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AL-1095
AL-1095, is a centrally acting stimulant drug with comparable effects to amphetamine, developed by Bristol in the 1970s. Synthesis The first-step is a mixed-aldol condensation between 3-quinuclidinone 731-38-2(1) and benzaldehyde (2) gives 2-benzylidene-3-oxoquinuclidine 4123-89-5(3). The conjugate addition of the Grignard reagent formed from 4-bromochlorobenzene 06-39-8(4) to the enone gives the benzhydryl (5). MPV reduction of the carbonyl gives the syn stereoisomers, whereas borohydride gave trans. Both diastereoisomers are active but in only one of the enantiomers. See also * Butyltolylquinuclidine * Desoxypipradrol * SCH-5472 SCH-5472. is a stimulant drug developed by Schering-Plough in the 1950s. Synthesis Potassium amide was made from the reaction of potassium metal with liquid ammonia. The coupling between the carbanion created from diphenylmethane 01-81-5(1) a ... References Stimulants 2-Benzylpiperidines Quinuclidines Chloroarenes Secondary alcoh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Butyltolylquinuclidine
2-Butyl-3-(p-tolyl)quinuclidine (BTQ) is a stimulant Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and inv ... DRI. It is one of a number of substituted quinuclidine derivatives developed as potential medications for the treatment of cocaine abuse, and produces similar effects to cocaine in animal studies, although milder and longer-lasting. See also * AL-1095 References 2-Benzylpiperidines Stimulants Dopamine reuptake inhibitors Quinuclidines {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Desoxypipradrol
Desoxypipradrol, also known as 2-diphenylmethylpiperidine (2-DPMP), is a drug developed by Ciba in the 1950s which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). Chemistry Desoxypipradrol is closely related on a structural level to the compounds methylphenidate and pipradrol, all three of which share a similar pharmacological action. Of these three piperidines, desoxypipradrol has the longest elimination half-life, as it is a highly lipophilic molecule lacking polar functional groups that are typically targeted by metabolic enzymes, giving it an extremely long duration of action when compared to most psychostimulants. Methylphenidate, on the other hand, is a short-acting compound, as it possesses a methyl-ester moiety that is easily cleaved, forming a highly polar acid group, while pipradrol is intermediate in duration, possessing a hydroxyl group which can be conjugated (e.g. with glucuronide) to increase its hydrophilicity and facilitate excretion, but no eas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SCH-5472
SCH-5472. is a stimulant drug developed by Schering-Plough in the 1950s. Synthesis Potassium amide was made from the reaction of potassium metal with liquid ammonia. The coupling between the carbanion created from diphenylmethane 01-81-5(1) and ethyl 2-furoate 14-99-3 335-40-6(2) gives 2-furyl benzhydryl ketoneCID:63950182(3). The was reacted with concentrated liquid ammonia in methanol solvent in an autoclave. The product of this step was 2-benzhydrylpyridin-3-olCID:125491889(4). Reduction of the pyridine gave 2-(diphenylmethyl)piperidin-3-olCID:209477(5). See also * AL-1095 * Desoxypipradrol Desoxypipradrol, also known as 2-diphenylmethylpiperidine (2-DPMP), is a drug developed by Ciba in the 1950s which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). Chemistry Desoxypipradrol is closely related on a structural lev ... * Difemetorex References Stimulants 2-Benzylpiperidines {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have Sympathomimetic drug, sympathomimetic effects. Stimulants are widely used throughout the world as prescription medicines as well as without a prescription (either legally or Prohibition (drugs), illicitly) as performance-enhancing substance, performance-enhancing or recreational drug use, recreational drugs. Among narcotics, stimulants produce a noticeable crash or ''Comedown (drugs), comedown'' at the end of their effects. The most frequently prescribed stimulants as of 2013 were lisdexamfetamine (Vyvanse), methylphenidate (Ritalin), and amphetamine (Adderall). It was estimated in 2015 that the percentage of the world population that had used cocaine during a year was 0.4%. For the category "amphetamines and p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amphetamine
Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used as a recreational drug. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine. ''Amphetamine'' properly refers to a specific chemical, the racemic free base, which is equal parts of the two enantiomers in their pure amine forms. The term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic performance enhancer and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. It is a prescription drug in many countries, and unauthorized possession and distribution of amphetamine are often tightly controlled due to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AL-1095 Synthesis
Alabama's 1st congressional district is a United States congressional district in Alabama, which elects a representative to the United States House of Representatives. It includes the entirety of Washington, Mobile, Baldwin, Escambia and Monroe counties, and also includes part of Clarke County. The largest city in the district is Mobile. It is currently represented by Republican Jerry Carl. Character Mobile, Alabama is the focus of this district, which extends north along the Tombigbee and Alabama rivers. Timber production remains the biggest source of contributions to the local economy, however recently gulf coast condominium developments in Baldwin county represent new economic possibilities. Politically, this area was one of the first in Alabama to shake off its Democratic roots. It was one of five districts to swing Republican in 1964, when Barry Goldwater swept the state. The GOP has held the district in every House election since then, usually by landslide m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzaldehyde
Benzaldehyde (C6H5CHO) is an organic compound consisting of a benzene ring with a formyl substituent. It is the simplest aromatic aldehyde and one of the most industrially useful. It is a colorless liquid with a characteristic almond-like odor. The primary component of bitter almond oil, benzaldehyde can be extracted from a number of other natural sources. Synthetic benzaldehyde is the flavoring agent in imitation almond extract, which is used to flavor cakes and other baked goods. History Benzaldehyde was first extracted in 1803 by the French pharmacist Martrès. His experiments focused on elucidating the nature of amygdalin, the poisonous material found in bitter almonds, the fruit of ''Prunus dulcis''. Further work on the oil by Pierre Robiquet and Antoine Boutron-Charlard, two French chemists, produced benzaldehyde. In 1832, Friedrich Wöhler and Justus von Liebig first synthesized benzaldehyde. Production As of 1999, 7000 tonnes of synthetic and 100 tonnes of natural b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bromochlorobenzene
Bromochlorobenzene is any of three different positional isomers consisting of a bromine atom and a chlorine atom as substituents on a benzene ring. All three have been synthesized by various routes: * 1-Bromo-2-chlorobenzene: from 2- chloroaniline, via diazotization followed by a Sandmeyer reaction * 1-Bromo-3-chlorobenzene: by (3-chlorophenyl)trimethylgermanium by electrophilic substitution * 1-Bromo-4-chlorobenzene: **From a derivative of (4-bromophenyl)silane using ''N''-bromosuccinimide **From 4-chlorophenol 4-Chlorophenol is an organic compound with the formula ClC6H4OH. It is one of three monochlorophenol isomers. It is a colorless or white solid that melts easily and exhibits significant solubility in water. Its pKa is 9.14. Preparation and reac ... using triphenylphosphine dibromide or phenylphosphorus tetrachloride References {{Authority control Chlorobenzenes Bromoarenes C ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MPV Reduction
MPV or mpv may refer to: Vehicles Road * Multi-purpose vehicle, a car class ("minivan" in North America) ** Compact MPV, a medium-sized MPV ** Mini MPV, a small MPV *Mazda MPV, a minivan model Maritime * Multi-purpose vessel, a ship built to carry a range of cargoes Military * Mine Protected Vehicle (other) ** Mahindra Mine Protected Vehicle, an Indian armored personnel carrier ** Okapi MPV, a South African mine-protected vehicle Rail * Windhoff MPV, a multi-unit train for infrastructure maintenance ** British Rail MPV, a Windoff MPV version used in the United Kingdom Computer software * mpv (media player), a command-line, audio/video playback program * Multi-Purpose Viewer, an image generator for serious simulation Science and medicine * Mean platelet volume, in blood testing, a measure of platelet size * Meerwein–Ponndorf–Verley reduction, a chemical reaction reducing ketones and aldehydes * Monkeypox virus, a pathogen of humans and other euarchontoglires Othe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulants
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have Sympathomimetic drug, sympathomimetic effects. Stimulants are widely used throughout the world as prescription medicines as well as without a prescription (either legally or Prohibition (drugs), illicitly) as performance-enhancing substance, performance-enhancing or recreational drug use, recreational drugs. Among narcotics, stimulants produce a noticeable crash or ''Comedown (drugs), comedown'' at the end of their effects. The most frequently prescribed stimulants as of 2013 were lisdexamfetamine (Vyvanse), methylphenidate (Ritalin), and amphetamine (Adderall). It was estimated in 2015 that the percentage of the world population that had used cocaine during a year was 0.4%. For the category "amphetamines and p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quinuclidines
Quinuclidine is an organic compound and a bicyclic amine and used as a catalyst and a chemical building block. It is a strong base with p''K''a of the conjugate acid of 11.0.{{cite journal , title=Azatriquinanes: Synthesis, Structure, and Reactivity , author1=Hext, N. M. , author2=Hansen, J. , author3=Blake, A. J. , author4=Hibbs, D. E. , author5=Hursthouse, M. B. , author6=Shishkin, O. V. , author7=Mascal, M. , journal=J. Org. Chem. , year=1998 , volume=63 , issue=17 , pages=6016–6020 , doi=10.1021/jo980788s , pmid=11672206 It can be prepared by reduction of quinuclidone. In alkane solvents quinuclidine is a Lewis base that forms adducts with a variety of Lewis acids. The compound is structurally related to DABCO, in which the other bridgehead is also nitrogen, and to tropane, which has a slightly different carbon frame. Quinuclidine is found as a structural component of some biomolecules including quinine Quinine is a medication used to treat malaria and babesiosis. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
