Carbarsone is an

organoarsenic compound Organoarsenic chemistry is the chemistry of compounds containing a chemical bond between arsenic and carbon. A few organoarsenic compounds, also called "organoarsenicals," are produced industrially with uses as insecticides, herbicides, and fungic ...

used as an antiprotozoal drug for treatment of

amebiasis Amoebiasis, or amoebic dysentery, is an infection of the intestines caused by a parasitic amoeba ''Entamoeba histolytica''. Amoebiasis can be present with no, mild, or severe symptoms. Symptoms may include lethargy, loss of weight, colonic ulc ...

and other infections. It was available for amebiasis in the United States as late as 1991. Thereafter, it remained available as a

turkey Turkey ( tr, Türkiye ), officially the Republic of Türkiye ( tr, Türkiye Cumhuriyeti, links=no ), is a list of transcontinental countries, transcontinental country located mainly on the Anatolia, Anatolian Peninsula in Western Asia, with ...

feed additive for increasing weight gain and controlling histomoniasis (blackhead disease). Carbarsone is one of four

arsenical Arsenicals are chemical compounds that contain arsenic. In a military context, the term arsenical refer to toxic arsenic compounds that are used as chemical warfare agents. This include blister agents, blood agents and vomiting agents. Examples Bli ...

animal drugs approved by the

U.S. Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

for use in poultry and/or swine, along with

nitarsone Nitarsone is an organoarsenic compound that is used in poultry production as a feed additive to increase weight gain, improve feed efficiency, and prevent histomoniasis (blackhead disease). It is marketed as Histostat by Zoetis. Nitarsone once ...

arsanilic acid Arsanilic acid, also known as aminophenyl arsenic acid or aminophenyl arsonic acid, is an organoarsenic compound, an amino derivative of phenylarsonic acid whose amine group is in the 4-position. A crystalline powder introduced medically in the l ...

, and roxarsone. In September 2013, the FDA announced that

Zoetis Zoetis Inc. (/zō-EH-tis/) is an American drug company, the world's largest producer of medicine and vaccinations for pets and livestock. The company was a subsidiary of Pfizer, the world's largest drug maker, but with Pfizer's spinoff of its ...

and

Fleming Laboratories Fleming may refer to: Places Australia *Fleming, Northern Territory, a town and a locality Canada * Fleming, Saskatchewan * Fleming Island (Saskatchewan) Egypt * Fleming (neighborhood), a neighborhood in Alexandria Greenland * Fleming Fjord ...

would voluntarily withdraw current roxarsone,

, and carbarsone approvals, leaving only

approvals in place. In 2015 FDA withdrew the approval of using nitarsone in animal feeds. The ban came into effect at the end of 2015.

References

Antiprotozoal agents Arsonic acids Ureas Anilines {{antiinfective-drug-stub