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5-Methylethylone
5-Methylethylone (5-methyl-βk-MDEA, 5ME) is an empathogen, stimulant and psychedelic drug of the amphetamine, phenethylamine, and cathinone chemical classes. It is structurally related to ethylone, a novel designer drug. Relatively little data exists about the pharmacological properties, metabolism, and toxicity of 5-methylethylone, though it has been sold as a designer drug. Legal status United States 5-Methylethylone is unscheduled in the United States, but it is not currently approved by the Food and Drug Administration for human consumption. The state of Vermont lists it as a regulated drug. Vermont Health Regulations See also * 5-Methyl-MDA * |
Cathinones
Substituted cathinones, which include some stimulants and entactogens, are derivatives of cathinone. They feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon, along with additional substitutions. Cathinone occurs naturally in the plant khat whose leaves are chewed as a recreational drug. List of substituted cathinones The derivatives may be produced by substitutions at four locations of the cathinone molecule: * R1 = hydrogen, or any combination of one or more alkyl, alkoxy, alkylenedioxy, haloalkyl or halide substituents * R2 = hydrogen or any alkyl group * R3 = hydrogen, any alkyl group, or incorporation in a cyclic structure * R4 = hydrogen, any alkyl group, or incorporation in a cyclic structure The following table displays notable derivatives that have been reported: Legality On 2 April 2010, the Advisory Council on the Misuse of Drugs in the UK announced that a broad structure-based b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eutylone
Eutylone (also known as β-keto-1,3-benzodioxolyl-''N''-ethylbutanamine, bk-EBDB, and ''N''-ethylbutylone) is a stimulant and empathogenic compound developed in the 1960s, which is classified as a designer drug. It was first reported to the EMCDDA in 2014 and became widespread internationally in 2019-2020 following bans on the related compound ephylone. It is not a natural, but a synthetic cathinone. In 2021, eutylone was the most common cathinone identified by the Drug Enforcement Administration in the United States. Legal status Sweden's public health agency suggested classifying eutylone as a hazardous substance, on September 25, 2019. In the United States Eutylone is considered a schedule 1 controlled substance as a positional isomer of Pentylonehttps://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf See also * 5-Methylethylone * Butylone * Ethyl-J * Ethylone * Ephylone ''N''-Ethylpentylone (β-keto-ethylbenzodioxolylpentanamine, βk-ethyl-K, βk-E ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ephylone
''N''-Ethylpentylone (β-keto-ethylbenzodioxolylpentanamine, βk-ethyl-K, βk-EBDP, ephylone) is a substituted cathinone and stimulant drug which was developed in the 1960s. It has been reported as a novel designer drug in several countries including the United Kingdom, South Africa, New Zealand, the United States, and Australia.Pill testing at festivals has hidden benefits that could reduce drug taking Claudia Long, , 2018-07-20 In 2018, ''N''-ethylpentylone was the most common drug of the cathinone class to be identified in |
Ethylone
Ethylone, also known as 3,4-methylenedioxy-''N''-ethylcathinone (MDEC, βk-MDEA), is a recreational designer drug classified as an entactogen, stimulant, and psychedelic of the phenethylamine, amphetamine, and cathinone chemical classes. It is the β-keto analogue of MDEA ("Eve"). Ethylone has only a short history of human use and is reported to be less potent than its relative methylone. In the United States, it began to be found in cathinone products in late 2011. Very little data exists about the pharmacological properties, metabolism, and toxicity of ethylone, and although several ethylone-related deaths have been reported, the cause of death was not due to ingestion of ethylone. Pharmacokinetics Analysis of human and rat urine for the metabolites of bk-amphetamines suggested that ethylone was degraded in the following metabolic steps: # N- deethylation to the primary amine. # Reduction of the keto moiety to the respective alcohol. Legal Status As of October 2015 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
N-Ethylhexylone
''N''-Ethylhexylone is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Poland in August 2019. It is illegal in Taiwan since July 2020, where it had been sold mixed with plant material under the name 彩虹菸 ("Rainbow Tobacco" or "Rainbow Smoke"). See also * 3F-NEH * 4F-PHP * 5-Methylethylone * Ethylone * Eutylone * Ephylone * Isohexylone * MDPV * MDPHP * N-Ethylhexedrone * N-Ethylheptylone ''N''-Ethylheptylone (HEP) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It is a homologue of related drugs such as ethylone, eutylone, ephylone and ''N''-ethylhexylone but with a longer hepty ... References Cathinones Designer drugs Norepinephrine–dopamine reuptake inhibitors {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isohexylone
Isohexylone is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in the United Kingdom in June 2019. See also * Methylone * 5-Methylethylone * Butylone * Desmethylsibutramine * Eutylone * Pentylone * Ephylone * N-Ethylhexylone * α-PHiP * 3F-PiHP * UWA-101 UWA-101 (also known as α-cyclopropyl-MDMA) is a phenethylamine derivative invented by Dr Matthew Piggott at the University of Western Australia, and researched as a potential treatment for Parkinson's disease. Its chemical structure is very sim ... References Cathinones Designer drugs Serotonin-norepinephrine-dopamine releasing agents {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Designer Drugs
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with fewer side effects, and shorter duration (and possibly also because it is easier to apply for patents for new molecules) and were later co-opted for recreational use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human trials, the use of some of these drugs may result i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methylone
Methylone (also known as "3,4-methylenedioxy-''N''-methylcathinone", "MDMC", "βk-MDMA" and by the slang term "M1") is an empathogen and stimulant psychoactive drug. It is a member of the substituted amphetamine, substituted cathinone and substituted methylenedioxyphenethylamine classes. Methylone is the substituted cathinone analog of MDMA and the 3,4-methylenedioxy analog of methcathinone. The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the β position of the phenethylamine core, forming a ketone group. Methylone was first synthesized by the chemists Peyton Jacob III and Alexander Shulgin in 1996 for potential use as an antidepressant. Methylone has been sold for recreational use, taking advantage of the absence of legal prohibition of this compound in many countries . Effects Resemblance to MDMA Methylone substitutes for MDMA in rats trained to discriminate MDMA from saline. Methyl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychedelic Drug
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence'' Sometimes, they are called classic hallucinogens, serotonergic hallucinogens, or serotonergic psychedelics, and the term ''psychedelics'' is used more broadly to include all hallucinogens; this article uses the narrower definition of ''psychedelics''. Psychedelics cause specific psychological, visual, and auditory changes, and often a substantially altered state of consciousness.Leary, Timothy; Metzner, Ralph (1964). ''The Psychedelic Experience: A Manual Based on The Tibetan Book of the Dead'' Psychedelic states are often compared to meditative, psychodynamic or transcendental types of alterations of mind. The "classical" psychedelics, the psy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amphetamine
Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used as a recreational drug. Amphetamine was discovered in 1887 and exists as two enantiomers: levoamphetamine and dextroamphetamine. ''Amphetamine'' properly refers to a specific chemical, the racemic free base, which is equal parts of the two enantiomers in their pure amine forms. The term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic performance enhancer and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant. It is a prescription drug in many countries, and unauthorized possession and distribution of amphetamine are often tightly controlled due to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Butylone
Butylone, also known as β-keto-''N''-methylbenzodioxolylbutanamine (βk-MBDB), is an entactogen, psychedelic, and stimulant psychoactive drug of the phenethylamine chemical class. It is the β-keto (substituted cathinone) analogue of MBDB and the substituted methylenedioxyphenethylamine analogue of buphedrone. History Butylone was first synthesized by Koeppe, Ludwig and Zeile which is mentioned in their 1967 paper. It remained an obscure product of academia until 2005 when it was sold as a designer drug. Butylone shares the same relationship to MBDB as methylone does to MDMA ("Ecstasy"). Formal research on this chemical was first conducted in 2009, when it was shown to be metabolised in a similar manner to related drugs like methylone. Synthesis Butylone can be synthesized in a laboratory via the following route: 3,4-methylenedioxybutyrophenone dissolved in dichloromethane to bromine gives 3′,4′-methylenedioxy-2-bromobutyrophenone. This product was then dissolved in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
