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Actifed
Actifed is a registered trademark for a combination antihistamine and nasal decongestant medication used for cold and allergy symptoms. Actifed was developed in 1958 by Burroughs Wellcome & Company (now part of GlaxoSmithKline), later Haleon. 2006 U.S. formula change The original formula for Actifed contained pseudoephedrine hydrochloride 60 mg as the nasal decongestant and triprolidine hydrochloride 2.5 mg as the antihistamine. However, in response to widespread laws requiring products containing pseudoephedrine to be kept behind the pharmacy counter, Pfizer changed Actifed's U.S. formula in late 2006 to contain phenylephrine HCl 10 mg as the nasal decongestant and chlorpheniramine maleate 4 mg as the antihistamine before the product was reacquired by GSK. Many users of the old formula have complained that the new formula is not as effective at relieving their symptoms. Other brands available behind the counter that use the old formula include Genac and Ap ...
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Haleon
Haleon plc is a British multinational consumer healthcare company with headquarters in Weybridge, England. It is the largest consumer healthcare business in the world, with brands including Sensodyne toothpaste, Panadol Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Common brand names include Tylenol and Panadol. At a standard dose, paracetamol only slightly decreases body temperature; it is inferio ... and Advil painkillers and Centrum (multivitamin), Centrum vitamins. The company is a global leader in over the counter medicines with a 7.3 percent market share. Haleon was established on 18 July 2022 as a corporate spin-off from GSK plc, GSK. Sir Dave Lewis (businessman), David Lewis is chairman, with Brian McNamara as CEO. Haleon is listed on the London Stock Exchange and is a component of the FTSE 100, with a secondary listing on the New York Stock Exchange. Annual sales amounted to around £10 billion across 120 ...
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Apollo 7
Apollo 7 (October 1122, 1968) was the first crewed flight in NASA's Apollo program, and saw the resumption of human spaceflight by the agency after the fire that killed the three Apollo 1 astronauts during a launch rehearsal test on January 27, 1967. The Apollo7 crew was commanded by Walter M. Schirra, with command module pilot Donn F. Eisele and lunar module pilot R. Walter Cunningham (so designated even though Apollo7 did not carry a Lunar Module). The three astronauts were originally designated for the second crewed Apollo flight, and then as backups for Apollo1. After the Apollo1 fire, crewed flights were suspended while the cause of the accident was investigated and improvements made to the spacecraft and safety procedures, and uncrewed test flights made. Determined to prevent a repetition of the fire, the crew spent long periods monitoring the construction of their Apollo command and service modules (CSM). Training continued over much of the pause that follo ...
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Pseudoephedrine
Pseudoephedrine (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent in higher doses. It was first characterized in 1889 by the German chemists Ladenburg and Oelschlägel, who used a sample that had been isolated from ''Ephedra vulgaris'' by the Merck pharmaceutical corporation of Darmstadt, Germany. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations, either as a single ingredient or (more commonly) in a fixed-dose combination with one or more additional active ingredients such as antihistamines, guaifenesin, dextromethorphan, paracetamol (acetaminophen) or an NSAID (such as aspirin or ibuprofen). Medical uses Pseudoephedrine is a stimulant, but it is well known for shrinking swollen nasal mucous membranes, so it is often used as a decongestant. It reduces tissue hyperemia, ede ...
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Triprolidine
Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. As with many antihistamines, the most common side effect is drowsiness. It was patented in 1948 and came into medical use in 1953. See also *Benztropine *Pseudoephedrine Pseudoephedrine (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent in higher doses. It was first characteri ... * UK-9040 References Alkene derivatives H1 receptor antagonists Muscarinic antagonists 2-Pyridyl compounds Pyrrolidines 4-Tolyl compounds {{respiratory-system-drug-stub ...
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Pseudoephedrine Hydrochloride
Pseudoephedrine (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent in higher doses. It was first characterized in 1889 by the German chemists Ladenburg and Oelschlägel, who used a sample that had been isolated from ''Ephedra vulgaris'' by the Merck pharmaceutical corporation of Darmstadt, Germany. The salts pseudoephedrine hydrochloride and pseudoephedrine sulfate are found in many over-the-counter preparations, either as a single ingredient or (more commonly) in a fixed-dose combination with one or more additional active ingredients such as antihistamines, guaifenesin, dextromethorphan, paracetamol (acetaminophen) or an NSAID (such as aspirin or ibuprofen). Medical uses Pseudoephedrine is a stimulant, but it is well known for shrinking swollen nasal mucous membranes, so it is often used as a decongestant. It reduces tissue hyperemia, edem ...
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Triprolidine Hydrochloride
Triprolidine is an Over-the-counter drug, over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergy, allergies and is sometimes combined with other common cold, cold medications designed to provide general relief for influenza, flu-like symptoms. As with many antihistamines, the most common Adverse effect (medicine), side effect is drowsiness. It was patented in 1948 and came into medical use in 1953. See also *Benztropine *Pseudoephedrine *UK-9040 References

Alkene derivatives H1 receptor antagonists Muscarinic antagonists 2-Pyridyl compounds Pyrrolidines 4-Tolyl compounds {{respiratory-system-drug-stub ...
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Registered Trademark
The registered trademark symbol, , is a typographic symbol that provides notice that the preceding word or symbol is a trademark or service mark that has been registered with a national trademark office. A trademark is a symbol, word, or words legally registered or established by use as representing a company, product or service.For example, Unregistered trademarks can instead be marked with the trademark symbol, , while unregistered service marks are marked with the service mark symbol, . The proper manner to display these symbols is immediately following the mark; the symbol is commonly in superscript style, but that is not legally required. In many jurisdictions, only registered trademarks confer easily defended legal rights. In the US, the registered trademark symbol was originally introduced in the Trademark Act of 1946. Because the symbol is not commonly available on typewriters (or ASCII), it was common to approximate it with the characters (or ). An example of a ...
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Over-the-counter
Over-the-counter (OTC) drugs are medicines sold directly to a consumer without a requirement for a prescription from a healthcare professional, as opposed to prescription drugs, which may be supplied only to consumers possessing a valid prescription. In many countries, OTC drugs are selected by a regulatory agency to ensure that they contain ingredients that are safe and effective when used without a physician's care. OTC drugs are usually regulated according to their active pharmaceutical ingredient (API) rather than final products. By regulating APIs instead of specific drug formulations, governments allow manufacturers the freedom to formulate ingredients, or combinations of ingredients, into proprietary mixtures. The term ''over-the-counter'' (''OTC'') refers to a medication that can be purchased without a medical prescription. In contrast, prescription drugs require a prescription from a doctor or other health care professional and should only be used by the prescribe ...
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Apollo 12
Apollo 12 (November 14–24, 1969) was the sixth crewed flight in the United States Apollo program and the second to land on the Moon. It was launched on November 14, 1969, by NASA from the Kennedy Space Center, Florida. Commander Pete Conrad, Charles "Pete" Conrad and Lunar Module Pilot Alan Bean, Alan L. Bean performed just over one day and seven hours of lunar surface activity while Command Module Pilot Richard F. Gordon Jr., Richard F. Gordon remained in lunar orbit. Apollo 12 would have attempted the first lunar landing had Apollo 11 failed, but after the success of Neil Armstrong's mission, Apollo 12 was postponed by two months, and other Apollo missions also put on a more relaxed schedule. More time was allotted for geologic training in preparation for Apollo 12 than for Apollo 11, Conrad and Bean making several geology field trips in preparation for their mission. Apollo 12's spacecraft and launch vehicle were almost identical to Apollo 11's. One addition was hammocks ...
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United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ...
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Chlorpheniramine
Chlorphenamine (CP, CPM), also known as chlorpheniramine, is an antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis (hay fever). It is taken by mouth. The medication takes effect within two hours and lasts for about 4-6. Common side effects include sleepiness, restlessness, and weakness. Other side effects may include dry mouth and wheeziness. It is a first-generation antihistamine and works by blocking the H1 receptor. Chlorpheniramine was patented in 1948 and came into medical use in 1949. It is available as a generic medication and over the counter. Medical uses Combination products Chlorphenamine is often combined with phenylpropanolamine to form an allergy medication with both antihistamine and decongestant properties, though phenylpropanolamine is no longer available in the US after studies showed it increased the risk of stroke in young women. Chlorphenamine remains available with no such risk. Chlorphenamine may be combined wi ...
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