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Avon Longitudinal Study Of Parents And Children
The Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s and formerly the Avon Longitudinal Study of Pregnancy and Childhood, is a cohort study of children born in the former county of Avon, England during 1991 and 1992.http://www.bristol.ac.uk/alspac/ ALSPAC website, accessed 15 October 2014 It is used by researchers in health, education and other social science disciplines. The study is hosted at the University of Bristol and was initially led by Jean Golding, then George Davey Smith. Currently the Principal Investigator for the study is Prof Nic Timpson. The initial recruits were 15,247 pregnant women with estimated dates of delivery between April 1991 and December 1992. Since then the fathers, siblings and children of the participants have also begun to be studied and the study has launched Children of the Children of the 90s as a new generation is born. It is one of a family of similar studies that were set up at around the same time ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Czechoslovakia
, rue, Чеськословеньско, , yi, טשעכאסלאוואקיי, , common_name = Czechoslovakia , life_span = 1918–19391945–1992 , p1 = Austria-Hungary , image_p1 = , s1 = Czech Republic , flag_s1 = Flag of the Czech Republic.svg , s2 = Slovakia , flag_s2 = Flag of Slovakia.svg , image_flag = Flag of Czechoslovakia.svg , flag = Flag of Czechoslovakia , flag_type = Flag(1920–1992) , flag_border = Flag of Czechoslovakia , image_coat = Middle coat of arms of Czechoslovakia.svg , symbol_type = Middle coat of arms(1918–1938 and 1945–1961) , image_map = Czechoslovakia location map.svg , image_map_caption = Czechoslovakia during the interwar period and the Cold War , national_motto = , anthems = ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cirrhosis
Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is the impaired liver function caused by the formation of scar tissue known as fibrosis due to damage caused by liver disease. Damage causes tissue repair and subsequent formation of scar tissue, which over time can replace normal functioning tissue, leading to the impaired liver function of cirrhosis. The disease typically develops slowly over months or years. Early symptoms may include tiredness, weakness, loss of appetite, unexplained weight loss, nausea and vomiting, and discomfort in the right upper quadrant of the abdomen. As the disease worsens, symptoms may include itchiness, swelling in the lower legs, fluid build-up in the abdomen, jaundice, bruising easily, and the development of spider-like blood vessels in the skin. The fluid build-up in the abdomen may become spontaneously infected. More serious complications include hepatic encephalopathy, bleeding from dilated veins ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fibrosis
Fibrosis, also known as fibrotic scarring, is a pathological wound healing in which connective tissue replaces normal parenchymal tissue to the extent that it goes unchecked, leading to considerable tissue remodelling and the formation of permanent scar tissue. Repeated injuries, chronic inflammation and repair are susceptible to fibrosis where an accidental excessive accumulation of extracellular matrix components, such as the collagen is produced by fibroblasts, leading to the formation of a permanent fibrotic scar. In response to injury, this is called scarring, and if fibrosis arises from a single cell line, this is called a fibroma. Physiologically, fibrosis acts to deposit connective tissue, which can interfere with or totally inhibit the normal architecture and function of the underlying organ or tissue. Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing. Define ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fatty Liver Disease
Fatty liver disease (FLD), also known as hepatic steatosis, is a condition where excess fat builds up in the liver. Often there are no or few symptoms. Occasionally there may be tiredness or pain in the upper right side of the abdomen. Complications may include cirrhosis, liver cancer, and esophageal varices. There are two types of fatty liver disease: non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease. NAFLD is made up of simple fatty liver and non-alcoholic steatohepatitis (NASH). The primary risks include alcohol, type 2 diabetes, and obesity. Other risk factors include certain medications such as glucocorticoids, and hepatitis C. It is unclear why some people with NAFLD develop simple fatty liver and others develop NASH. Diagnosis is based on the medical history supported by blood tests, medical imaging, and occasionally liver biopsy. Treatment of NAFLD is generally by dietary changes and exercise to bring about weight loss. In those who are severely affe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steatosis
Steatosis, also called fatty change, is abnormal retention of fat (lipids) within a cell or organ. Steatosis most often affects the liver – the primary organ of lipid metabolism – where the condition is commonly referred to as fatty liver disease. Steatosis can also occur in other organs, including the kidneys, heart, and muscle. When the term is not further specified (as, for example, in 'cardiac steatosis'), it is assumed to refer to the liver. Risk factors associated with steatosis are varied, and may include diabetes mellitus, protein malnutrition, hypertension, cell toxins, obesity, anoxia, and sleep apnea. Steatosis reflects an impairment of the normal processes of synthesis and elimination of triglyceride fat. Excess lipid accumulates in vesicles that displace the cytoplasm. When the vesicles are large enough to distort the nucleus, the condition is known as macrovesicular steatosis; otherwise, the condition is known as microvesicular steatosis. While not particul ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transient Elastography
Elastography is any of a class of medical imaging modalities that map the elastic properties and stiffness of soft tissue.Sarvazyan A, Hall TJ, Urban MW, Fatemi M, Aglyamov SR, Garra BSOverview of elastography–an emerging branch of medical imaging Current Medical Imaging Reviews, 2011, 7(4):255-282. The main idea is that whether the tissue is hard or soft will give diagnostic information about the presence or status of disease. For example, cancerous tumours will often be harder than the surrounding tissue, and diseased livers are stiffer than healthy ones. The most prominent techniques use ultrasound or magnetic resonance imaging (MRI) to make both the stiffness map and an anatomical image for comparison. Historical background Palpation is the practice of feeling the stiffness of a person's or animal´s tissues with the health practitioner's hands. Manual palpation dates back at least to 1500 BC, with the Egyptian Ebers Papyrus and Edwin Smith Papyrus both giving instruct ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isle Of Man
) , anthem = "O Land of Our Birth" , image = Isle of Man by Sentinel-2.jpg , image_map = Europe-Isle_of_Man.svg , mapsize = , map_alt = Location of the Isle of Man in Europe , map_caption = Location of the Isle of Man (green) in Europe (dark grey) , subdivision_type = Sovereign state , subdivision_name = United Kingdom , established_title = Norse control , established_date = 9th century , established_title2 = Scottish control , established_date2 = 2 July 1266 , established_title3 = English control , established_date3 = 1399 , established_title4 = Revested into British Crown , established_date4 = 10 May 1765 , official_languages = , capital = Douglas , coordinates = , demonym = Manx; Manxman (plural, Manxmen); Manxwoman (plural, Manxwomen) , ethnic_groups = , ethnic_groups_year = 2021 , ethnic_groups_ref = Official census statistics provided by Statistics Isle of Man, Isle of Man Government: * * , religion = , religion_year = 2021 , relig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nic Timpson
NIC may refer to: Banking and insurance companies * National Insurance Corporation, Uganda * NIC Bank, a commercial bank in Kenya Politics, government and economics * National Ice Center, an agency that provides worldwide navigational ice analyses for the United States military and government * National Incubation Center, Ignite - National Technology Fund, Ministry of IT & Telecom, Government of Pakistan * Natal Indian Congress, a political party in South Africa formed by Mohandas Karamchand Gandhi * National Implementation Committee on FATA Reforms, a committee chaired by the Prime Minister of Pakistan regarding the Federally Administered Tribal Areas * National Indigenous Council, an advisory body to the Australian Government from late 2004 to early 2008 * National Informatics Centre, Government of India * National Infrastructure Commission, a UK government body advising on large-scale infrastructure projects * National Institute of Corrections, a division of the United St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Davey Smith
George Davey Smith (born 9 May 1959) is a British epidemiologist. He has been professor of clinical epidemiology at the University of Bristol since 1994, honorary professor of public health at the University of Glasgow since 1996, and visiting professor at the London School of Hygiene and Tropical Medicine since 1999. He was also the scientific director of the Avon Longitudinal Study of Parents and Children (until replaced in 2017 by Nic Timpson) and a former editor-in-chief of the ''International Journal of Epidemiology''. Education Davey Smith attended Stockton Heath Primary School and Lymm Grammar School in Warrington in North West England. He received a BA from Queen's College, Oxford in 1981, an MB BChir from Jesus College, Cambridge in 1984, an MSc from the London School of Hygiene and Tropical Medicine in 1988, an MD from Jesus College, Cambridge in 1991, and a DSc from Queen's College, Oxford in 2000. Honours and awards Davey Smith is an ISI highly cited resea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Principal Investigator
In many countries, the term principal investigator (PI) refers to the holder of an independent grant and the lead researcher for the grant project, usually in the sciences, such as a laboratory study or a clinical trial. The phrase is also often used as a synonym for "head of the laboratory" or "research group leader". While the expression is common in the sciences, it is used widely for the person or persons who make final decisions and supervise funding and expenditures on a given research project. A co-investigator (Co-I) assists the principal investigator in the management and leadership of the research project. There may be a number of co-investigators supporting a PI. Federal funding In the context of United States federal funding from agencies such as the National Institutes of Health (NIH) or the National Science Foundation (NSF), the PI is the person who takes direct responsibility for completion of a funded project, directing the research and reporting directly to the fun ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of GlaxoSmithKline) to fund research to improve human and animal health. The aim of the Trust is to "support science to solve the urgent health challenges facing everyone." It had a financial endowment of Pound sterling, £29.1 billion in 2020, making it the fourth List of wealthiest charitable foundations, wealthiest charitable foundation in the world. In 2012, the Wellcome Trust was described by the ''Financial Times'' as the United Kingdom's largest provider of non-governmental funding for scientific research, and one of the largest providers in the world. According to their annual report, the Wellcome Trust spent GBP Pound sterling, £1.1Bn on charitable activities across their 2019/2020 financial year. According to the OECD, the Wellcome ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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