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Thiotepa

Clinical dataTrade namesTepadinaOther namesN,N',N''(-triethylenethiophosphoramide, INN, Thiotepa, Tepadina, TepyluteAHFS/Drugs.comMonographMedlinePlusa682821License dataUSDailyMed: ThiotepaPregnancycategoryAU: DRoutes ofadministrationIntravenous, , intravesicalATC codeL01AC01 (WHO) Legal statusLegal statusAU:S4 (Prescription only)CA: ℞-onlyUK:POM (Prescription only)US:℞-onlyEU: Rx-onlyPharmacokinetic dataMetabolismLiver (CYP2B6, CYP3A)MetabolitesPhase 1: Tetraethylenepentamine (tepa) Phase 2: Thiotepa-mercapturateElimination half-life1.5–4.1 hoursExcretionKidney6 hours for thiotepa8 hours for TEPAIdentifiersIUPAC name1,1′,1″-PhosphorothioyltriaziridineCAS Number52-24-4PubChemCID5453IUPHAR/BPS7622DrugBankDB04572ChemSpider5254UNII905Z5W3GKHKEGGD00583ChEMBLChEMBL671CompTox Dashboard(EPA)DTXSID0021339ECHA InfoCard100.000.124Chemical and physical dataFormulaC6H12N3PSMolar mass189.22 g·mol3D model (JSmol)Interactive imageMelting point51.5 °C (124.7 °F)Solubility in water0.19 g/mL (water, 25 °C) Freely soluble in alcohol, diethyl ether and chloroform mg/mL (20 °C)SMILESS=P(N1CC1)(N2CC2)N3CC3InChIInChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2Key:FOCVUCIESVLUNU-UHFFFAOYSA-N(verify)Thiotepa (N,N',N''(-triethylenethiophosphoramide, INN), sold under the brand name Tepadina among others, is an anti-cancer medication.

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