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Potassium amide was made from the reaction of potassium metal with liquid ammonia. The coupling between the carbanion created from diphenylmethane 01-81-5(1) and ethyl 2-furoate 14-99-3 335-40-6(2) gives 2-furyl benzhydryl ketone
CID:63950182
(3). The was reacted with concentrated liquid ammonia in methanol solvent in an autoclave. The product of this step was 2-benzhydrylpyridin-3-ol
CID:125491889
(4). Reduction of the pyridine gave 2-(diphenylmethyl)piperidin-3-ol
CID:209477
(5).
stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and inv ...
drug developed by Schering-Plough in the 1950s.Synthesis
Potassium amide was made from the reaction of potassium metal with liquid ammonia. The coupling between the carbanion created from diphenylmethane 01-81-5(1) and ethyl 2-furoate 14-99-3 335-40-6(2) gives 2-furyl benzhydryl ketoneCID:63950182
(3). The was reacted with concentrated liquid ammonia in methanol solvent in an autoclave. The product of this step was 2-benzhydrylpyridin-3-ol
CID:125491889
(4). Reduction of the pyridine gave 2-(diphenylmethyl)piperidin-3-ol
CID:209477
(5).
See also
*AL-1095
AL-1095, is a centrally acting stimulant drug with comparable effects to amphetamine, developed by Bristol in the 1970s. Synthesis
The first-step is a mixed-aldol condensation between 3-quinuclidinone 731-38-2(1) and benzaldehyde (2) gives 2-b ...
* Desoxypipradrol
Desoxypipradrol, also known as 2-diphenylmethylpiperidine (2-DPMP), is a drug developed by Ciba in the 1950s which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI).
Chemistry
Desoxypipradrol is closely related on a structural lev ...
* Difemetorex
References
Stimulants 2-Benzylpiperidines {{nervous-system-drug-stub