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Nifedipine

Clinical dataPronunciationTrade namesAdalat, Procardia, othersAHFS/Drugs.comMonographMedlinePlusa684028License dataUSDailyMed: NifedipinePregnancycategoryAU: CRoutes ofadministrationBy mouth, topicalDrug classCalcium channel blocker (dihydropyridine)ATC codeC08CA05 (WHO) Legal statusLegal statusCA: ℞-onlyUS:℞-onlyPharmacokinetic dataBioavailability45-56%Protein binding92-98%MetabolismGastrointestinal, LiverElimination half-life2 hoursExcretionKidneys: >50%, bile duct: 5-15%IdentifiersIUPAC name3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylateCAS Number21829-25-4PubChemCID4485IUPHAR/BPS2514DrugBankDB01115ChemSpider4330UNIII9ZF7L6G2LKEGGD00437ChEBICHEBI:7565ChEMBLChEMBL193CompTox Dashboard(EPA)DTXSID2025715ECHA InfoCard100.040.529Chemical and physical dataFormulaC17H18N2O6Molar mass346.339 g·mol3D model (JSmol)Interactive imageMelting point173 °C (343 °F)SMILESO=C(OC)\C1=C(\N/C(=C(/C(=O)OC)C1c2ccccc2[N+]([O-])=O)C)CInChIInChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3Key:HYIMSNHJOBLJNT-UHFFFAOYSA-N(verify)Nifedipine ( ), sold under the brand name Procardia among others, is a calcium channel blocker medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor.

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