''R. prowazekii'' that exists in the feces of arthropods remains stably infective for months. ''R. prowazekii'' also appears to be the closest free-living relative of mitochondria, based on genome sequencing. History Discovery Henrique da Rocha Lima, a Brazilian doctor, discovered this bacterium in 1916. He named it after his colleague Stanislaus von Prowazek, who had died from typhus in 1915. Both Prowazek and Rocha Lima had b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Louse
Louse ( : lice) is the common name for any member of the clade Phthiraptera, which contains nearly 5,000 species of wingless parasitic insects. Phthiraptera has variously been recognized as an order, infraorder, or a parvorder, as a result of developments in phylogenetic research. Lice are obligate parasites, living externally on warm-blooded hosts which include every species of bird and mammal, except for monotremes, pangolins, and bats. Lice are vectors of diseases such as typhus. Chewing lice live among the hairs or feathers of their host and feed on skin and debris, while sucking lice pierce the host's skin and feed on blood and other secretions. They usually spend their whole life on a single host, cementing their eggs, called nits, to hairs or feathers. The eggs hatch into nymphs, which moult three times before becoming fully grown, a process that takes about four weeks. Genetic evidence indicates that lice are a highly modified lineage of Psocoptera (now called Ps ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pediculus Humanus
''Pediculus humanus'' is a species of louse that infects humans. It comprises two subspecies: *''Pediculus humanus humanus'' Linnaeus, 1758 – body louse *''Pediculus humanus capitis'' De Geer, 1767 – head louse The head louse (''Pediculus humanus capitis'') is an obligate ectoparasite of humans. Head lice are wingless insects that spend their entire lives on the human scalp and feeding exclusively on human blood. Humans are the only known hosts of th ... References External links * Lice Insects described in 1758 Parasitic arthropods of humans Taxa named by Carl Linnaeus {{louse-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rickettsia
''Rickettsia'' is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci (0.1 μm in diameter), bacilli (1–4 μm long), or threads (up to about 10 μm long). The term "rickettsia" has nothing to do with rickets (which is a deficiency disease resulting from lack of vitamin D); the bacterial genus ''Rickettsia'' instead was named after Howard Taylor Ricketts, in honor of his pioneering work on tick-borne spotted fever. Properly, ''Rickettsia'' is the name of a single genus, but the informal term "rickettsia", plural "rickettsias", usually not capitalised, commonly applies to any members of the order Rickettsiales. Being obligate intracellular bacteria, rickettsias depend on entry, growth, and replication within the cytoplasm of living eukaryotic host cells (typically endothelial cells). Accordingly, ''Rickettsia'' species cannot grow in artificial nutrient culture; they must be grown either in tissue or embryo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Latency Period
In epidemiology, particularly in the discussion of infectious disease dynamics (modeling), the latent period (also known as the latency period or the pre-infectious period) is the time interval between when an individual or host is infected by a pathogen and when they become infectious, i.e. capable of transmitting pathogens to other susceptible individuals. Relationship with related concepts in infectious disease dynamics To understand the spreading dynamics of an infectious disease or an epidemic, three important time periods should be carefully distinguished: incubation period, pre-infectious or latent period and infectious period. Two other relevant and important time period concepts are generation time and serial interval. The infection of a disease begins when a pathogenic (disease-causing) infectious agent, or a pathogen, is successfully transmitted from one host to another. Pathogens leave the body of one host through a portal of exit, are carried by some mode of trans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maculopapular
A maculopapular rash is a type of rash characterized by a flat, red area on the skin that is covered with small confluent bumps. It may only appear red in lighter-skinned people. The term "maculopapular" is a compound: ''macules'' are small, flat discolored spots on the surface of the skin; and ''papules'' are small, raised bumps. It is also described as erythematous, or red. This type of rash is common in several diseases and medical conditions, including scarlet fever, measles, Ebola virus disease, rubella, secondary syphilis (Congenital syphilis, which is asymptomatic, the newborn may present this type of rash), erythrovirus (parvovirus B19), chikungunya (alphavirus), zika, smallpox (which has been eradicated), varicella (when vaccinated persons exhibit symptoms from the modified form), heat rash, and sometimes in Dengue fever. It is also a common manifestation of a skin reaction to the antibiotic amoxicillin or chemotherapy drugs. Cutaneous infiltration of leukemic cells may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rash
A rash is a change of the human skin which affects its color, appearance, or texture. A rash may be localized in one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, chapped, dry, cracked or blistered, swell, and may be painful. The causes, and therefore treatments for rashes, vary widely. Diagnosis must take into account such things as the appearance of the rash, other symptoms, what the patient may have been exposed to, occupation, and occurrence in family members. The diagnosis may confirm any number of conditions. The presence of a rash may aid diagnosis; associated signs and symptoms are diagnostic of certain diseases. For example, the rash in measles is an erythematous, morbilliform, maculopapular rash that begins a few days after the fever starts. It classically starts at the head, and spreads downwards. Differential diagnosis Common causes of rashes include: * Food allergy * Medication side effects * Anxiet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epidemic
An epidemic (from Ancient Greek, Greek ἐπί ''epi'' "upon or above" and δῆμος ''demos'' "people") is the rapid spread of disease to a large number of patients among a given population within an area in a short period of time. Epidemics of infectious diseases are generally caused by several factors including a significant change in the ecology of the areal population (e.g., increased stress maybe additional reason or increase in the density of a vector species), the introduction of an emerging pathogen to an areal population (by movement of pathogen or host) or an unexpected genetic change that is in the pathogen reservoir. Generally, epidemics concerns with the patterns of infectious disease spread. An epidemic may occur when host immunity to either an established pathogen or newly emerging novel pathogen is suddenly reduced below that found in the endemic equilibrium and the transmission threshold is exceeded. For example, in meningococcal infections, an attack rate in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nathan Edwin Brill
Nathan Edwin Brill (January 3, 1860Some sources give January 13.– December 13, 1925) was an American physician who, while at Mount Sinai Hospital in New York City, discovered Brill-Zinsser disease (or, often, simply Brill's disease), a late relapse of epidemic typhus. Biography Brill was born in New York City and earned his medical degree at New York University College in 1880. He completed his internship at the Bellevue Hospital in 1881. In 1882 he was appointed physician at the Mount Sinai Hospital, later becoming professor at the Columbia University College of Physicians and Surgeons. Brill's medical accomplishments include: * The discovery of Brill-Zinsser disease, the recurrent mild typhus in immigrants from Eastern Europe; Brill determined the disease to be a latent infection after earlier contact with lice or ticks; * The coining (with Frederick S. Mandlebaum) of the term Gaucher's disease and Brill's recognition of it as a lipid storage disease; * Description of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hans Zinsser
Hans Zinsser (November 17, 1878 – September 4, 1940) was an American physician, bacteriologist, and prolific author. The author of over 200 books and medical articles, he was also a published poet. Some of his verses were published in ''The Atlantic Monthly''. "Zinsser, Hans". ''National Cyclopaedia of American Biography''. New York: James T. White Company. 1950. Volume XXXVI, pp. 35-36. His 1940 publication, '' As I Remember Him: the Biography of R.S.'', won one of the early National Book Awards, the sixth and last annual award for Nonfiction voted by members of the American Booksellers Association. "Books and Authors", ''The New York Times'', 1936-04-12, p. BR12. ProQuest Historical Newspapers The New York Times (1851-2007). "Books and Authors", ''The New York Times'', 1941-02-16, p. BR12. ProQuest Historical Newspapers The New York Times (1851-2007). He is remembered especially for his 1935 book, ''Rats, Lice and History''. Biography Early life The son of German imm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tick-borne Lymphadenopathy
Tick-borne lymphadenopathy is infectious disease, an uncommon tick-borne rickettsiosis caused by ''Rickettsia slovaca''. It is transmitted exclusively by the ''Dermacentor marginatus'' tick. It is endemic to parts of east and south Europe. Infection is associated with formation of an eschar at the site of the tick bite, constitutional symptoms (fever and pains), and lymphadenopathy chiefly affecting the neck. A maculopapular rash may sometimes also arise. Epidemiology Presence of ''R. slovaca'' has been documented in Slovakia, Czechia, Ukraine, Russia, Armenia, Switzerland, France, Portugal, as well as others. Serologic evidence of infections has moreover been noted in Germany, Austria, and Lithuania. See also * Epidemic typhus * Brill–Zinsser disease * Rickettsia aeschlimannii infection * List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, na ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
