|
ATC Code B01
B01A Antithrombotic agents B01AA Vitamin K antagonists :B01AA01 Dicoumarol :B01AA02 Phenindione :B01AA03 Warfarin :B01AA04 Phenprocoumon :B01AA07 Acenocoumarol :B01AA08 Ethyl biscoumacetate :B01AA09 Clorindione :B01AA10 Diphenadione :B01AA11 Tioclomarol :B01AA12 Fluindione B01AB Heparin group :B01AB01 Heparin :B01AB02 Antithrombin III :B01AB04 Dalteparin :B01AB05 Enoxaparin :B01AB06 Nadroparin :B01AB07 Parnaparin :B01AB08 Reviparin :B01AB09 Danaparoid :B01AB10 Tinzaparin :B01AB11 Sulodexide :B01AB12 Bemiparin :B01AB51 Heparin, combinations B01AC Platelet aggregation inhibitors excluding heparin :B01AC01 Ditazole :B01AC02 Cloricromen :B01AC03 Picotamide :B01AC04 Clopidogrel :B01AC05 Ticlopidine :B01AC06 Acetylsalicylic acid :B01AC07 Dipyridamole :B01AC08 Carbasalate calcium :B01AC09 Epoprostenol :B01AC10 Indobufen :B01AC11 Iloprost :B01AC13 Abciximab :B01AC15 Aloxiprin :B01AC16 Eptifibatide :B01AC17 Tirofiban :B01AC18 Triflusal :B01AC19 Beraprost :B01AC21 Treprostinil :B0 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vitamin K
Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation (K from ''Koagulation'', German for "coagulation") or for controlling binding of calcium in bones and other tissues. The complete synthesis involves final modification of these so-called "Gla proteins" by the enzyme gamma-glutamyl carboxylase that uses vitamin K as a cofactor. Vitamin K is used in the liver as the intermediate VKH2 to deprotonate a glutamate residue and then is reprocessed into vitamin K through a vitamin K oxide intermediate. The presence of uncarboxylated proteins indicates a vitamin K deficiency. Carboxylation allows them to bind (chelate) calcium ions, which they cannot do otherwise. Without vitamin K, blood coagulation is seriously impaired, and uncontrolled bleeding occurs. Research suggests that deficiency of v ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reviparin
Reviparin is an antithrombotic and belongs to the group of low molecular weight heparins (LMWH). Medical uses * Prevention of blood clots * Prophylaxis of perioperative thromboembolism * Treatment of DVT with or without pulmonary embolism (PE) * Prophylaxis of acute thrombotic events after percutaneous transluminal coronary angioplasty (PTCA) Chemistry Reviparin is a low molecular weight heparin obtained by nitrous acid Nitrous acid (molecular formula ) is a weak and monoprotic acid known only in Solution (chemistry), solution, in the gas phase and in the form of nitrite () salts. Nitrous acid is used to make diazonium salts from amines. The resulting diazoni ... depolymerization of heparin extracted from porcine intestinal mucosa. Its structure is characterized, for the most part, by a group of 2-''O''-sulfo-α-lidopyranosuronic acid. The average molecular weight is about 3900 daltons. References External links * * Heparins {{blood-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbasalate Calcium
Carbasalate calcium is an analgesic, antipyretic, and anti-inflammatory drug, as well as a platelet aggregation inhibitor. It is a chelate of calcium acetylsalicylate (the calcium salt of aspirin) and urea Urea, also known as carbamide, is an organic compound with chemical formula . This amide has two amino groups (–) joined by a carbonyl functional group (–C(=O)–). It is thus the simplest amide of carbamic acid. Urea serves an important .... References Antiplatelet drugs Combination drugs {{analgesic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dipyridamole
Dipyridamole (trademarked as Persantine and others) is a nucleoside transport inhibitor and a PDE3 inhibitor medication that inhibits blood clot formation when given chronically and causes blood vessel dilation when given at high doses over a short time. Medical uses * Dipyridamole is used to dilate blood vessels in people with peripheral arterial disease and coronary artery disease * Dipyridamole has been shown to lower pulmonary hypertension without significant drop of systemic blood pressure * It inhibits formation of pro-inflammatory cytokines (MCP-1, MMP-9) in vitro and results in reduction of hsCRP in patients. * It inhibits proliferation of smooth muscle cells in vivo and modestly increases unassisted patency of synthetic arteriovenous hemodialysis grafts. * It increases the release of tissue plasminogen activator from brain microvascular endothelial cells. * It results in an increase of 13-hydroxyoctadecadienoic acid and decrease of 12-hydroxyeicosatetraenoic acid in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acetylsalicylic Acid
Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. For pain or fever, effects typically begin within 30 minutes. Aspirin works similarly to other NSAIDs but also suppresses the normal functioning of platelets. One common adverse effect is an upset stomach. More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on other blood thinners. Aspirin is not recommended in the last part of pregnancy. It is not generally recommended in children with infections because of the risk of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ticlopidine
Ticlopidine, sold under the brand name Ticlid, is a medication used to reduce the risk of thrombotic strokes. It is an antiplatelet drug in the thienopyridine family which is an adenosine diphosphate (ADP) receptor inhibitor. Research initially showed that it was useful for preventing strokes and coronary stent occlusions. However, because of its rare but serious side effects of neutropenia and thrombotic thrombocytopenic purpura it was primarily used in patients in whom aspirin was not tolerated, or in whom dual antiplatelet therapy was desirable. With the advent of newer and safer antiplatelet drugs such as clopidogrel and ticagrelor, its use remained limited. It was patented in 1973 and approved for medical use in 1978. Medical uses Ticlopidine is Indication (medicine), indicated for the prevention of strokes and when combined with aspirin, for people with a new coronary stent to prevent closure. Stroke Ticlopidine is considered a second-line option for the prevention o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clopidogrel
Clopidogrel — sold under the brand name Plavix, among others — is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent (dual antiplatelet therapy). It is taken by mouth. Its effect starts about two hours after intake and lasts for five days. Common side effects include headache, nausea, easy bruising, itching, and heartburn. More severe side effects include bleeding and thrombotic thrombocytopenic purpura. While there is no evidence of harm from use during pregnancy, such use has not been well studied. Clopidogrel is in the thienopyridine-class of antiplatelets. It works by irreversibly inhibiting a receptor called P2Y12 on platelets. Clopidogrel was patented in 1982, and approved for medical use in 1997. It is on the World Health Organization's List of Essential Medicines. In 2020, it was the 29th most commonly ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Picotamide
Picotamide is a platelet aggregation inhibitor. It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor. Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease. References External links * Andrea Celestini and Francesco VioliA review of picotamide in the reduction of cardiovascular events in diabetic patients (PubMed) Antiplatelet drugs 3-Pyridyl compounds Benzamides Phenol ethers {{blood-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cloricromen
Cloricromen is a platelet aggregation inhibitor. Coronary vasodilator. Synthesis : Base catalyzed alkylation of ethyl acetoacetate (1) with 2-chlorotriethylamine (2) gives compound (3). Separately, disulfonation of resorcinol (4) with 96% sulfuric acid gives the disulfonic acid (5). This is chlorinated with potassium chlorate to give 5-chloro-4,6-dihydroxybenzene-1,3-disulfonic acid (6). Removal of the sulfonate groups in dilute acid then gives 2-chlororesorcinol (7). An acid-catalyzed condensation reaction between (3) and (7) produces the intermediate (8). Ether formation at its Phenols, phenolic hydroxyl group with ethyl bromoacetate (9) completes the synthesis of cloricromen. See also *Carbocromen is the analogue without the chlorine substituent References Antiplatelet drugs Coumarin drugs Chloroarenes Diethylamino compounds {{blood-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ditazole
Ditazole is a non-steroidal anti-inflammatory agent with analgesic and antipyretic activity similar to phenylbutazone. It is also a platelet aggregation inhibitor which is marketed in Spain and Portugal Portugal, officially the Portuguese Republic ( pt, República Portuguesa, links=yes ), is a country whose mainland is located on the Iberian Peninsula of Southwestern Europe, and whose territory also includes the Atlantic archipelagos of ... under the trade name Ageroplas. References Oxazoles Antiplatelet drugs Ethanolamines {{blood-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Platelet
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot. Platelets have no cell nucleus; they are fragments of cytoplasm that are derived from the megakaryocytes of the bone marrow or lung, which then enter the circulation. Platelets are found only in mammals, whereas in other vertebrates (e.g. birds, amphibians), thrombocytes circulate as intact mononuclear cells. One major function of platelets is to contribute to hemostasis: the process of stopping bleeding at the site of interrupted endothelium. They gather at the site and, unless the interruption is physically too large, they plug the hole. First, platelets attach to substances outside the interrupted endothelium: ''adhesion''. Second, they change shape, turn on receptors and secrete chemical messengers: ''activatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bemiparin
Bemiparin (trade names Ivor and Zibor, among others) is an antithrombotic and belongs to the group of low molecular weight heparins (LMWH). Medical uses Bemiparin is used for the prevention of thromboembolism after surgery, and to prevent blood clotting in the extracorporeal circuit in haemodialysis. Contraindications The medication is contraindicated in patients with a history of heparin-induced thrombocytopenia with or without disseminated intravascular coagulation; acute bleeding or risk of bleeding; injury or surgery of the central nervous system, eyes or ears; severe liver or pancreas impairment; and acute or subacute bacterial endocarditis. Interactions No interaction studies have been conducted. Drugs that are expected to increase the risk of bleeding in combination with bemiparin include other anticoagulants, aspirin and other NSAIDs, antiplatelet drugs, and corticosteroids. Chemistry Like semuloparin, bemiparin is classified as an ultra-LMWH because of its low m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
