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Schistosomicide
A schistosomicide is a drug used to combat schistosomiasis. List Examples listed in MeSH include: * amoscanate * arteether * artemether * chloroxylenol * hycanthone * lucanthone * metrifonate * niridazole * oltipraz * oxamniquine * praziquantel * stibophen Stibophen is an anthelmintic originally developed by Bayer that is used as a treatment for schistosomiasis by intramuscular injection. It is classified as a trivalent antimony compound. Brand names include Fouadin/Fuadin (named in honor of Fua ... See also * Schistosomiasis vaccine References Further reading * {{DEFAULTSORT:Drugs used to treat schistosomiasis Antiparasitic agents Lists of drugs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Niridazole
Niridazole is a schistosomicide. It is used to treat schistosomiasis, the helmintic disease caused by certain flatworms (trematodes) from the genus '' Schistosoma'' (formerly ''Bilharzia''). It is also known by its trade name Ambilhar. It is usually given as tablets. Niridazole has central nervous system toxicity and can cause dangerous side effects, such as hallucinations. Also, it may cause allergic reactions in sensitive people. However, it is one of the most effective schistosomicide drugs. It has recently also been investigated for use in the treatment of periodontitis. __TOC__ Mechanism of action Niridazole is rapidly concentrated in the parasite and inhibits oogenesis and spermatogenesis. The compound also inhibits the phosphofructokinase enzyme, leading to glycogen depletion and hepatic shift The liver is a major organ only found in vertebrates which performs many essential biological functions such as detoxification of the organism, and the synthesis of prot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hycanthone
Hycanthone is the schistosomicide approved by the FDA in 1975. It is a metabolite of lucanthone. Hycanthone interferes with parasite nerve function, resulting in paralysis and death. This agent also intercalates into DNA and inhibits RNA synthesis ''in vitro'' and shows potential antineoplastic activity. Anti-schistosomal activity Hycanthone is shown to be an effective inhibitor of acetylcholinesterase (AChE) from '' Schistosoma mansoni'', but is less potential against AChE from mammalian origin. This might come from differences in the configuration of active center between schistosome and mammalian AChE enzymes. Hycanthone is shown to intercalates into DNA and inhibit RNA synthesis ''in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called " test-tube experiments", these studies in biology ...''. A growing body of evidence h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oltipraz
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radical In chemistry, a superoxide is a compound that contains the superoxide ion, which has the chemical formula . The systematic name of the anion is dioxide(1−). The reactive oxygen ion superoxide is particularly important as the product of th ..., which can be toxic. References Antiparasitic agents Pyrazines Dithioles Thiocarbonyl compounds Antineoplastic drugs {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Schistosomiasis
Schistosomiasis, also known as snail fever, bilharzia, and Katayama fever, is a disease caused by parasitic flatworms called schistosomes. The urinary tract or the intestines may be infected. Symptoms include abdominal pain, diarrhea, bloody stool, or blood in the urine. Those who have been infected for a long time may experience liver damage, kidney failure, infertility, or bladder cancer. In children, it may cause poor growth and learning difficulty. The disease is spread by contact with fresh water contaminated with the parasites. These parasites are released from infected freshwater snails. The disease is especially common among children in developing countries, as they are more likely to play in contaminated water. Other high-risk groups include farmers, fishermen, and people using unclean water during daily living. It belongs to the group of helminth infections. Diagnosis is by finding eggs of the parasite in a person's urine or stool. It can also be confirmed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Subject Headings
Medical Subject Headings (MeSH) is a comprehensive controlled vocabulary for the purpose of indexing journal articles and books in the life sciences. It serves as a thesaurus that facilitates searching. Created and updated by the United States National Library of Medicine (NLM), it is used by the MEDLINE/PubMed article database and by NLM's catalog of book holdings. MeSH is also used by ClinicalTrials.gov registry to classify which diseases are studied by trials registered in ClinicalTrials. MeSH was introduced in the 1960s, with the NLM's own index catalogue and the subject headings of the Quarterly Cumulative Index Medicus (1940 edition) as precursors. The yearly printed version of MeSH was discontinued in 2007; MeSH is now available only online. It can be browsed and downloaded free of charge through PubMed. Originally in English, MeSH has been translated into numerous other languages and allows retrieval of documents from different origins. Structure MeSH vocabulary is div ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amoscanate
Amoscanate (INN), also known as nithiocyamine, is an experimental anthelmintic agent of the aryl isothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans, and is also highly active against hookworm infection. However, significant liver toxicity was seen in lab animals at higher doses. The ether analogue of amoscanate, nitroscanate, is used in veterinary medicine as an anthelmintic. Amoscanate was developed by Ciba. Retrieved on September 10, 2008 through Google Book Search Google Books (previously known as Google Book Search, Google Print, and by its code-name Project Ocean) is a service from Google Inc. that searches the full text of books and magazines that Google has scanned, converted to text using optical .... References Anthelmintics Isothiocyanates {{antimicrobial-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arteether
Artemotil (INN; also known as β-arteether), is a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant ''Plasmodium falciparum'' malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Chinese plant ''Artemisia annua ''Artemisia annua'', also known as sweet wormwood, sweet annie, sweet sagewort, annual mugwort or annual wormwood (), is a common type of wormwood native to temperate Asia, but naturalized in many countries including scattered parts of North Am ...''. It is currently only used as a second line drug in severe cases of malaria. References Antimalarial agents Ethers Organic peroxides Sesquiterpenes Trioxanes {{antimicrobial-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Artemether
Artemether is a medication used for the treatment of malaria. The injectable form is specifically used for severe malaria rather than quinine. In adults, it may not be as effective as artesunate. It is given by injection in a muscle. It is also available by mouth in combination with lumefantrine, known as artemether/lumefantrine. Artemether causes relatively few side effects. An irregular heartbeat may rarely occur. While there is evidence that use during pregnancy may be harmful in animals, there is no evidence of concern in humans. The World Health Organization (WHO) therefore recommends its use during pregnancy. It is in the artemisinin class of medication. Artemether has been studied since at least 1981, and been in medical use since 1987. It is on the World Health Organization's List of Essential Medicines. Medical uses Artemether is an antimalarial drug for uncomplicated malaria caused by '' P. falciparum'' (and chloroquine-resistant '' P. falciparum'') or chlor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chloroxylenol
Chloroxylenol, also known as ''para''-chloro-''meta''-xylenol (PCMX), is an antiseptic and disinfectant which is used for skin disinfection, and together with alcohol for cleaning surgical instruments. It is also used within a number of household disinfectants and wound cleaners. It is thought to act by disrupting microbial cell walls and inactivating cellular enzymes, and is less effective than some other available agents. It is available as a liquid. History Chloroxylenol was first made in 1927. It is on the World Health Organization's List of Essential Medicines. It is sold in a number of formulations and under a number of brand names, including ''Dettol''. Soon after it was created ''parachlorometaxylenol'' was then called ''PCMX'', but this was thought to be a poor name and it was renamed ''Dettol''. Then in 1932 it was marketed in Britain and in India. It had a white on green bottle with a white sword depicted. Properties Side effects are generally few but can include sk ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lucanthone
Lucanthone is a drug used to treat parasitic diseases such as bilharziasis and schistosomiasis It is a prodrug and is converted to the active metabolite hycanthone. Mechanism of action Hycanthone binds to acetylcholine receptors in the worm and results in increased sensitivity to stimulation by 5-HT causing increase in motility, paired worms are separated and reproduction is stopped. It causes damage of the integument and vitelline duct In the human embryo, the vitelline duct, also known as the vitellointestinal duct, the yolk stalk, the omphaloenteric duct, or the omphalomesenteric duct, is a long narrow tube that joins the yolk sac to the midgut lumen of the developing fetus. .... References Antineoplastic drugs Thioxanthones {{antineoplastic-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metrifonate
Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor. It is a prodrug which is activated non-enzymatically into the active agent dichlorvos. It is used as an insecticide. According to the US Environmental Protection Agency trichlorfon has been used on golf course turf, home lawns, non-food contact areas of food and meat processing plants, ornamental shrubs and plants, and ornamental and baitfish ponds. Used to control caterpillars, white grubs, mole crickets, cattle lice, sod webworms, leaf miners, stink bugs, flies, ants, cockroaches, earwigs, crickets, diving beetle, water scavenger beetle, water boatman backswimmer, water scorpions, giant water bugs and pillbugs. After reregistration, a number of its uses were voluntarily restricted, and currently, it is used in nonfood areas to control flies, roaches, and ants among other pets. Outdoors it is used on ornamental plants, golf courses, and lawn grass to treat lepidopteran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxamniquine
Oxamniquine, sold under the brand name Vansil among others, is a medication used to treat schistosomiasis due to '' Schistosoma mansoni''. Praziquantel, however, is often the preferred treatment. It is given by mouth and used as a single dose. Common side effects include sleepiness, headache, nausea, diarrhea, and reddish urine. It is typically not recommended during pregnancy, if possible. Seizures may occur and therefore caution is recommended in people with epilepsy. It works by causing paralysis of the parasitic worms. It is in the anthelmintic family of medications. Oxamniquine was first used medically in 1972. It is on the World Health Organization's List of Essential Medicines. It is not commercially available in the United States. It is more expensive than praziquantel. Medical uses Oxamniquine is used for treatment of schistosomiasis. According to one systematic review, praziquantel is the standard treatment for '' S. mansoni'' infections and oxamniquine also app ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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