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Arsonic Acids
Arsonic acids are a subset of organoarsenic compounds defined as oxyacids where a pentavalent arsenic atom is bonded to two hydroxyl groups, a third oxygen atom (this one with a double bond), and an organic substituent. The salts/conjugate bases of arsonic acids are called arsonates. Like all arsenic-containing compounds, arsonic acids are toxic and carcinogenic to humans. Arsonic acid refers to , the case where the substituent is a single hydrogen atom. The other arsonic acids can simply be viewed as hydrocarbyl derivatives of this base case. Arsenic acid results when the substituent is a hydroxyl group. Methylarsonic acid results when the substituent is a methyl group. Phenylarsonic acid results when the substituent is a phenyl group. Syntheses The Béchamp reaction is used to produce arsonic acids from activated aromatic substrates. The reaction is an electrophilic aromatic substitution, using arsenic acid as the electrophile. The reaction proceeds according to this idealiz ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arsonic Acid Group
Arsenic is a chemical element with the symbol As and atomic number 33. Arsenic occurs in many minerals, usually in combination with sulfur and metals, but also as a pure elemental crystal. Arsenic is a metalloid. It has various allotropes, but only the gray form, which has a metallic appearance, is important to industry. The primary use of arsenic is in alloys of lead (for example, in car batteries and ammunition). Arsenic is a common n-type dopant in semiconductor electronic devices. It is also a component of the III-V compound semiconductor gallium arsenide. Arsenic and its compounds, especially the trioxide, are used in the production of pesticides, treated wood products, herbicides, and insecticides. These applications are declining with the increasing recognition of the toxicity of arsenic and its compounds. A few species of bacteria are able to use arsenic compounds as respiratory metabolites. Trace quantities of arsenic are an essential dietary element in rats, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bechamp Reaction
In organic synthesis the Béchamp reaction is used for producing arsonic acids from activated aromatic substrates. The reaction is an electrophilic aromatic substitution, using arsenic acid as the electrophile. The reaction proceeds according to this idealized stoichiometry for the preparation of arsanilic acid: : Reaction scope The reaction was first reported in 1863 by Antoine Béchamp. It is very analogous to the sulfonation of arenes. The Béchamp reaction was employed in the Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...-winning work on organoarsenicals by Paul Erlich. In one commercial application, the Béchamp reaction is reaction is used to produce roxarsone, which exhibits an anticoccidial action and promotes growth in animals. Further reading * R ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fleming Laboratories
Fleming may refer to: Places Australia *Fleming, Northern Territory, a town and a locality Canada * Fleming, Saskatchewan * Fleming Island (Saskatchewan) Egypt * Fleming (neighborhood), a neighborhood in Alexandria Greenland * Fleming Fjord Italy * Fleming (Rome), a neighborhood United States * Fleming, Colorado *Fleming, Georgia * Fleming, Indiana * Fleming, Kansas * Fleming, Kentucky, a predecessor of Fleming-Neon, Kentucky, in Letcher County * Fleming County, Kentucky * Fleming, Missouri * Fleming, New York * Fleming, Ohio People * Fleming (surname) * Flemings, demonym for the Flemish people of Flanders, Belgium * Clan Fleming, a Scottish clan Other uses * Fleming (crater), a lunar crater * Fleming Building, a building in Des Moines, Iowa, United States * Fleming College, a college in Peterborough, Ontario, Canada * Fleming Companies, Inc, an American food supply company * , more than one United States Navy ship * '' Fleming: The Man Who Would Be Bond'', 2014 TV mini-se ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zoetis
Zoetis Inc. (/zō-EH-tis/) is an American drug company, the world's largest producer of medicine and vaccinations for pets and livestock. The company was a subsidiary of Pfizer, the world's largest drug maker, but with Pfizer's spinoff of its 83% interest in the firm it is now a completely independent company. The company directly markets its products in approximately 45 countries, and sells them in more than 100 countries. Operations outside the United States accounted for 50% of the total revenue. Contemporaneous with the spinoff in June 2013 S&P Dow Jones Indices announced that Zoetis would replace First Horizon National Corporation in the S&P 500 stock market index. History 1950s to 2000s In the 1950s, Pfizer began research on several drugs, including oxytetracycline, which was found to be effective in livestock. In 1952, the Pfizer Agriculture Division opened a 732-acre research and development facility in Terre Haute, Indiana, called Vigo. By 1988 the division was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Environmental Health Perspectives
''Environmental Health Perspectives'' (''EHP'') is a peer-reviewed Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work (peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer review ... open access journal published monthly with support from the U.S. National Institute of Environmental Health Sciences (NIEHS). The primary purposes of ''EHP'' are to communicate recent scientific findings and trends in the environmental health sciences; to improve the environmental health knowledge base among researchers, administrators, and policy makers; and to inform the public about important topics in environmental health. Journal homepag References {{reflist Environmental social science journals Publications established in 1972 Monthly journals English-language journals Open access journals Environmental health journals Academic journals published by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poultry
Poultry () are domesticated birds kept by humans for their eggs, their meat or their feathers. These birds are most typically members of the superorder Galloanserae (fowl), especially the order Galliformes (which includes chickens, quails, and turkeys). The term also includes birds that are killed for their meat, such as the young of pigeons (known as squabs) but does not include similar wild birds hunted for sport or food and known as game. The word "poultry" comes from the French/Norman word ''poule'', itself derived from the Latin word ''pullus'', which means "small animal". Recent genomic study involving the four extant Junglefowl species reveals that the domestication of chicken, the most populous poultry species, occurred around 8,000 years ago in Southeast Asia - although this was previously believed to have occurred later - around 5,400 years ago - in Southeast Asia. The process may have originally occurred as a result of people hatching and rearing young birds fro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Histomoniasis
Histomoniasis is a commercially significant disease of poultry, particularly of chickens and turkeys, due to parasitic infection of a protozoan, ''Histomonas meleagridis''. The protozoan is transmitted to the bird by the nematode parasite ''Heterakis gallinarum''. ''H. meleagridis'' resides within the eggs of ''H. gallinarum'', so birds ingest the parasites along with contaminated soil or food. Earthworms can also act as a paratenic host. ''Histomonas meleagridis'' specifically infects the cecum and liver. Symptoms of the infection include lethargy, reduced appetite, poor growth, increased thirst, sulphur-yellow diarrhoea and dry, ruffled feathers. The head may become cyanotic (bluish in colour), hence the common name of the disease, blackhead disease; thus the name 'blackhead' is in all possibility a misnomer for discoloration. The disease carries a high mortality rate, and is particularly highly fatal in poultry, and less in other birds. Currently, no prescription drug is approved ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roxarsone
Roxarsone is an organoarsenic compound that has been used in poultry production as a feed additive to increase weight gain and improve feed efficiency, and as a coccidiostat. As of June 2011, it was approved for chicken feed in the United States, Canada, Australia, and 12 other countries. The drug was also approved in the United States and elsewhere for use in pigs. Its use in the United States was voluntarily ended by the manufacturers in June 2011 and has been illegal since 2013. Its use was immediately suspended in Malaysia. It was banned in Canada in August 2011. In Australia, its use in chicken feed was discontinued in 2012. Roxarsone has been banned in the European Union since 1999. Production and applications Roxarsone is a derivative of phenylarsonic acid (C6H5As(O)(OH)2). It was first reported in a 1923 British patent that described the nitration and diazotization of arsanilic acid. When blended with calcite powder, it is used in poultry feed premixes in some parts of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitarsone
Nitarsone is an organoarsenic compound that is used in poultry production as a feed additive to increase weight gain, improve feed efficiency, and prevent histomoniasis (blackhead disease). It is marketed as Histostat by Zoetis. Nitarsone once was one of four arsenical food-animal drugs—along with roxarsone, arsanilic acid, and carbarsone—approved by the U.S. Food and Drug Administration for use in feeding poultry. However, following the suspension of sales of roxarsone in the United States in 2011, nitarsone was thought to be the only arsenical animal drug actually marketed in the U.S. In September 2013, the FDA announced that Zoetis and Fleming Laboratories agreed to voluntarily withdraw from using roxarsone, arsanilic acid, and carbarsone Carbarsone is an organoarsenic compound used as an antiprotozoal drug for treatment of amebiasis and other infections. It was available for amebiasis in the United States as late as 1991. Thereafter, it remained available as a t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbarsone
Carbarsone is an organoarsenic compound used as an antiprotozoal drug for treatment of amebiasis and other infections. It was available for amebiasis in the United States as late as 1991. Thereafter, it remained available as a turkey feed additive for increasing weight gain and controlling histomoniasis (blackhead disease). Carbarsone is one of four arsenical animal drugs approved by the U.S. Food and Drug Administration for use in poultry and/or swine, along with nitarsone, arsanilic acid, and roxarsone. In September 2013, the FDA announced that Zoetis and Fleming Laboratories would voluntarily withdraw current roxarsone, arsanilic acid, and carbarsone approvals, leaving only nitarsone Nitarsone is an organoarsenic compound that is used in poultry production as a feed additive to increase weight gain, improve feed efficiency, and prevent histomoniasis (blackhead disease). It is marketed as Histostat by Zoetis. Nitarsone once ... approvals in place. In 2015 FDA withdrew t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arsanilic Acid
Arsanilic acid, also known as aminophenyl arsenic acid or aminophenyl arsonic acid, is an organoarsenic compound, an amino derivative of phenylarsonic acid whose amine group is in the 4-position. A crystalline powder introduced medically in the late 19th century as Atoxyl, its sodium salt was used by injection in the early 20th century as the first organic arsenical drug, but it was soon found prohibitively toxic for human use. Arsanilic acid saw long use as a veterinary feed additive promoting growth and to prevent or treat dysentery in poultry and swine. In 2013, its approval by US government as an animal drug was voluntarily withdrawn by its sponsors. Still sometimes used in laboratories, arsanilic acid's legacy is principally through its influence on Paul Ehrlich in launching the antimicrobial chemotherapy approach to treating infectious diseases of humans. Chemistry Synthesis was first reported in 1863 by Antoine Béchamp and became the basis of the Bechamp reaction. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nitarsone
Nitarsone is an organoarsenic compound that is used in poultry production as a feed additive to increase weight gain, improve feed efficiency, and prevent histomoniasis (blackhead disease). It is marketed as Histostat by Zoetis. Nitarsone once was one of four arsenical food-animal drugs—along with roxarsone, arsanilic acid, and carbarsone—approved by the U.S. Food and Drug Administration for use in feeding poultry. However, following the suspension of sales of roxarsone in the United States in 2011, nitarsone was thought to be the only arsenical animal drug actually marketed in the U.S. In September 2013, the FDA announced that Zoetis and Fleming Laboratories agreed to voluntarily withdraw from using roxarsone, arsanilic acid, and carbarsone Carbarsone is an organoarsenic compound used as an antiprotozoal drug for treatment of amebiasis and other infections. It was available for amebiasis in the United States as late as 1991. Thereafter, it remained available as a t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
