Oltipraz is an organosulfur compound belonging to the
dithiolethione class.
It acts as a
schistosomicide and has been shown in
rodent
Rodents (from Latin , 'to gnaw') are mammals of the order Rodentia (), which are characterized by a single pair of continuously growing incisors in each of the upper and lower jaws. About 40% of all mammal species are rodents. They are n ...
models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue.
Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity.
Oltipraz has also been shown to generate
superoxide radical
In chemistry, a superoxide is a compound that contains the superoxide ion, which has the chemical formula . The systematic name of the anion is dioxide(1−). The reactive oxygen ion superoxide is particularly important as the product of th ...
, which can be toxic.
References
Antiparasitic agents
Pyrazines
Dithioles
Thiocarbonyl compounds
Antineoplastic drugs
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