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Ablomin
Ablomin is a toxin present in the venom of the Japanese Mamushi snake, which blocks L-type voltage-gated calcium channels. Etymology The protein ablomin is a component of the venom of the Japanese Mamushi snake, ''Gloydius blomhoffii''. The term ‘ablomin’ is an acronym derived from ''Agkistrodon blomhoffi'', an old name for this snake. Sources The protein can be found in the venom of the Japanese Mamushi snake, a member of the Viperidae family. Chemistry Ablomin is part of the Cystein-Rich Secretory Protein (CRISP) family. CRISPs comprise a particular group of snake venom proteins distributed among the venom of several families of snakes, such as elapids, colubrids and vipers. The protein exists of 240 amino acids, coded by an mRNA of 1336 base pairs. Structurally, it is composed of three distinct regions: an N-terminal protein domain, a hinge region and a C-terminal cystein-rich domain. It has a molecular mass of 25 kDa The dalton or unified atomic mass unit (sy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ophanin
Ophanin is a toxin found in the venom of the King Cobra (''Ophiophagus hannah''), which lives throughout South East Asia. This toxin belongs to the cysteine-rich secretory protein (CRISP) family. Ophanin weakly blocks the contraction of smooth muscles elicited by high potassium-induced depolarization, suggesting that it inhibits voltage-dependent calcium channels. Etymology The toxin was named ''ophanin'' after the snake whose venom it is derived from, the King Cobra (''Ophiophagus hannah''). Sources Ophanin is produced in the venom glands of the King Cobra (''O. Hannah''). Although the venom has relatively low toxicity, this is compensated by the high amounts of it injected into the prey for each bite. Chemistry Structure Ophanin was successfully isolated from ''O. Hannah'' venom by gel filtration and cation-exchange chromatography. Its molecular weight is 25 kDa (from positions 19 – 239), which conforms to the molecular mass predicted from its cDNA sequences. Hom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Latisemin
Latisemin is a cysteine-rich secretory protein that can be isolated from the venom of the Black-banded sea krait, a sea snake indigenous to the warmer waters of the western Pacific Ocean. It is a toxin that inhibits cyclic nucleotide-gated ion channels and blocks L-type calcium channels, thereby reducing smooth muscle contraction. Sources Latisemin is a component of the venom produced by the Erabu sea snake (''Laticauda semifasciata'') of the family Elapidae and the Laticauda genus. These sea snakes inhabit coral reef areas in the seas of Southern Japan, Southeast Asia, and Australia. Though highly venomous, this snake is comparatively unaggressive, and is in fact caught and eaten in Erabu soup in Japan. Biochemistry Latisemin has a molecular weight of 24 kDa and consists of 217 amino acids. It belongs to the CRISP (cysteine-rich secretory protein) glycoprotein subfamily, which are single chain polypeptides containing strictly conserved cysteines (cysteines not oxidised to c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mamushi
''Gloydius blomhoffii'', commonly known as the mamushi,Mehrtens JM (1987). ''Living Snakes of the World in Color''. New York: Sterling Publishers. 480 pp. . Japanese moccasin, Japanese pit viper, Qichun snake, Salmusa or Japanese mamushi,Gumprecht A, Tillack F, Orlov NL, Captain A, Ryabov S (2004). ''Asian Pitvipers''. First Edition. Berlin: Geitje Books. 368 pp. . is a venomous pit viper species found in Japan. It was once considered to have 4 subspecies, but it is now considered monotypic. This species, along with the yamakagashi (''Rhabdophis tigrinus'') and the Okinawan habu (''Protobothrops flavoviridis''), are the most venomous snakes in Japan. Every year, 2000–3000 people in Japan are bitten by a mamushi. Bitten victims typically require one week of treatment in a hospital. Severe bites require intensive care, and approximately 10 victims die annually. Etymology The specific name, ''blomhoffii'', is in honor of Jan Cock Blomhoff, who was director of the Dutch trading ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gloydius Blomhoffii
''Gloydius blomhoffii'', commonly known as the mamushi,Mehrtens JM (1987). ''Living Snakes of the World in Color''. New York: Sterling Publishers. 480 pp. . Japanese moccasin, Japanese pit viper, Qichun snake, Salmusa or Japanese mamushi,Gumprecht A, Tillack F, Orlov NL, Captain A, Ryabov S (2004). ''Asian Pitvipers''. First Edition. Berlin: Geitje Books. 368 pp. . is a venomous pit viper species found in Japan. It was once considered to have 4 subspecies, but it is now considered monotypic. This species, along with the yamakagashi (''Rhabdophis tigrinus'') and the Okinawan habu (''Protobothrops flavoviridis''), are the most venomous snakes in Japan. Every year, 2000–3000 people in Japan are bitten by a mamushi. Bitten victims typically require one week of treatment in a hospital. Severe bites require intensive care, and approximately 10 victims die annually. Etymology The specific name, ''blomhoffii'', is in honor of Jan Cock Blomhoff, who was director of the Dutch trading ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Latisemin
Latisemin is a cysteine-rich secretory protein that can be isolated from the venom of the Black-banded sea krait, a sea snake indigenous to the warmer waters of the western Pacific Ocean. It is a toxin that inhibits cyclic nucleotide-gated ion channels and blocks L-type calcium channels, thereby reducing smooth muscle contraction. Sources Latisemin is a component of the venom produced by the Erabu sea snake (''Laticauda semifasciata'') of the family Elapidae and the Laticauda genus. These sea snakes inhabit coral reef areas in the seas of Southern Japan, Southeast Asia, and Australia. Though highly venomous, this snake is comparatively unaggressive, and is in fact caught and eaten in Erabu soup in Japan. Biochemistry Latisemin has a molecular weight of 24 kDa and consists of 217 amino acids. It belongs to the CRISP (cysteine-rich secretory protein) glycoprotein subfamily, which are single chain polypeptides containing strictly conserved cysteines (cysteines not oxidised to c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cysteine-rich Secretory Protein
Cysteine-rich secretory proteins, often abbreviated as CRISPs, are a group of glycoproteins. They are a subgroup of the CRISP, antigen 5 and Pr-1 (CAP) protein superfamily and also contain a domain related to the ShK toxins. They are substantially implicated in the functioning of the mammalian reproductive system. CRISPs are also found in a variety of snake venoms where they inhibit both smooth muscle contraction and cyclic nucleotide-gated ion channels. Structure CRISPs contain two domains joined by a hinge region. The larger domain is a CAP-like 'Pathogenesis-related 1' domain (PR-1), followed by the smaller ShK-like 'Cysteine-Rich Domain' (CRD). CRISPs are glycoproteins, with a number of carbohydrate glycans covalently attached to amino acid side-chains on their surface via glycosylation. The primary structure is also rich in cysteine that form disulfide bonds, particularly in the hinge region and CRD. Mammalian reproduction CRISPs are found in the testes and epidid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Piscivorin
Piscivorin is a component of snake venom secreted by the Eastern Cottonmouth (''Agkistrodon piscivorus piscivorus''). It is a member of the cysteine-rich secretory protein (CRISP) family, which blocks voltage-dependent calcium channels. Etymology The name of piscivorin comes from the snake species name piscivorus, which is derived from the Latin words ''pisces'' and ''vorare'', meaning 'fish' and 'to devour' respectively. Sources Piscivorin is produced in the venom glands of the Eastern Cottonmouth snake (''Agkistrodon piscivorus piscivorus''), which populates the Eastern United States. Typically, crude venom from the Eastern Cottonmouth contains approximately 1.25% of piscivorin. Biochemistry Piscivorin belongs to the cysteine-rich secretory protein (CRISP) family, which are secreted as single-chain proteins with molecular masses between 20 and 30 kDa. They display significant amino acid sequence homology. Sixteen cysteine residues, forming 8 disulfide bonds, are strictly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japanese Mamushi
''Gloydius blomhoffii'', commonly known as the mamushi,Mehrtens JM (1987). ''Living Snakes of the World in Color''. New York: Sterling Publishers. 480 pp. . Japanese moccasin, Japanese pit viper, Qichun snake, Salmusa or Japanese mamushi,Gumprecht A, Tillack F, Orlov NL, Captain A, Ryabov S (2004). ''Asian Pitvipers''. First Edition. Berlin: Geitje Books. 368 pp. . is a venomous pit viper species found in Japan. It was once considered to have 4 subspecies, but it is now considered monotypic. This species, along with the yamakagashi (''Rhabdophis tigrinus'') and the Okinawan habu (''Protobothrops flavoviridis''), are the most venomous snakes in Japan. Every year, 2000–3000 people in Japan are bitten by a mamushi. Bitten victims typically require one week of treatment in a hospital. Severe bites require intensive care, and approximately 10 victims die annually. Etymology The specific name, ''blomhoffii'', is in honor of Jan Cock Blomhoff, who was director of the Dutch trading c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxin
A toxin is a naturally occurring organic poison produced by metabolic activities of living cells or organisms. Toxins occur especially as a protein or conjugated protein. The term toxin was first used by organic chemist Ludwig Brieger (1849–1919) and is derived from the word toxic. Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their toxicity, ranging from usually minor (such as a bee sting) to potentially fatal even at extremely low doses (such as botulinum toxin). Toxins are largely secondary metabolites, which are organic compounds that are not directly involved in an organism's growth, development, or reproduction, instead often aiding it in matters of defense. Terminology Toxins are often distinguished from other chemical agents strictly based on their biological origin. Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ion Channel Toxins
An ion () is an atom or molecule with a net electrical charge. The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by convention. The net charge of an ion is not zero because its total number of electrons is unequal to its total number of protons. A cation is a positively charged ion with fewer electrons than protons while an anion is a negatively charged ion with more electrons than protons. Opposite electric charges are pulled towards one another by electrostatic force, so cations and anions attract each other and readily form ionic compounds. Ions consisting of only a single atom are termed atomic or monatomic ions, while two or more atoms form molecular ions or polyatomic ions. In the case of physical ionization in a fluid (gas or liquid), "ion pairs" are created by spontaneous molecule collisions, where each generated pair consists of a free electron and a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triflin
Triflin is a cysteine-rich secretory protein (CRISP), which is excreted by the venom gland of the Habu snake (''Trimeresurus flavoviridis''). Triflin reduces high potassium-induced smooth muscle contraction, suggesting a blocking effect on L-type calcium channels. Sources Triflin is a toxin derived from snake venom. The toxin is produced in the gland of the Habu snake, ''Trimeresurus flavoviridis''. Chemistry Triflin is a cysteine-rich secretory protein, which means it belongs to the CRISP family. This is a group of single chain polypeptides found in various organisms. Triflin weighs 25 kDa and consists of 221 amino-acid residues. The first 163 residues of the N-terminal domain forms an α-β-α sandwich core. This domain is comparable with group 1 plant pathogenesis-related protein (PR-1). The C-terminal domain, has five disulfide bridges. This domain is responsible for the selectivity of the protein and consists of two subdomains: N-terminal subdomain (Cys 167 to Cys 179) a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclic Nucleotide-gated Channel Alpha 1
Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein. Heterologously expressed CNGA1 can form a functional channel that is permeable to calcium. In rod photoreceptors, however, CNGA1 forms a heterotetramer with CNGB1 in a 3:1 ratio. The addition of the CNGB1 channel imparts altered properties including more rapid channel kinetics and greater cAMP-activated current. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/B1 channels and, therefore, hyperpolarization of the membrane potential. See also * Cyclic nucleotide-gated ion channel Cycle, cycles, or cyclic may refer to: Anthropology and social sciences * Cyclic history, a theory of history * Cyclical theory, a theory of American political history associated with Arthur Schlesinger, Sr. * Social cycle, various cycles in soc ... References Further reading * * * * * * * * * * * * * * * External links Gene ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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