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4-TM
Thiomescaline (TM) is a pair of lesser-known psychedelic drugs with the molecular formula C11H17NO2S. 3-TM and 4-TM are analogs of mescaline in which an oxygen atom has been replaced with a sulfur atom. They were first synthesized by Alexander Shulgin and described in his book '' PiHKAL''. Very little data exists on the pharmacological properties, metabolism, and toxicity of thiomescaline. 3-TM ''Dosage'': 60–100 mg ''Duration'': 8–12 hours ''Effects'': strong open and closed-eye visuals, synesthesia upon listening to music, +++ on the Shulgin Rating Scale 4-TM ''Dosage'': 20–40 mg ''Duration'': 10–15 hours ''Effects'': LSD-like imagery and effects See also * Thioescaline Thioescaline (TE) is a pair of lesser-known psychedelic drugs with the chemical formula C12H19NO2S. They structural analogs of escaline in which an oxygen atom has been replaced with a sulfur atom. They were first synthesized by Alexander Shulgin ... References {{reflist Psyche ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-TM
Thiomescaline (TM) is a pair of lesser-known psychedelic drugs with the molecular formula C11H17NO2S. 3-TM and 4-TM are analogs of mescaline in which an oxygen atom has been replaced with a sulfur atom. They were first synthesized by Alexander Shulgin and described in his book '' PiHKAL''. Very little data exists on the pharmacological properties, metabolism, and toxicity of thiomescaline. 3-TM ''Dosage'': 60–100 mg ''Duration'': 8–12 hours ''Effects'': strong open and closed-eye visuals, synesthesia upon listening to music, +++ on the Shulgin Rating Scale 4-TM ''Dosage'': 20–40 mg ''Duration'': 10–15 hours ''Effects'': LSD-like imagery and effects See also * Thioescaline Thioescaline (TE) is a pair of lesser-known psychedelic drugs with the chemical formula C12H19NO2S. They structural analogs of escaline in which an oxygen atom has been replaced with a sulfur atom. They were first synthesized by Alexander Shulgin ... References {{reflist Psyche ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3-TM
Thiomescaline (TM) is a pair of lesser-known psychedelic drugs with the molecular formula C11H17NO2S. 3-TM and 4-TM are analogs of mescaline in which an oxygen atom has been replaced with a sulfur atom. They were first synthesized by Alexander Shulgin and described in his book '' PiHKAL''. Very little data exists on the pharmacological properties, metabolism, and toxicity of thiomescaline. 3-TM ''Dosage'': 60–100 mg ''Duration'': 8–12 hours ''Effects'': strong open and closed-eye visuals, synesthesia Synesthesia (American English) or synaesthesia (British English) is a perceptual phenomenon in which stimulation of one sensory or cognitive pathway leads to involuntary experiences in a second sensory or cognitive pathway. People who re ... upon listening to music, +++ on the Shulgin Rating Scale 4-TM ''Dosage'': 20–40 mg ''Duration'': 10–15 hours ''Effects'': LSD-like imagery and effects See also * Thioescaline References {{reflist Psych ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychedelics, Dissociatives And Deliriants
Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorized as either being psychedelics, dissociatives, or deliriants. However, certain hallucinogens such as Fly agaric as well as other gabaergic hallucinogenics are more often considered to technically be hypnotics, therefore indicating another separate subcategory of drugs which can substantially alter visual perception. Etymology The word ''hallucinogen'' is derived from the word ''hallucination''. The term ''hallucinate'' dates back to around 1595–1605, and is derived from the Latin ''hallūcinātus'', the past participle of ''(h)allūcināri'', meaning "to wander in the mind." Characteristics Leo Hollister gave five criteria for classifying a drug as hallucinogenic.Glennon RA. Classical drugs: an introductory overview. In Lin GC and Gle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Structural Analogs
A structural analog (analogue in modern traditional English; Commonwealth English), also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced with other atoms, groups, or substructures. A structural analog can be imagined to be formed, at least theoretically, from the other compound. Structural analogs are often isoelectronic. Despite a high chemical similarity, structural analogs are not necessarily functional analogs and can have very different physical, chemical, biochemical, or pharmacological properties. In drug discovery, either a large series of structural analogs of an initial lead compound are created and tested as part of a structure–activity relationship study or a database is screened for structural analogs of a lead compound. Chemical analogues of ille ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mescaline
Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological sources It occurs naturally in several species of cacti. It is also found in small amounts in certain members of the bean family, Fabaceae, including ''Acacia berlandieri''. However those claims concerning ''Acacia'' species have been challenged and have been unsupported in any additional analysis. History and use Peyote has been used for at least 5,700 years by Indigenous peoples of the Americas in Mexico. Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from Peru to Ecuador. While religious and ceremonial peyote use was widespread in the Aztec empire and northern M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexander Shulgin
Alexander Theodore "Sasha" Shulgin (June 17, 1925 – June 2, 2014) was an American medicinal chemist, biochemist, organic chemist, pharmacologist, psychopharmacologist, and author. He is credited with introducing 3,4-methylenedioxymethamphetamine (MDMA, commonly known as "ecstasy") to psychologists in the late 1970s for psychopharmaceutical use and for the discovery, synthesis and personal bioassay of over 230 psychoactive compounds for their psychedelic and entactogenic potential. In 1991 and 1997, he and his wife Ann Shulgin compiled the books '' PiHKAL'' and ''TiHKAL'' (standing for ''Phenethylamines'' and ''Tryptamines I Have Known And Loved''), from notebooks that extensively described their work and personal experiences with these two classes of psychoactive drugs. Shulgin performed seminal work into the descriptive synthesis of many of these compounds. Some of Shulgin's noteworthy discoveries include compounds of the 2C* family (such as 2C-B) and compounds of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synesthesia
Synesthesia (American English) or synaesthesia (British English) is a perceptual phenomenon in which stimulation of one sensory or cognitive pathway leads to involuntary experiences in a second sensory or cognitive pathway. People who report a lifelong history of such experiences are known as synesthetes. Awareness of synesthetic perceptions varies from person to person. In one common form of synesthesia, known as grapheme–color synesthesia or color–graphemic synesthesia, letters or numbers are perceived as inherently colored. In spatial-sequence, or number form synesthesia, numbers, months of the year, or days of the week elicit precise locations in space (''e.g.,'' 1980 may be "farther away" than 1990), or may appear as a three-dimensional map (clockwise or counterclockwise). Synesthetic associations can occur in any combination and any number of senses or cognitive pathways. Little is known about how synesthesia develops. It has been suggested that synesthesia dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shulgin Rating Scale
The Shulgin Rating Scale (or "quantitative potency scale") is a simple scale for reporting the subjective effect of psychoactive substances at a given dosage, and at a given time. The system was developed for research purposes by the American biochemist Alexander Shulgin, and published with co-authors Ann Shulgin and Peyton Jacob, III, in a 1986 issue of the journal ''Methods and Findings in Experimental and Clinical Pharmacology''. It was later described in the Shulgins' popular 1991 book ''PIHKAL: A Chemical Love Story''. ''PIHKAL'' Glossary excerpts Usage ''Shulgin Ratings'' typically include three components. An identification of the chemical being ingested, a dosage, and a descriptive narrative including the ratings themselves used to describe various moments in time. The chemical itself must be clearly identified, preferably using chemical nomenclature, as opposed to popular or "street" names. The dosage must be known and communicated, as substances may result in wildly diff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thioescaline
Thioescaline (TE) is a pair of lesser-known psychedelic drugs with the chemical formula C12H19NO2S. They structural analogs of escaline in which an oxygen atom has been replaced with a sulfur atom. They were first synthesized by Alexander Shulgin and reported in his book '' PiHKAL''. Very little is known about their dangers or toxicity. See also * Thiomescaline * TME (psychedelics) * Thiotrisescaline Thiotrisescaline (T-TRIS) is a series of lesser-known phenethylamines prepared as potential Psychedelics, dissociatives and deliriants, psychedelic drugs. There are two isomers, 3-T-TRIS and 4-T-TRIS, each similar in structure to trisescaline with ... References {{reflist Psychedelic phenethylamines Thioethers Methoxy compounds Ethoxy compounds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychedelic Phenethylamines
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence'' Sometimes, they are called classic hallucinogens, serotonergic hallucinogens, or serotonergic psychedelics, and the term ''psychedelics'' is used more broadly to include all hallucinogens; this article uses the narrower definition of ''psychedelics''. Psychedelics cause specific psychological, visual, and auditory changes, and often a substantially altered state of consciousness.Leary, Timothy; Metzner, Ralph (1964). ''The Psychedelic Experience: A Manual Based on The Tibetan Book of the Dead'' Psychedelic states are often compared to meditative, psychodynamic or transcendental types of alterations of mind. The "classical" psychedelics, the psyc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
