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4-Et-PVP
4-Ethyl-alpha-PVP (4-Et-PVP) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Hungary in March 2019. See also * 3F-PVP * 4-EMC * 4-Ethylamphetamine * 4F-PVP * 4Cl-PVP * MOPVP * DMPVP * MDPV * Pyrovalerone * RTI-83 RTI-83 ((–)-2β-carbomethoxy-3β-(4-ethylphenyl)tropane) is a phenyltropane derivative which represents a rare example of an SDRI or serotonin-dopamine reuptake inhibitor, a drug which inhibits the reuptake of the neurotransmitters serotonin ... * 3,4-EtPV (3,4-EthylenPyroValeron) References Pyrrolidinophenones Designer drugs Serotonin-norepinephrine-dopamine releasing agents {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Cathinone
Substituted cathinones, which include some stimulants and entactogens, are derivatives of cathinone. They feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon, along with additional substitutions. Cathinone occurs naturally in the plant khat whose leaves are chewed as a recreational drug. List of substituted cathinones The derivatives may be produced by substitutions at four locations of the cathinone molecule: * R1 = hydrogen, or any combination of one or more alkyl, alkoxy, alkylenedioxy, haloalkyl or halide substituents * R2 = hydrogen or any alkyl group * R3 = hydrogen, any alkyl group, or incorporation in a cyclic structure * R4 = hydrogen, any alkyl group, or incorporation in a cyclic structure The following table displays notable derivatives that have been reported: Legality On 2 April 2010, the Advisory Council on the Misuse of Drugs in the UK announced that a broad structure-based ba ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-EMC
4-Ethylmethcathinone (4-EMC) is a recreational designer drug of the stimulant and entactogen class. It is a structural isomer of 4-MEC and 3,4-DMMC. It has been identified in many countries around the world, initially in Europe but was first found in Australia in 2020. Legal status In the United States 4-EMC is considered a schedule 1 controlled substance as a positional isomer of 4-Methylethcathinone (4-MEC) 4-Ethylmethcathinone is a controlled substance in the US state of Vermont . It is also covered by analogue provisions in many other jurisdictions. See also * 4-Ethylamphetamine * 4-Et-PVP * RTI-83 RTI-83 ((–)-2β-carbomethoxy-3β-(4-ethylphenyl)tropane) is a phenyltropane derivative which represents a rare example of an SDRI or serotonin-dopamine reuptake inhibitor, a drug which inhibits the reuptake of the neurotransmitters serotonin ... References Cathinones Designer drugs Entactogens and empathogens {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4-Ethylamphetamine
4-Ethylamphetamine (4-EA) is a substituted amphetamine derivative which has been sold as a designer drug. It is mainly known as a synthetic intermediate used as a building block to manufacture larger molecules, but 4-EA is closely related in chemical structure to designer drugs such as 4-methylamphetamine and 4-ethylmethcathinone, and is both a synthetic precursor and a metabolite of the 25-NB derivative 4-EA-NBOMe. See also * 25E-NBOMe * 4-Et-PVP * Amfepentorex * DOET * RTI-83 RTI-83 ((–)-2β-carbomethoxy-3β-(4-ethylphenyl)tropane) is a phenyltropane derivative which represents a rare example of an SDRI or serotonin-dopamine reuptake inhibitor, a drug which inhibits the reuptake of the neurotransmitters serotonin ... References Substituted amphetamines {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4Cl-PVP
4-Chloro-''alpha''-pyrrolidinovalerophenone (also known as 4-chloro-''alpha''-pyrrolidinopentiophenone, 4-chloro-α-PVP, 4Cl-PVP, or 4C-PVP) is an emerging recreational designer drug of the pyrrolidinophenone class, similar in structure to ''alpha''-pyrrolidinopentiophenone (α-PVP). The pharmacology and toxicity of this compound is unknown, though it is presumed to be a stimulant drug. In the United States, 4-chloro-α-PVP is a Schedule I Controlled Substance. See also * 3F-PVP * 4-Chloromethcathinone * 4F-PVP * 4-Et-PVP * MFPVP * MOPVP * DMPVP * MDPV * O-2390 * Pyrovalerone * RTI-31 (–)-2β-Carbomethoxy-3β-(4'-chlorophenyl)tropane (RTI-''4229''-31) is a synthetic analog of cocaine that acts as a stimulant. Semi-synthesis of this compound is dependent upon the availability of cocaine starting material. According to the ar ... References Pyrrolidinophenones Designer drugs Serotonin-norepinephrine-dopamine releasing agents Propyl compounds {{DEFAULTSORT ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
4'-Methoxy-α-pyrrolidinopentiophenone
4'-Methoxy-α-pyrrolidinopentiophenone (also known as O-2417, 4-MeO-α-PVP and MOPVP) is a stimulant drug of the cathinone class that has been sold online as a designer drug. Legal Status As of October 2015 4-MeO-α-PVP is a controlled substance in China. See also * 4Cl-PVP * 4F-PVP * 4-Et-PVP * alpha-Pyrrolidinopentiophenone * 4'-Methoxy-α-pyrrolidinopropiophenone * DMPVP * MDPV Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ingelheim. Its activity at the dopamine tra ... * Pyrovalerone References Designer drugs Norepinephrine–dopamine reuptake inhibitors Pyrrolidinophenones Propyl compounds {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3',4'-Dimethoxy-α-pyrrolidinopentiophenone
3',4'-Dimethoxy-α-pyrrolidinopentiophenone (also known as O-2512, 3,4-dimethoxy-α-PVP, 3,4-DMPV, DMPVP) is a synthetic stimulant drug of the cathinone class that has been sold online as a designer drug. It is a relatively weak inhibitor of serotonin reuptake and has little affinity ''in vitro'' for dopamine or noradrenaline transporters. See also * 4Cl-PVP * 4F-PVP * 4-Et-PVP * α-PBP * α-PHP * α-PPP * α-PVP * α-PVT * MFPVP * MOPVP * MDPV * O-2390 O-2390 (3,4-Dichloro-alpha-PVP, DCPVP) is a recreational designer drug from the substituted cathinone family, which acts as a potent inhibitor of dopamine and noradrenaline reuptake ''in vitro'', with weaker but still significant inhibition of ... * Pyrovalerone References Designer drugs Norepinephrine–dopamine reuptake inhibitors Pyrrolidinophenones Stimulants Propyl compounds {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pyrovalerone
(Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371) is a psychoactive drug with stimulant effects via acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is used for the clinical treatment of chronic fatigue or lethargy and as an anorectic or appetite suppressant for weight loss purposes. It was developed in the late 1960s and has since been used in France and several other European countries, and although pyrovalerone is still occasionally prescribed, it is used infrequently due to problems with abuse and dependence. It is closely related on a structural level to a number of other stimulants, such as α-PVP, MDPV and prolintane (Promotil, Katovit). Side effects of pyrovalerone include anorexia or loss of appetite, anxiety, fragmented sleep or insomnia, and trembling, shaking, or muscle tremors. Withdrawal following abuse upon discontinuation often results in depression. The ''R''-enantiomer of pyrovalerone is devoid of activity. See also * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Designer Drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. Designer drugs include psychoactive substances that have been designated by the European Union as new psychoactive substances (NPS) as well as analogs of performance-enhancing drugs such as designer steroids. Some of these were originally synthesized by academic or industrial researchers in an effort to discover more potent derivatives with fewer side effects, and shorter duration (and possibly also because it is easier to apply for patents for new molecules) and were later co-opted for recreational use. Other designer drugs were prepared for the first time in clandestine laboratories. Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human trials, the use of some of these drugs may result i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have Sympathomimetic drug, sympathomimetic effects. Stimulants are widely used throughout the world as prescription medicines as well as without a prescription (either legally or Prohibition (drugs), illicitly) as performance-enhancing substance, performance-enhancing or recreational drug use, recreational drugs. Among narcotics, stimulants produce a noticeable crash or ''Comedown (drugs), comedown'' at the end of their effects. The most frequently prescribed stimulants as of 2013 were lisdexamfetamine (Vyvanse), methylphenidate (Ritalin), and amphetamine (Adderall). It was estimated in 2015 that the percentage of the world population that had used cocaine during a year was 0.4%. For the category "amphetamines and p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
3F-PVP
3-Fluoro-alpha-PVP (3F-PVP) is a recreational designer drug from the substituted cathinone family with stimulant effects, which first appeared on the illicit market in around 2018. It is illegal in Finland. See also * 3-Fluoroamphetamine * 3-Fluoromethamphetamine * 3-Fluoroethamphetamine * 3-Fluoromethcathinone * 3-Fluorophenmetrazine * 3F-NEH * 3F-PiHP * 4F-PVP * 4Cl-PVP 4-Chloro-''alpha''-pyrrolidinovalerophenone (also known as 4-chloro-''alpha''-pyrrolidinopentiophenone, 4-chloro-α-PVP, 4Cl-PVP, or 4C-PVP) is an emerging recreational designer drug of the pyrrolidinophenone class, similar in structure to ''al ... * 4F-PHP References Pyrrolidinophenones Designer drugs Serotonin-norepinephrine-dopamine releasing agents {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MDPV
Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI). It was first developed in the 1960s by a team at Boehringer Ingelheim. Its activity at the dopamine transporter is six times stronger than at the norepinephrine transporter and it is virtually inactive at the serotonin transporter. MDPV remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug. In the USA, products containing MDPV and labeled as bath salts were sold as recreational drugs in gas stations, similar to the marketing for Spice and K2 as incense, until it was banned in 2011. Appearance The hydrochloride salt exists as a very fine crystalline powder; it is hygroscopic and thus tends to form clumps, resembling something like powdered sugar. Its color can range from pure white to a yellowish-tan and has a slight odor that strengthens as it colors. Impurities are likely to consist of either pyrr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
