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Andes Orthohantavirus
''Andes orthohantavirus'' (ANDV), a species of ''Orthohantavirus,'' is a major causative agent of hantavirus cardiopulmonary syndrome (HCPS) and hantavirus pulmonary syndrome (HPS) in South America. It is named for the Andes mountains of Chile and Argentina, where it was first discovered. Originating in the reservoir of rodents, ''Andes orthohantavirus'' is easily transmitted to humans who come into contact with infected rodents or their fecal droppings. However, infected rodents do not appear ill, so there is no readily apparent indicator to determine whether the rodent is infected or not. Additionally, ''Andes orthohantavirus'', specifically, is the only hantavirus that can be spread by human to human contact via bodily fluids or long-term contact from one infected individual to a healthy person. Discovery ''Andes orthohantavirus'' was first identified when outbreaks of this new infection spread throughout Chile and Argentina. In 1995, it was finally characterized in Argentina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orthohantavirus
''Orthohantavirus'' is a genus of single-stranded, enveloped, negative-sense RNA viruses in the family ''Hantaviridae'' within the order ''Bunyavirales''. Members of this genus may be called orthohantaviruses or simply hantaviruses. Orthohantaviruses typically cause chronic asymptomatic infection in rodents. Humans may become infected with hantaviruses through contact with rodent urine, saliva, or feces. Some strains cause potentially fatal diseases in humans, such as hantavirus hemorrhagic fever with renal syndrome (HFRS), or hantavirus pulmonary syndrome (HPS), also known as hantavirus cardiopulmonary syndrome (HCPS), while others have not been associated with known human disease (e.g. Prospect Hill virus). HPS (HCPS) is a "rare respiratory illness associated with the inhalation of aerosolized rodent excreta (urine and feces) contaminated by hantavirus particles." Human infections of hantaviruses have almost entirely been linked to human contact with rodent excrement; however, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cap Snatching
The first step of transcription for some negative, single-stranded RNA viruses is cap snatching, in which the first 10 to 20 residues of a host cell RNA are removed (snatched) and used as the 5′ cap and primer to initiate the synthesis of the nascent viral mRNA. The viral RNA-dependent RNA polymerase (RdRp) can then proceed to replicate the negative-sense genome from the positive-sense template. Cap-snatching also explains why some viral mRNA have 5’ terminal extensions of 10-20 nucleotides that are not encoded for in the genome. Examples of viruses that engage in cap-snatching include influenza viruses ('' Orthomyxoviridae''), Lassa virus ('' Arenaviridae''), hantaan virus (''Hantaviridae'') and rift valley fever virus (''Phenuiviridae''). Most viruses snatch 15-20 nucleotides except for the families ''Arenaviridae'' and ''Nairoviridae'' and the genus Thogotovirus (''Orthomyxoviridae'') which use a shorter strand. In the influenza virus, cap snatching occurs in the nucleus o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sin Nombre Virus
''Sin Nombre orthohantavirus'' (SNV) (from Spanish, meaning "without a name") is the prototypical etiologic agent of hantavirus cardiopulmonary syndrome (HCPS). Discovered in 1993 near the Cañon de la Muerte on the Navajo Reservation, it was originally named the Muerto Canyon hantavirus, in keeping with the convention for naming new pathogens. However, the Navajo Nation objected to the name in 1994. It was also near the Four Corners point in the United States, so the virologists then tried naming it the "Four Corners virus". The name was changed after local residents raised objections. In frustration, the virologists changed it to ''Sin Nombre'', meaning "without a name" in Spanish. History It was first isolated in 1993 from rodents collected near the home of one of the initial patients with hantavirus pulmonary syndrome (HPS) in the Four Corners region of the western United States. Isolation was achieved through a blind passage in ''Peromyscus maniculatus'' (deer mouse) and su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pleural Cavity
The pleural cavity, pleural space, or interpleural space is the potential space between the pleurae of the pleural sac that surrounds each lung. A small amount of serous pleural fluid is maintained in the pleural cavity to enable lubrication between the membranes, and also to create a pressure gradient. The serous membrane that covers the surface of the lung is the visceral pleura and is separated from the outer membrane the parietal pleura by just the film of pleural fluid in the pleural cavity. The visceral pleura follows the fissures of the lung and the root of the lung structures. The parietal pleura is attached to the mediastinum, the upper surface of the diaphragm, and to the inside of the ribcage. Structure In humans, the left and right lungs are completely separated by the mediastinum, and there is no communication between their pleural cavities. Therefore, in cases of a unilateral pneumothorax, the contralateral lung will remain functioning normally unless there is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Syrian Hamster
The golden hamster or Syrian hamster (''Mesocricetus auratus'') is a rodent belonging to the hamster subfamily, Cricetinae. Their natural geographical range is in an arid region of northern Syria and southern Turkey. Their numbers have been declining in the wild due to a loss of habitat from agriculture and deliberate elimination by humans. Thus, wild golden hamsters are now considered endangered by the International Union for Conservation of Nature. However, captive breeding programs are well-established, and captive-bred golden hamsters are often kept as small house pets. Syrian hamsters are larger than many of the dwarf hamsters kept as pocket pets (up to five times larger), and weigh about the same as a sugar glider, though the wild European hamster exceeds Syrian hamsters in size. They are also used as scientific research animals throughout the world. Characteristics The size of adult animals is around long, with a lifespan of 2–3 years. Body mass is usually in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Reservoir
In infectious disease ecology and epidemiology, a natural reservoir, also known as a disease reservoir or a reservoir of infection, is the population of organisms or the specific environment in which an infectious pathogen naturally lives and reproduces, or upon which the pathogen primarily depends for its survival. A reservoir is usually a living host of a certain species, such as an animal or a plant, inside of which a pathogen survives, often (though not always) without causing disease for the reservoir itself. By some definitions a reservoir may also be an environment external to an organism, such as a volume of contaminated air or water. Because of the enormous variety of infectious microorganisms capable of causing disease, precise definitions for what constitutes a natural reservoir are numerous, various, and often conflicting. The reservoir concept applies only for pathogens capable of infecting more than one host population and only with respect to a defined target popula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oligoryzomys
''Oligoryzomys'' is a genus of rodents in the tribe Oryzomyini of family Cricetidae. Many species are known as pygmy rice rats or colilargos.Musser and Carleton, 2005 The genus is found from Mexico to Tierra del Fuego and includes approximately 17 species. In Argentina and Chile, ''Oligoryzomys longicaudatus'' and other members of the genus represent the reservoir for the hantavirus strain Andes virus (ANDV) (Wells et al., 1997; Levis et al., 1998; Cantoni et al., 2001). Taxonomy The genus ''Oligoryzomys'' is included in the subfamily Sigmodontinae of the family Cricetidae. The genus is placed in the Oryzomyini tribe, first proposed by Oldfield Thomas in the early 20th century. It includes genera that have certain dental features of the upper and lower molars and a long palate which extends past the third molars. More recently, molecular analysis and morphological data has placed the genus in Clade C, alongside ''Neacomys'', ''Microryzomys'' and ''Oreoryzomys''. Characteristics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uruguay
Uruguay (; ), officially the Oriental Republic of Uruguay ( es, República Oriental del Uruguay), is a country in South America. It shares borders with Argentina to its west and southwest and Brazil to its north and northeast; while bordering the Río de la Plata to the south and the Atlantic Ocean to the southeast. It is part of the Southern Cone region of South America. Uruguay covers an area of approximately and has a population of an estimated 3.4 million, of whom around 2 million live in the metropolitan area of its capital and largest city, Montevideo. The area that became Uruguay was first inhabited by groups of hunter–gatherers 13,000 years ago. The predominant tribe at the moment of the arrival of Europeans was the Charrúa people, when the Portuguese first established Colónia do Sacramento in 1680; Uruguay was colonized by Europeans late relative to neighboring countries. The Spanish founded Montevideo as a military stronghold in the early 18th century bec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paraguay
Paraguay (; ), officially the Republic of Paraguay ( es, República del Paraguay, links=no; gn, Tavakuairetã Paraguái, links=si), is a landlocked country in South America. It is bordered by Argentina to the south and southwest, Brazil to the east and northeast, and Bolivia to the northwest. It has a population of seven million, nearly three million of whom live in the capital and largest city of Asunción, and its surrounding metro. Although one of only two landlocked countries in South America (Bolivia is the other), Paraguay has ports on the Paraguay and Paraná rivers that give exit to the Atlantic Ocean, through the Paraná-Paraguay Waterway. Spanish conquistadores arrived in 1524, and in 1537, they established the city of Asunción, the first capital of the Governorate of the Río de la Plata. During the 17th century, Paraguay was the center of Jesuit missions, where the native Guaraní people were converted to Christianity and introduced to European culture. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brazil
Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area and the seventh most populous. Its capital is Brasília, and its most populous city is São Paulo. The federation is composed of the union of the 26 States of Brazil, states and the Federal District (Brazil), Federal District. It is the largest country to have Portuguese language, Portuguese as an List of territorial entities where Portuguese is an official language, official language and the only one in the Americas; one of the most Multiculturalism, multicultural and ethnically diverse nations, due to over a century of mass Immigration to Brazil, immigration from around the world; and the most populous Catholic Church by country, Roman Catholic-majority country. Bounded by the Atlantic Ocean on the east, Brazil has a Coastline of Brazi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bolivia
, image_flag = Bandera de Bolivia (Estado).svg , flag_alt = Horizontal tricolor (red, yellow, and green from top to bottom) with the coat of arms of Bolivia in the center , flag_alt2 = 7 × 7 square patchwork with the (top left to bottom right) diagonals forming colored stripes (green, blue, purple, red, orange, yellow, white, green, blue, purple, red, orange, yellow, from top right to bottom left) , other_symbol = , other_symbol_type = Dual flag: , image_coat = Escudo de Bolivia.svg , national_anthem = " National Anthem of Bolivia" , image_map = BOL orthographic.svg , map_width = 220px , alt_map = , image_map2 = , alt_map2 = , map_caption = , capital = La Paz Sucre , largest_city = , official_languages = Spanish , languages_type = Co-official languages , languages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strain (biology)
In biology, a strain is a genetic variant, a subtype or a culture within a biological species. Strains are often seen as inherently artificial concepts, characterized by a specific intent for genetic isolation. This is most easily observed in microbiology where strains are derived from a single cell colony and are typically quarantined by the physical constraints of a Petri dish. Strains are also commonly referred to within virology, botany, and with rodents used in experimental studies. Microbiology and virology It has been said that "there is no universally accepted definition for the terms 'strain', ' variant', and 'isolate' in the virology community, and most virologists simply copy the usage of terms from others". A strain is a genetic variant or subtype of a microorganism (e.g., a virus, bacterium or fungus). For example, a "flu strain" is a certain biological form of the influenza or "flu" virus. These flu strains are characterized by their differing isoforms of su ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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