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3',4'-Dimethoxy-α-pyrrolidinopentiophenone
3',4'-Dimethoxy-α-pyrrolidinopentiophenone (also known as O-2512, 3,4-dimethoxy-α-PVP, 3,4-DMPV, DMPVP) is a synthetic stimulant drug of the cathinone class that has been sold online as a designer drug. It is a relatively weak inhibitor of serotonin reuptake and has little affinity ''in vitro'' for dopamine or noradrenaline transporters. See also * 4Cl-PVP * 4F-PVP * 4-Et-PVP * α-PBP * α-PHP * α-PPP * α-PVP * α-PVT * MFPVP * MOPVP * MDPV * O-2390 O-2390 (3,4-Dichloro-alpha-PVP, DCPVP) is a recreational designer drug from the substituted cathinone family, which acts as a potent inhibitor of dopamine and noradrenaline reuptake ''in vitro'', with weaker but still significant inhibition of ... * Pyrovalerone References Designer drugs Norepinephrine–dopamine reuptake inhibitors Pyrrolidinophenones Stimulants Propyl compounds {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4Cl-PVP
4-Chloro-''alpha''-pyrrolidinovalerophenone (also known as 4-chloro-''alpha''-pyrrolidinopentiophenone, 4-chloro-α-PVP, 4Cl-PVP, or 4C-PVP) is an emerging recreational designer drug of the pyrrolidinophenone class, similar in structure to ''alpha''-pyrrolidinopentiophenone (α-PVP). The pharmacology and toxicity of this compound is unknown, though it is presumed to be a stimulant drug. In the United States, 4-chloro-α-PVP is a Schedule I Controlled Substance. See also * 3F-PVP * 4-Chloromethcathinone * 4F-PVP * 4-Et-PVP * MFPVP * MOPVP * DMPVP * MDPV * O-2390 * Pyrovalerone * RTI-31 (–)-2β-Carbomethoxy-3β-(4'-chlorophenyl)tropane (RTI-''4229''-31) is a synthetic analog of cocaine that acts as a stimulant. Semi-synthesis of this compound is dependent upon the availability of cocaine starting material. According to the ar ... References Pyrrolidinophenones Designer drugs Serotonin-norepinephrine-dopamine releasing agents Propyl compounds {{DEFAULTSORT ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-Et-PVP
4-Ethyl-alpha-PVP (4-Et-PVP) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Hungary in March 2019. See also * 3F-PVP * 4-EMC * 4-Ethylamphetamine * 4F-PVP * 4Cl-PVP * MOPVP * DMPVP * MDPV * Pyrovalerone * RTI-83 RTI-83 ((–)-2β-carbomethoxy-3β-(4-ethylphenyl)tropane) is a phenyltropane derivative which represents a rare example of an SDRI or serotonin-dopamine reuptake inhibitor, a drug which inhibits the reuptake of the neurotransmitters serotonin ... * 3,4-EtPV (3,4-EthylenPyroValeron) References Pyrrolidinophenones Designer drugs Serotonin-norepinephrine-dopamine releasing agents {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4'-Methoxy-α-pyrrolidinopentiophenone
4'-Methoxy-α-pyrrolidinopentiophenone (also known as O-2417, 4-MeO-α-PVP and MOPVP) is a stimulant drug of the cathinone class that has been sold online as a designer drug. Legal Status As of October 2015 4-MeO-α-PVP is a controlled substance in China. See also * 4Cl-PVP * 4F-PVP * 4-Et-PVP * alpha-Pyrrolidinopentiophenone * 4'-Methoxy-α-pyrrolidinopropiophenone * DMPVP * MDPV Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ingelheim. Its activity at the dopamine tra ... * Pyrovalerone References Designer drugs Norepinephrine–dopamine reuptake inhibitors Pyrrolidinophenones Propyl compounds {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MFPVP
MFPVP (3-Methyl-4-fluoro-α-pyrrolidinovalerophenone) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Sweden in April 2020. See also * 3F-PVP * 4F-PVP * 4F-PHP * 4Cl-PVP * 4-Cl-3-MMC * MOPVP * DMPVP * MDPV * O-2390 * Pyrovalerone (Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371) is a psychoactive drug with stimulant effects via acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is used for the clinical treatment of chronic fatigue or letharg ... References Pyrrolidinophenones Designer drugs {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrochloride
In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine). An alternative name is chlorhydrate, which comes from French. An archaic alternative name is muriate, derived from hydrochloric acid's ancient name: muriatic acid. Uses Converting amines into their hydrochlorides is a common way to improve their water solubility, which can be desirable for substances used in medications. The European Pharmacopoeia lists more than 200 hydrochlorides as active ingredients in medications. These hydrochlorides, compared to free bases, may more readily dissolve in the gastrointestinal tract and be absorbed into the bloodstream more quickly. Additionally, many hydrochlorides of amines have a longer shelf-life than their respective free bases. Amine hydrochlorides represent latent forms of a more reactive free base. In this regard, formation of an amine hydrochloride confers protection. This eff ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-Pyrrolidinopentiothiophenone
α-Pyrrolidinopentiothiophenone (also known as α-PVT) is a synthetic stimulant of the Substituted cathinone, cathinone class that has been sold online as a designer drug. It is an Structural analog, analogue of Alpha-Pyrrolidinopentiophenone, α-PVP where the Phenyl group, phenyl ring has been replaced by thiophene. α-PVT was first identified in Japan in 2013. Its metabolism has been described in literature. Side effects α-PVT has been shown to possess high cytotoxicity against human cell lines. Legality Sweden's public health agency suggested classifying α-PVT as hazardous substance on November 10, 2014. α-PVT is a controlled substance in China. α-PVT is illegal in Switzerland . See also * alpha-Pyrrolidinopropiophenone, α-Pyrrolidinopropiophenone (α-PPP) * Alpha-Pyrrolidinobutiophenone, α-Pyrrolidinobutiophenone (α-PBP) * Alpha-Pyrrolidinohexiophenone, α-Pyrrolidinohexiophenone (α-PHP) * Methiopropamine * Naphyrone (O-2482) * Pyrovalerone (O-2371) * Thiopro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Designer Drugs
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with fewer side effects, and shorter duration (and possibly also because it is easier to apply for patents for new molecules) and were later co-opted for recreational use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human trials, the use of some of these drugs may result i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrovalerone
(Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371) is a psychoactive drug with stimulant effects via acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is used for the clinical treatment of chronic fatigue or lethargy and as an anorectic or appetite suppressant for weight loss purposes. It was developed in the late 1960s and has since been used in France and several other European countries, and although pyrovalerone is still occasionally prescribed, it is used infrequently due to problems with abuse and dependence. It is closely related on a structural level to a number of other stimulants, such as α-PVP, MDPV and prolintane (Promotil, Katovit). Side effects of pyrovalerone include anorexia or loss of appetite, anxiety, fragmented sleep or insomnia, and trembling, shaking, or muscle tremors. Withdrawal following abuse upon discontinuation often results in depression. The ''R''-enantiomer of pyrovalerone is devoid of activity. See also * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
O-2390
O-2390 (3,4-Dichloro-alpha-PVP, DCPVP) is a recreational designer drug from the substituted cathinone family, which acts as a potent inhibitor of dopamine and noradrenaline reuptake ''in vitro'', with weaker but still significant inhibition of serotonin reuptake. See also * 3F-PVP * 4F-PVP * 4Cl-PVP * 3,4-DCMP * Cilobamine * Dichloropane * LR-5182 * MDPV * MFPVP * Naphyrone * Sertraline * TH-PVP TH-PVP is a substituted cathinone derivative which has been sold as a designer drug. It was first identified by a forensic laboratory in Hungary in 2015, but has subsequently been found in numerous other countries around the world including Spai ... References Pyrrolidinophenones Designer drugs Serotonin-norepinephrine-dopamine releasing agents {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MDPV
Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ingelheim. Its activity at the dopamine transporter is six times stronger than at the norepinephrine transporter and it is virtually inactive at the serotonin transporter. MDPV remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug. In the USA, products containing MDPV and labeled as bath salts were sold as recreational drugs in gas stations, similar to the marketing for Spice and K2 as incense, until it was banned in 2011. Appearance The hydrochloride salt exists as a very fine crystalline powder; it is hygroscopic and thus tends to form clumps, resembling something like powdered sugar. Its color can range from pure white to a yellowish-tan and has a slight odor that strengthens as it colors. Impurities are likely to consist of either pyrr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |