Picotamide is a

platelet aggregation inhibitor An antiplatelet drug (antiaggregant), also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation and inhibit thrombus formation. They are effectiv ...

. It works as a

thromboxane synthase inhibitor Thromboxane A synthase 1 (, platelet, cytochrome P450, family 5, subfamily A), also known as TBXAS1, is a cytochrome P450 enzyme that, in humans, is encoded by the ''TBXAS1'' gene. Function This gene encodes a member of the cytochrome P450 supe ...

and a

thromboxane receptor inhibitor The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the ''TBXA2R'' gene, The thromboxane receptor is one among the five classes of prostanoid receptors and was the first eicosanoid rec ...

, the latter by modifying cellular responses to activation of the

thromboxane receptor The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the ''TBXA2R'' gene, The thromboxane receptor is one among the five classes of prostanoid receptors and was the first eicosanoid rec ...

. Picotamide is licensed in Italy for the treatment of clinical arterial thrombosis and peripheral artery disease.

References

External links

* Andrea Celestini and Francesco Violi
A review of picotamide in the reduction of cardiovascular events in diabetic patients
(PubMed) Antiplatelet drugs 3-Pyridyl compounds Benzamides Phenol ethers {{blood-drug-stub