100,000 Genomes Project
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100,000 Genomes Project
The 100,000 Genomes Project is a now-completed UK Government project managed by Genomics England that is sequencing whole genomes from National Health Service patients. The project is focusing on rare diseases, some common types of cancer, and infectious diseases. Participants give consent for their genome data to be linked to information about their medical condition and health records. The medical and genomic data is shared with researchers to improve knowledge of the causes, treatment and care of diseases. History The project was first announced by UK Prime Minister David Cameron in December 2012. The Government set up a new company Genomics England to oversee the project with the plan to focus on rare diseases, cancer and infectious diseases announced by Health Secretary Jeremy Hunt in July 2013. The project was also made possible by the National Institute for Health and Care Research (NIHR), NHS England, Public Health England and Health Education England. In 2015 Northe ...
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National Institute For Health And Care Research
The National Institute for Health and Care Research (NIHR) is the British government’s major funder of clinical, public health, social care and translational research. With a budget of over £1.2 billion in 2020–21, its mission is to "improve the health and wealth of the nation through research". The NIHR was established in 2006 under the government's Best Research for Best Health strategy, and is funded by the Department of Health and Social Care. As a research funder and research partner of the NHS, public health and social care, the NIHR complements the work of the Medical Research Council. NIHR focuses on translational research (translating discoveries from the laboratory to the clinic), clinical research and applied health and social care research. History The NIHR (originally named National Institute for Health Research) was created in April 2006 under the government's health research strategy, Best Research for Best Health. This strategy outlined the direction that ...
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Public Health England
Public Health England (PHE) was an executive agency of the Department of Health and Social Care in England which began operating on 1 April 2013 to protect and improve health and wellbeing and reduce health inequalities. Its formation came as a result of the reorganisation of the National Health Service (NHS) in England outlined in the Health and Social Care Act 2012. It took on the role of the Health Protection Agency, the National Treatment Agency for Substance Misuse and a number of other health bodies. It was an executive agency of the Department of Health and Social Care, and a distinct delivery organisation with operational autonomy. On 29 March 2021, the UK Government announced that PHE would be disbanded and that its public health functions would be transferred, in proposals to reform public health structures. From 1 October 2021, PHE's health protection functions were formally transferred into the UK Health Security Agency (UKHSA), while its health improvement functions ...
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Congenica
The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust. It is located on the Wellcome Genome Campus by the village of Hinxton, outside Cambridge. It shares this location with the European Bioinformatics Institute. It was established in 1992 and named after double Nobel Laureate Frederick Sanger. It was conceived as a large scale DNA sequencing centre to participate in the Human Genome Project, and went on to make the largest single contribution to the gold standard sequence of the human genome. From its inception the institute established and has maintained a policy of data sharing, and does much of its research in collaboration. Since 2000, the institute expanded its mission to understand "the role of genetics in health and disease". The institute now employs around 900 people and engages in five main areas of research: C ...
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Oxford University Hospitals NHS Trust
Oxford University Hospitals NHS Foundation Trust is an English teaching hospital and part of the Shelford Group. It is one of the UK's largest teaching hospitals and one of the largest hospitals in Europe. The trust is made up of four hospitals – the John Radcliffe Hospital (which includes the Children's Hospital, West Wing, Eye Hospital, Heart Centre and Women's Centre), the Churchill Hospital and the Nuffield Orthopaedic Centre, all located in Oxford, and the Horton General Hospital in Banbury, north Oxfordshire. As well as the four main hospitals, the trust also provides services in four community hospitals across Oxfordshire including Thame, Wallingford, Wantage and Witney. The services offered at these community hospitals are fairly basic and differ from hospital to hospital. Wantage community hospital is also accompanied by Wantage health centre whereby additional health services are provided by the trust. Other clinics and health centres serviced by the trust in Oxford ...
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Moorfields Eye Hospital NHS Foundation Trust
Moorfields Eye Hospital NHS Foundation Trust is an NHS foundation trust which runs Moorfields Eye Hospital. The Trust employs over 1,700 people. Over 24,000 ophthalmic operations are carried out and over 300,000 patients are seen by the hospital each year. The trust delivers its services from its main site on City Road and through its distributed network of over 20 other 'satellite' clinics located in other parts of London and the South East including Ealing, Teddington, Tooting, Mile End, Harrow and Tottenham. Backing up NHS Direct, Moorfields has a specialised ophthalmic telephone advice line, Moorfields Direct. Moorfields was one of the first NHS foundation trusts, and is a founder member of the UCLPartners, an academic health science centre. It plans to move its main hospital from the current City Road site to St Pancras Hospital in Camden. This will cost £352 million and it is planned to be operational in 2025–26. Commercial activities In addition to its NHS cl ...
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Guy's Hospital
Guy's Hospital is an NHS hospital in the borough of Southwark in central London. It is part of Guy's and St Thomas' NHS Foundation Trust and one of the institutions that comprise the King's Health Partners, an academic health science centre. It is a large teaching hospital and is, with St Thomas' Hospital and King's College Hospital, the location of King's College London GKT School of Medical Education. The hospital's Tower Wing (originally known as Guy's Tower) was, when built in 1974, the tallest hospital building in the world, standing at with 34 floors. The tower was overtaken as the world's tallest healthcare-related building by The Belaire in New York City in 1988. As of June 2019, the Tower Wing, which remains one of the tallest buildings in London, is the world's fifth-tallest hospital building. History The hospital dates from 1721, when it was founded by philanthropist Thomas Guy, who had made a fortune as a printer of Bibles and greatly increased it by speculat ...
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Great Ormond Street Hospital
Great Ormond Street Hospital (informally GOSH or Great Ormond Street, formerly the Hospital for Sick Children) is a children's hospital located in the Bloomsbury area of the London Borough of Camden, and a part of Great Ormond Street Hospital for Children NHS Foundation Trust. The hospital is the largest centre for child heart surgery in the UK and one of the largest centres for heart transplantation in the world. In 1962 they developed the first heart and lung bypass machine for children. With children's book author Roald Dahl, they developed an improved shunt valve for children with hydrocephalus, and non-invasive (percutaneous) heart valve replacements. They did the first UK clinical trials of the rubella vaccine, and the first bone marrow transplant and gene therapy for severe combined immunodeficiency.Breakthroughs It is closely associated with University College London (UCL) and in partnership with the UCL Great Ormond Street Institute of Child Health, which is adjace ...
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Central Manchester University Hospitals NHS Foundation Trust
Central Manchester University Hospital NHS Foundation Trust, established in 2009, ran eight hospitals in Manchester and Trafford: Manchester Royal Infirmary, Royal Manchester Children's Hospital, Saint Mary's Hospital, Manchester, Manchester Royal Eye Hospital and University Dental Hospital of Manchester in Manchester, and Trafford General Hospital, Altrincham Hospital and Stretford Memorial Hospital in Trafford. It is a teaching hospital of the School of Medicine, University of Manchester and one of the Shelford Group. Sir Mike Deegan was Chief Executive from 2001. He was reckoned by the Health Service Journal to be the 54th most influential person in the English NHS in 2015. History The Infirmary, Manchester Convalescent Home, St Mary's, the Royal Eye Hospital, the Dental Hospital and the Foot Hospital in Manchester were entitled ''The United Manchester Hospitals'' when they were taken into the National Health Service in 1948 and run by one hospital management committee. M ...
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Newcastle Upon Tyne NHS Foundation Trust
Newcastle upon Tyne Hospitals NHS Foundation Trust is one of the Shelford Group of University Teaching Hospitals and an NHS Foundation Trust. It provides acute medical services in Newcastle upon Tyne, England, at Royal Victoria Infirmary and Freeman Hospital, the Campus for Ageing and Vitality (the former Newcastle General Hospital site), Newcastle Dental Hospital, Newcastle Fertility Centre and the Northern Genetics Service. The Private Finance Initiative scheme at the Trust is a 38-year deal with Healthcare Support (Newcastle) Ltd, a special purpose vehicle formed in 2005 involving the Commonwealth Bank of Australia, Equion and Laing O'Rourke, Interserve and Innisfree Ltd. In 2014, there was a dispute between the Trust and Laing O'Rourke over two clinical office buildings. Performance The Trust was highlighted by NHS England as having 4 (the most at any Trust) of the 148 reported never events in the period from April to September 2013. The trust was rated outstanding by ...
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University College London Partners
UCLPartners is an academic health science centre located in London, England. It is the largest academic health science centre in the world, treats more than 1.5 million patients each year, has a combined annual turnover of around £2 billion and includes around 3,500 scientists, senior researchers and consultants. The members of UCLPartners include Barts Health NHS Trust, Great Ormond Street Hospital for Children NHS Trust, Moorfields Eye Hospital NHS Foundation Trust, Queen Mary University of London, Royal Free London NHS Foundation Trust, University College London (UCL), The Tavistock and Portman NHS Foundation Trust and University College London Hospitals NHS Foundation Trust. History In July 2007 the then Health Minister Lord Darzi recommended the establishment of a number of academic health science centres in the UK. Great Ormond Street Hospital for Children NHS Trust, Moorfields Eye Hospital NHS Foundation Trust, Royal Free Hampstead NHS Trust (now Royal Free London NHS F ...
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Cambridge University Hospitals
Cambridge University Hospitals NHS Foundation Trust is a British public sector healthcare provider located in Cambridge, England. It was established on 4 November 1992 as Addenbrooke's National Health Service Trust, and authorised as an NHS foundation trust under its current name on 1 July 2004. The Trust provides healthcare for people in the Cambridge area, in eastern England, and specialist services such as transplantation, treatment of rare cancers and neurological intensive care for a much wider area. It is located on the Cambridge Biomedical Campus and runs Addenbrooke's Hospital and the Rosie Hospital. It is a member of the Shelford Group, an informal organisation of ten leading English university teaching hospitals. Roland Sinker is the current chief executive; Sinker joined the Trust in 2015 moving from King's College Hospital NHS Foundation Trust in London where he was acting CEO. He had previously been the Chief Operating Officer from 2009 to 2015. Research Cambridg ...
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Wales
Wales ( cy, Cymru ) is a Countries of the United Kingdom, country that is part of the United Kingdom. It is bordered by England to the Wales–England border, east, the Irish Sea to the north and west, the Celtic Sea to the south west and the Bristol Channel to the south. It had a population in 2021 of 3,107,500 and has a total area of . Wales has over of coastline and is largely mountainous with its higher peaks in the north and central areas, including Snowdon (), its highest summit. The country lies within the Temperateness, north temperate zone and has a changeable, maritime climate. The capital and largest city is Cardiff. Welsh national identity emerged among the Celtic Britons after the Roman withdrawal from Britain in the 5th century, and Wales was formed as a Kingdom of Wales, kingdom under Gruffydd ap Llywelyn in 1055. Wales is regarded as one of the Celtic nations. The Conquest of Wales by Edward I, conquest of Wales by Edward I of England was completed by 1283, th ...
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