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Anton Köllisch
Anton Köllisch (16 March 1888 – September 1916) was a German chemist who, whilst working at Darmstadt for pharmaceutical giant Merck, first described the synthesis of the chemical MDMA. Life and work In 1911, Köllisch published his doctoral dissertation on the topic of indole synthesis from hydrazones under Otto Diels at the University of Berlin. While at Merck, Dr Köllisch was involved in investigating syntheses for methylhydrastinine and hydrastinine. A procedural patent was filed on Christmas Eve 1912 relating to these syntheses, which mentioned MDMA without name as a chemical intermediate. He was killed in the First World War. References Bibliography * Germany, Kaiserliches Patentamt, Patentschrift Nr 274350, http://mdma.net/merck/mdma-patent1.html * * Adam, David. Truth about ecstasy's unlikely trip from lab to dance floor Pharmaceutical company unravels drug's chequered past'', Guardian Unlimited TheGuardian.com, formerly known as Guardian.co.uk and ''Gua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Darmstadt
Darmstadt () is a city in the States of Germany, state of Hesse in Germany, located in the southern part of the Frankfurt Rhine Main Area, Rhine-Main-Area (Frankfurt Metropolitan Region). Darmstadt has around 160,000 inhabitants, making it the fourth largest city in the state of Hesse after Frankfurt am Main, Wiesbaden, and Kassel. Darmstadt holds the official title "City of Science" (german: link=no, Wissenschaftsstadt) as it is a major centre of scientific institutions, universities, and high-technology companies. The European Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) and the European Space Operations Centre (ESOC) are located in Darmstadt, as well as Gesellschaft für Schwerionenforschung, GSI Centre for Heavy Ion Research, where several chemical elements such as bohrium (1981), meitnerium (1982), hassium (1984), darmstadtium (1994), roentgenium (1994), and copernicium (1996) were discovered. The existence of the following elements were also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Merck KGaA
The Merck Group, branded and commonly known as Merck, is a German multinational science and technology company headquartered in Darmstadt, with about 60,000 employees and present in 66 countries. The group includes around 250 companies; the main company is Merck KGaA in Germany. The company is divided into three business lines: Healthcare, Life Sciences and Electronics. Merck was founded in 1668 and is the world's oldest operating chemical and pharmaceutical company, as well as one of the largest pharmaceutical companies in the world. Merck operates in Europe, Africa, Asia, Oceania and the Americas. It has major research and development centres in Darmstadt, Boston, Tokyo and Beijing, as well as other Research and Development units in Taiwan, France, Israel, South Korea, India and in the UK. Merck pioneered the commercial manufacture of morphine in the 19th century and for a time held a virtual monopoly on cocaine. Merck was privately owned until going public on the Frankfurt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in Tablet (pharmacy), tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for Recreational drug use, recreational purposes. The desired effects include altered Sense, sensations, increased energy, empathy, and pleasure. When taken by mouth, effects begin in 30 to 45 minutes and last 3 to 6 hours. MDMA was first developed in 1912 by Merck Group, Merck. It was used to enhance psychotherapy beginning in the 1970s and became popular as a street drug in the 1980s. MDMA is commonly associated with dance party, dance parties, raves, and electronic dance music. It may be Cutting agent, mixed with other substances such as ephedrine, amphetamine, and methamphetamine. In 2016, about 21 million people between the ages of 15 and 64 used ecstasy (0.3% of the world population). This was broadly similar to the percentage of people who use cocaine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Indole
Indole is an aromatic heterocyclic organic compound with the formula C8 H7 N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria. As an intercellular signal molecule, indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence. The amino acid tryptophan is an indole derivative and the precursor of the neurotransmitter serotonin. General properties and occurrence Indole is a solid at room temperature. It occurs naturally in human feces and has an intense fecal odor. At very low concentrations, however, it has a flowery smell, and is a constituent of many perfumes. It also occurs in coal tar. The corresponding substituent is called indolyl. Indole undergoes electrophilic substitution, mainly at position 3 (see diagra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrazone
Hydrazones are a class of organic compounds with the structure . They are related to ketones and aldehydes by the replacement of the oxygen =O with the = functional group. They are formed usually by the action of hydrazine on ketones or aldehydes. Synthesis Hydrazine, organohydrazines, and 1,1-diorganohydrazines react with aldehydes and ketones to give hydrazones. : Phenylhydrazine reacts with reducing sugars to form hydrazones known as osazones, which was developed by German chemist Emil Fischer as a test to differentiate monosaccharides. Uses Hydrazones are the basis for various analyses of ketones and aldehydes. For example, dinitrophenylhydrazine coated onto a silica sorbent is the basis of an adsorption cartridge. The hydrazones are then eluted and analyzed by HPLC using a UV detector. The compound carbonyl cyanide-''p''-trifluoromethoxyphenylhydrazone (abbreviated as FCCP) is used to uncouple ATP synthesis and reduction of oxygen in oxidative phosphorylation in molecu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Otto Diels
Otto Paul Hermann Diels (; 23 January 1876 – 7 March 1954) was a German chemist. His most notable work was done with Kurt Alder on the Diels–Alder reaction, a method for diene synthesis. The pair was awarded the Nobel Prize in Chemistry in 1950 for their work. Their method of synthesizing cyclic organic compounds proved valuable for the manufacture of synthetic rubber and plastic. He completed his education at the University of Berlin, where he later worked. Diels was employed at the University of Kiel when he completed his Nobel Prize–winning work, and remained there until he retired in 1945. Diels was married, with five children. He died in 1954. Early life Diels was born on 23 January 1876 in Hamburg, Germany, and moved with his family to Berlin when he was two years old. He studied in Berlin at Joachimsthalsches Gymnasium before attending the University of Berlin starting in 1895. While at university, Diels studied chemistry under Emil Fischer, eventually g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Berlin
Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative of Wilhelm von Humboldt, Johann Gottlieb Fichte and Friedrich Ernst Daniel Schleiermacher as the University of Berlin () in 1809, and opened in 1810, making it the oldest of Berlin's four universities. From 1828 until its closure in 1945, it was named Friedrich Wilhelm University (german: Friedrich-Wilhelms-Universität). During the Cold War, the university found itself in East Berlin and was ''de facto'' split in two when the Free University of Berlin opened in West Berlin. The university received its current name in honour of Alexander and Wilhelm von Humboldt in 1949. The university is divided into nine faculties including its medical school shared with the Freie Universität Berlin. The university has a student enrollment of around ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anton Köllisch
Anton Köllisch (16 March 1888 – September 1916) was a German chemist who, whilst working at Darmstadt for pharmaceutical giant Merck, first described the synthesis of the chemical MDMA. Life and work In 1911, Köllisch published his doctoral dissertation on the topic of indole synthesis from hydrazones under Otto Diels at the University of Berlin. While at Merck, Dr Köllisch was involved in investigating syntheses for methylhydrastinine and hydrastinine. A procedural patent was filed on Christmas Eve 1912 relating to these syntheses, which mentioned MDMA without name as a chemical intermediate. He was killed in the First World War. References Bibliography * Germany, Kaiserliches Patentamt, Patentschrift Nr 274350, http://mdma.net/merck/mdma-patent1.html * * Adam, David. Truth about ecstasy's unlikely trip from lab to dance floor Pharmaceutical company unravels drug's chequered past'', Guardian Unlimited TheGuardian.com, formerly known as Guardian.co.uk and ''Gua ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrastinine
Hydrastinine is a semisynthetic alkaloid from the hydrolysis of the alkaloid hydrastine, which was found naturally in small quantities in ''Hydrastis canadensis'' L. (Ranunculaceae). Hydrastinine was produced by oxidative splitting of hydrastine hydrochloride with nitric acid in good yield. The drug was patented by Bayer as a haemostatic drug during the 1910s. The first known synthesis of methylenedioxymethamphetamine (MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in Tablet (pharmacy), tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for Recreational dru ...) was actually an intermediate in the synthesis of the methylated analogue of hydrastinine, methylhydrastinine. It was only reviewed for its activity many years after its original synthesis. Hydrastinine has also been found as an impurity or side product in MDMA synthesis performed by low pressure amination of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Christmas Eve
Christmas Eve is the evening or entire day before Christmas Day, the festival commemorating the birth of Jesus. Christmas Day is observed around the world, and Christmas Eve is widely observed as a full or partial holiday in anticipation of Christmas Day. Together, both days are considered one of the most culturally significant celebrations in Christendom and Western society. Christmas celebrations in the denominations of Western Christianity have long begun on Christmas Eve, due in part to the Christian liturgical day starting at sunset, a practice inherited from Jewish tradition and based on the story of Creation in the Book of Genesis: "And there was evening, and there was morning – the first day." Many churches still ring their church bells and hold prayers in the evening; for example, the Nordic Lutheran churches. Since tradition holds that Jesus was born at night (based in Luke 2:6-8), Midnight Mass is celebrated on Christmas Eve, traditionally at midnight, in c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
First World War
World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fighting occurring throughout Europe, the Middle East, Africa, the Pacific, and parts of Asia. An estimated 9 million soldiers were killed in combat, plus another 23 million wounded, while 5 million civilians died as a result of military action, hunger, and disease. Millions more died in genocides within the Ottoman Empire and in the 1918 influenza pandemic, which was exacerbated by the movement of combatants during the war. Prior to 1914, the European great powers were divided between the Triple Entente (comprising France, Russia, and Britain) and the Triple Alliance (containing Germany, Austria-Hungary, and Italy). Tensions in the Balkans came to a head on 28 June 1914, following the assassination of Archduke Franz Ferdina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guardian Unlimited
TheGuardian.com, formerly known as Guardian.co.uk and ''Guardian Unlimited'', is a British news and media website owned by the Guardian Media Group. It contains nearly all of the content of the newspapers ''The Guardian'' and ''The Observer'', as well as a substantial body of web-only work produced by its own staff, including a rolling news service. As of November 2014, it was the second most popular online newspaper in the UK with over 17 million readers per month; with over 21 million monthly readers, Mail Online was the most popular. The site is made up of a core news site, with niche sections and subsections covering subjects including sport, business, environment, technology, arts and media, and lifestyle. TheGuardian.com is notable for its engagement with readers, including long-running talkboards and, more recently, a network of weblogs. Its seven blogs were joined on 14 March 2006, by a new comment section, "Comment is free", which has since merged into its Opinion secti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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