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Andrew Huxley (law Scholar)
Sir Andrew Fielding Huxley (22 November 191730 May 2012) was an English physiologist and biophysicist. He was born into the prominent Huxley family. After leaving Westminster School in central London, he went to Trinity College, Cambridge, on a scholarship, after which he joined Alan Hodgkin to study nerve impulses. Their eventual discovery of the basis for propagation of nerve impulses (called an action potential) earned them the Nobel Prize in Physiology or Medicine in 1963. They made their discovery from the giant axon of the Atlantic squid. Soon after the outbreak of the Second World War, Huxley was recruited by the British Anti-Aircraft Command and later transferred to the Admiralty. After the war he resumed research at the University of Cambridge, where he developed interference microscopy that would be suitable for studying muscle fibres. In 1952, he was joined by a German physiologist Rolf Niedergerke. Together they discovered in 1954 the mechanism of mus ...
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Knight Bachelor
The title of Knight Bachelor is the basic rank granted to a man who has been knighted by the monarch but not inducted as a member of one of the organised orders of chivalry; it is a part of the British honours system. Knights Bachelor are the most ancient sort of British knight (the rank existed during the 13th-century reign of King Henry III), but Knights Bachelor rank below knights of chivalric orders. A man who is knighted is formally addressed as "Sir irst Name urname or "Sir irst Name and his wife as "Lady urname. Criteria Knighthood is usually conferred for public service; amongst its recipients are all male judges of His Majesty's High Court of Justice in England. It is possible to be a Knight Bachelor and a junior member of an order of chivalry without being a knight of that order; this situation has become rather common, especially among those recognized for achievements in entertainment. For instance, Sir Michael Gambon, Sir Derek Jacobi, Sir Anthony Hopkins, Sir ...
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Leonard Huxley (writer)
Leonard Huxley (11 December 1860 – 2 May 1933) was an English schoolteacher, writer and editor. Biography Family Huxley's father was the zoologist Thomas Henry Huxley, commonly referred to as 'Darwin's bulldog'. He was educated at University College School, London, the University of St Andrews, and Balliol College, Oxford. He first married Julia Arnold who founded a school. She was the daughter of the academic Tom Arnold. She was a sister of the novelist Mrs Humphry Ward, niece of the poet Matthew Arnold, and granddaughter of Thomas Arnold, the headmaster of Rugby School (immortalised as a character in ''Tom Brown's Schooldays''). Their four children included the biologist Julian Huxley (1887–1975) and the writer Aldous Huxley (1894–1963). Their middle son, Noel Trevenen (born in 1889), committed suicide in 1914. Their daughter, Margaret Arnold Huxley, was born in 1899. Julia Arnold died of cancer in 1908. After the death of his first wife, Leonard married Rosalind ...
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Rolf Niedergerke
Rolf Nidergerke (30 April 1921 – 27 December 2011) was a German physiologist and physician, and one of the discoverers of the sliding filament theory of muscle contraction. He and Andrew Huxley, complimenting the independent works of Hugh Huxley and Jean Hanson, revealed that muscle contraction is due to shortening of the muscle fibres. He studied medicine throughout the Second World War, and obtained his MD degree as the war ended in 1945. After a brief practise in his hometown, he chose a research career. He became associated with Huxley, whom he joined at Cambridge University. Together they published a landmark paper in ''Nature'' in 1954, which became the foundation of muscle mechanics. Early life and education Rolf Niedergerke was born and educated in Mülheim an der Ruhr. The turmoil of the Second World War almost interrupted his medical course when he was at Freiburg University. As a student of medicine he was exempted from conscription to serve in the German Army. How ...
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Interference Microscopy
Interference microscopy involving measurements of differences in the path between two beams of light that have been split. Types include: * Classical interference microscopy * Differential interference contrast microscopy * Fluorescence interference contrast microscopy * Interference reflection microscopy See also * Phase contrast microscopy __NOTOC__ Phase-contrast microscopy (PCM) is an optical microscopy technique that converts phase shifts in light passing through a transparent specimen to brightness changes in the image. Phase shifts themselves are invisible, but become visible ... References {{science-stub Microscopy ...
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World War II
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies and the Axis powers. World War II was a total war that directly involved more than 100 million personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the only two nuclear weapons ever used in war. World War II was by far the deadliest conflict in human history; it resulted in 70 to 85 million fatalities, mostly among civilians. Tens of millions died due to genocides (including the Holocaust), starvation, ma ...
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Longfin Inshore Squid
The longfin inshore squid (''Doryteuthis pealeii'') is a species of squid of the family Loliginidae. Description This species of squid is often seen with a reddish hue, but like many types of squid can manipulate its color, varying from a deep red to a soft pink. The dorsal mantle length of some males can reach up to 50 cm, although most squid commercially harvested are smaller than 30 cm long. This species exhibits sexual dimorphism, with most males growing faster and reaching larger sizes than females. Distribution The longfin inshore squid is found in the North Atlantic, schooling in continental shelf and slope waters from Newfoundland to the Gulf of Venezuela. It is commercially exploited, especially in the range from the Southern Georges Bank to Cape Hatteras. The population makes seasonal migrations that appear to be related to bottom water temperatures; they move offshore during late autumn to overwinter along the edge of the continental shelf and retur ...
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Squid Giant Axon
The squid giant axon is the very large (up to 1.5 mm in diameter; typically around 0.5 mm) axon that controls part of the water jet propulsion system in squid. It was first described by L. W. Williams in 1909, but this discovery was forgotten until English zoologist and neurophysiologist J. Z. Young demonstrated the axon's function in the 1930s while working in the Stazione Zoologica in Naples, the Marine Biological Association in Plymouth and the Marine Biological Laboratory in Woods Hole. Squids use this system primarily for making brief but very fast movements through the water. On the underside of the squid's body, between the head and the mantle, is a siphon through which water can be rapidly expelled by the fast contractions of the body wall muscles of the animal. This contraction is initiated by action potentials in the giant axon. Action potentials travel faster in a larger axon than a smaller one, and squid have evolved the giant axon to improve the speed ...
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Action Potential
An action potential occurs when the membrane potential of a specific cell location rapidly rises and falls. This depolarization then causes adjacent locations to similarly depolarize. Action potentials occur in several types of animal cells, called excitable cells, which include neurons, muscle cells, and in some plant cells. Certain endocrine cells such as pancreatic beta cells, and certain cells of the anterior pituitary gland are also excitable cells. In neurons, action potentials play a central role in cell-cell communication by providing for—or with regard to saltatory conduction, assisting—the propagation of signals along the neuron's axon toward synaptic boutons situated at the ends of an axon; these signals can then connect with other neurons at synapses, or to motor cells or glands. In other types of cells, their main function is to activate intracellular processes. In muscle cells, for example, an action potential is the first step in the chain of events l ...
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Alan Hodgkin
Sir Alan Lloyd Hodgkin (5 February 1914 – 20 December 1998) was an English physiologist and biophysicist who shared the 1963 Nobel Prize in Physiology or Medicine with Andrew Huxley and John Eccles. Early life and education Hodgkin was born in Banbury, Oxfordshire, on 5 February 1914. He was the oldest of three sons of Quakers George Hodgkin and Mary Wilson Hodgkin. His father was the son of Thomas Hodgkin and had read for the Natural Science Tripos at Cambridge where he had befriended electrophysiologist Keith Lucas. Because of poor eyesight he was unable to study medicine and eventually ended up working for a bank in Banbury. As members of the Society of Friends, George and Mary opposed the Military Service Act of 1916 and had to endure a great deal of abuse from their local community, including an attempt to throw George in one of the town canals. In 1916 George Hodgkin travelled to Armenia as part of an investigation of distress. Moved by the misery and suffering of ...
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Trinity College, Cambridge
Trinity College is a constituent college of the University of Cambridge. Founded in 1546 by Henry VIII, King Henry VIII, Trinity is one of the largest Cambridge colleges, with the largest financial endowment of any college at either Cambridge or University of Oxford, Oxford. Trinity has some of the most distinctive architecture in Cambridge with its Trinity Great Court, Great Court said to be the largest enclosed courtyard in Europe. Academically, Trinity performs exceptionally as measured by the Tompkins Table (the annual unofficial league table of Cambridge colleges), coming top from 2011 to 2017. Trinity was the top-performing college for the 2020-21 undergraduate exams, obtaining the highest percentage of good honours. Members of Trinity have been awarded 34 Nobel Prizes out of the 121 received by members of Cambridge University (the highest of any college at either Oxford or Cambridge). Members of the college have received four Fields Medals, one Turing Award and one Abel ...
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Westminster School
(God Gives the Increase) , established = Earliest records date from the 14th century, refounded in 1560 , type = Public school Independent day and boarding school , religion = Church of England , head_label = Head Master , head = Gary Savage , chair_label = Chairman of Governors , chair = John Hall, Dean of Westminster , founder = Henry VIII (1541) Elizabeth I (1560 – refoundation) , address = Little Dean's Yard , city = London, SW1P 3PF , country = England , local_authority = City of Westminster , urn = 101162 , ofsted = , dfeno = 213/6047 , staff = 105 , enrolment = 747 , gender = BoysCoeducational (Sixth Form) , lower_age = 13 (boys), 16 (girls) , upper_age = 18 , houses = Busby's College Ashburnham Dryden's Grant's Hakluyt's Liddell's Milne's Purcell's Rigaud's Wren's , colours = Pink , public ...
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Society For Neuroscience
The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, DC, for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well known for its annual meeting, consistently one of the largest scientific conferences in the world. History SfN was founded in 1969 by Ralph W. Gerard and, at nearly 37,000 members, has grown to be the largest neuroscience society in the world. The stated mission of the society is to: #Advance the understanding of the brain and the nervous system. #Provide professional development activities, information, and educational resources. #Promote public information and general education about science and neuroscience. #Inform legislators and other policy makers about the implications of research for public policy, societal benefit, and continued scientific progress. Annual meeting The Society holds an annual meeting that is attended by scien ...
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