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1,2-Dithiole
In organosulfur chemistry, a 1,2-dithiole is a type of heterocycle. The parent of this class of compounds is 1,2-dithiacyclopentene. The anticancer drug oltipraz Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomac ... is a dithiole. : See also * Dithiolium salt References {{DEFAULTSORT:Dithiole, 1,2- Dithioles ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dithiolium Salt
Dithiolium salts are compounds of the formula RC)3S2sup>+X− (R = H, alkyl, aryl, etc.). These salts consist of a planar organic cation with a variety of anions such as halides. The five-membered ring cations are observed in either of two isomers, 1,2- and 1,3-dithiolium cations. These cations differ with respect to the relative positions of the pair of sulfur atoms. Both isomers feature a planar ring, which is aromatic owing to the presence of 6π electrons. For example, the 1,2-ditholium ring can be represented as an allyl cation of the three carbons, with each sulfur atom donating one of its lone pairs of electrons to give a total of three pairs. Preparation, occurrence, reactions 1,2-Dithiolium cations have been prepared from 1,3-diketones by treatment with H2S and oxidants such as bromine. : 1,3-Dithiolium cations are often prepared by alkylation of the corresponding unsaturated dithio- or trithiocarbonates: :{{Chem2, (RC)2S2CE + R'+ -> RC)2S2CER' The analogo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organosulfur Chemistry
Organosulfur compounds are organic compounds that contain sulfur. They are often associated with foul odors, but many of the sweetest compounds known are organosulfur derivatives, e.g., saccharin. Nature abounds with organosulfur compounds—sulfur is vital for life. Of the 20 common amino acids, two (cysteine and methionine) are organosulfur compounds, and the antibiotics penicillin and sulfa drugs both contain sulfur. While sulfur-containing antibiotics save many lives, sulfur mustard is a deadly chemical warfare agent. Fossil fuels, coal, petroleum, and natural gas, which are derived from ancient organisms, necessarily contain organosulfur compounds, the removal of which is a major focus of oil refineries. Sulfur shares the chalcogen group with oxygen, selenium, and tellurium, and it is expected that organosulfur compounds have similarities with carbon–oxygen, carbon–selenium, and carbon–tellurium compounds. A classical chemical test for the detection of sulfur compound ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oltipraz
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radical In chemistry, a superoxide is a compound that contains the superoxide ion, which has the chemical formula . The systematic name of the anion is dioxide(1−). The reactive oxygen ion superoxide is particularly important as the product of th ..., which can be toxic. References Antiparasitic agents Pyrazines Dithioles Thiocarbonyl compounds Antineoplastic drugs {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oltipraz
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radical In chemistry, a superoxide is a compound that contains the superoxide ion, which has the chemical formula . The systematic name of the anion is dioxide(1−). The reactive oxygen ion superoxide is particularly important as the product of th ..., which can be toxic. References Antiparasitic agents Pyrazines Dithioles Thiocarbonyl compounds Antineoplastic drugs {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
