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African Tick-bite Fever
African tick bite fever (ATBF) is a bacterial infection spread by the bite of a tick. Symptoms may include fever, headache, muscle pain, and a rash. At the site of the bite there is typically a red skin sore with a dark center. The onset of symptoms usually occurs 4–10 days after the bite. Complications are rare but may include joint inflammation. Some people do not develop symptoms. Tick bite fever is caused by the bacterium ''Rickettsia africae''. The bacterium is spread by ticks of the ''Amblyomma'' type. These generally live in tall grass or bush rather than in cities. The diagnosis is typically based on symptoms. It can be confirmed by culture, PCR, or immunofluorescence. There is no vaccine. Prevention is by avoiding tick bites by covering the skin, using DEET, or using permethrin treated clothing. Evidence regarding treatment, however, is limited. The antibiotic doxycycline appears useful. Chloramphenicol or azithromycin may also be used. The disease will also tend to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rickettsia Africae
''Rickettsia africae'' is a species of ''Rickettsia ''Rickettsia'' is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci (0.1 μm in diameter), bacilli (1–4 μm long), or threads (up to about 10 μm long). The term "ricke ...''. It can cause African tick-bite fever. References Rickettsiaceae {{Alphaproteobacteria-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doxycycline
Doxycycline is a broad-spectrum tetracycline class antibiotic used in the treatment of infections caused by bacteria and certain parasites. It is used to treat bacterial pneumonia, acne, chlamydia infections, Lyme disease, cholera, typhus, and syphilis. It is also used to prevent malaria in combination with quinine. Doxycycline may be taken by mouth or by injection into a vein. Common side effects include diarrhea, nausea, vomiting, abdominal pain, and an increased risk of sunburn. Use during pregnancy is not recommended. Like other agents of the tetracycline class, it either slows or kills bacteria by inhibiting protein production. It kills malaria by targeting a plastid organelle, the apicoplast. Doxycycline was patented in 1957 and came into commercial use in 1967. It is on the World Health Organization's List of Essential Medicines. Doxycycline is available as a generic medicine. In 2020, it was the 79th most commonly prescribed medication in the United States, with m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amblyomma Hebraeum, Steenbokpan, A
''Amblyomma'' is a genus of hard ticks. Some are disease vectors, for example the Rocky Mountain spotted fever in Brazil or ehrlichiosis in the United States. This genus is the third largest in the family Ixodidae, with its species primarily occupying the torrid zones of all the continents. The centre of species diversity is on the American continent, where half of all the species occur. On this continent, ''Amblyomma'' species reach far beyond the torrid zone, up to the 40th parallel in the Northern Hemisphere, to the 50th parallel in the Southern Hemisphere, and even reaches the alpine zone of the Andes. They also occur in Eurasia, Africa and Australia. G. V. Kolonin, Fauna of Ixodid Ticks of the World (Acari, Ixodidae), Moscow 2009 Species * '' A ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rickettsia
''Rickettsia'' is a genus of nonmotile, gram-negative, nonspore-forming, highly pleomorphic bacteria that may occur in the forms of cocci (0.1 μm in diameter), bacilli (1–4 μm long), or threads (up to about 10 μm long). The term "rickettsia" has nothing to do with rickets (which is a deficiency disease resulting from lack of vitamin D); the bacterial genus ''Rickettsia'' instead was named after Howard Taylor Ricketts, in honor of his pioneering work on tick-borne spotted fever. Properly, ''Rickettsia'' is the name of a single genus, but the informal term "rickettsia", plural "rickettsias", usually not capitalised, commonly applies to any members of the order Rickettsiales. Being obligate intracellular bacteria, rickettsias depend on entry, growth, and replication within the cytoplasm of living eukaryotic host cells (typically endothelial cells). Accordingly, ''Rickettsia'' species cannot grow in artificial nutrient culture; they must be grown either in tissue or embryo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pleomorphism (microbiology)
In microbiology, pleomorphism (from Ancient Greek , ''pléō'', "more", and , ''morphḗ'', form), also pleiomorphism, is the ability of some microorganisms to alter their morphology, biological functions or reproductive modes in response to environmental conditions. Pleomorphism has been observed in some members of the Deinococcaceae family of bacteria. The modern definition of pleomorphism in the context of bacteriology is based on ''variation'' of morphology or functional methods of the individual cell, rather than a heritable ''change'' of these characters as previously believed. Bacteria In the first decades of the 20th century, the term "pleomorphism" was used to refer to the idea that bacteria change morphology, biological systems, or reproductive methods dramatically according to environmental cues. This claim was controversial among microbiologists of the time, and split them into two schools: the monomorphists, who opposed the claim, and the pleomorphists such as Antoine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reactive Arthritis
Reactive arthritis, also known as Reiter's syndrome, is a form of inflammatory arthritis that develops in response to an infection in another part of the body (cross-reactivity). Coming into contact with bacteria and developing an infection can trigger the disease. By the time the patient presents with symptoms, often the "trigger" infection has been cured or is in remission in chronic cases, thus making determination of the initial cause difficult. The arthritis often is coupled with other characteristic symptoms; this has been called Reiter's syndrome, Reiter's disease or Reiter's arthritis. The term "reactive arthritis" is increasingly used as a substitute for this designation because of Hans Reiter's war crimes with the Nazi Party. The manifestations of reactive arthritis include the following triad of symptoms: an inflammatory arthritis of large joints, inflammation of the eyes in the form of conjunctivitis or uveitis, and urethritis in men or cervicitis in women. Arthrit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maculopapular Rash
A maculopapular rash is a type of rash characterized by a flat, red area on the skin that is covered with small confluent bumps. It may only appear red in lighter-skinned people. The term "maculopapular" is a compound: ''macules'' are small, flat discolored spots on the surface of the skin; and ''papules'' are small, raised bumps. It is also described as erythematous, or red. This type of rash is common in several diseases and medical conditions, including scarlet fever, measles, Ebola virus disease, rubella, secondary syphilis (Congenital syphilis, which is asymptomatic, the newborn may present this type of rash), erythrovirus ( parvovirus B19), chikungunya (alphavirus), zika, smallpox (which has been eradicated), varicella (when vaccinated persons exhibit symptoms from the modified form), heat rash, and sometimes in Dengue fever. It is also a common manifestation of a skin reaction to the antibiotic amoxicillin or chemotherapy drugs. Cutaneous infiltration of leukemic cells may ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lymphadenopathy
Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or consistency. Lymphadenopathy of an inflammatory type (the most common type) is lymphadenitis, producing swollen or enlarged lymph nodes. In clinical practice, the distinction between lymphadenopathy and lymphadenitis is rarely made and the words are usually treated as synonymous. Inflammation of the lymphatic vessels is known as lymphangitis. Infectious lymphadenitis affecting lymph nodes in the neck is often called scrofula. Lymphadenopathy is a common and nonspecific sign. Common causes include infections (from minor causes such as the common cold and post-vaccination swelling to serious ones such as HIV/AIDS), autoimmune diseases, and cancer. Lymphadenopathy is frequently idiopathic and self-limiting. Causes Lymph node enlargement is recognized as a common sign of infectious, autoimmune, or malignant disease. Examples may include: * Reactive: acute infection (''e.g.,'' ba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eschar
An eschar (; Greek: ''ἐσχάρᾱ'', ''eskhara''; Latin: ''eschara'') is a slough or piece of dead tissue that is cast off from the surface of the skin, particularly after a burn injury, but also seen in gangrene, ulcer, fungal infections, necrotizing spider bite wounds, tick bites associated with spotted fevers and exposure to cutaneous anthrax. The term ‘eschar’ is not interchangeable with ‘scab’. An eschar contains necrotic tissue whereas a scab is composed of dried blood and exudate. Black eschars are most frequently attributed in medicine to cutaneous anthrax (infection by '' Bacillus anthracis''), which may be contracted through herd animal exposure and also from ''Pasteurella multocida'' exposure in cats and rabbits. A newly identified human rickettsial infection, ''R. parkeri'' rickettsiosis, can be differentiated from Rocky Mountain spotted fever by the presence of an eschar at the site of inoculation. Eschar is sometimes called a ''black wound'' becau ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mediterranean Spotted Fever
The Mediterranean Sea is a sea connected to the Atlantic Ocean, surrounded by the Mediterranean Basin and almost completely enclosed by land: on the north by Western and Southern Europe and Anatolia, on the south by North Africa, and on the east by the Levant. The Sea has played a central role in the history of Western civilization. Geological evidence indicates that around 5.9 million years ago, the Mediterranean was cut off from the Atlantic and was partly or completely desiccated over a period of some 600,000 years during the Messinian salinity crisis before being refilled by the Zanclean flood about 5.3 million years ago. The Mediterranean Sea covers an area of about , representing 0.7% of the global ocean surface, but its connection to the Atlantic via the Strait of Gibraltar—the narrow strait that connects the Atlantic Ocean to the Mediterranean Sea and separates the Iberian Peninsula in Europe from Morocco in Africa—is only wide. The Mediterranean Sea enc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spotted Fever
A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by bacteria of the genus ''Rickettsia''. Typhus is a group of similar diseases also caused by ''Rickettsia'' bacteria, but spotted fevers and typhus are different clinical entities. Transmission process: When the tick latches on, it needs to be removed under 2 hours. If not noticed or unremoved it takes only 10 hours for the tick to transmit the (disease) to the human. The phrase apparently originated in Spain in the 17th century and was ‘loosely applied in England to typhus or any fever involving petechial eruptions.’ During the 17th and 18th centuries, it was thought to be "cousin-germane" to and herald of the bubonic plague, a disease which periodically afflicted the city of London and its environs during the 16th and 17th centuries, most notably during the Great Plague of 1665.Daniel Defoe, ''A Journal of the Plague Year'', ed. Louis Landa (Oxford, 2010) 219. Types of spotted fe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
