Explore relationships

Methylphenidate

Central nervous system stimulantPharmaceutical compoundClinical dataPronunciation Trade namesRitalin, Concerta, othersOther namesMPHAHFS/Drugs.comMonographMedlinePlusa682188License dataUS DailyMed: MethylphenidatePregnancycategoryAU: DDependenceliabilityPhysical: NonePsychological: ModerateAddictionliabilityModerateRoutes ofadministrationMedical: Oral, transdermalRecreational: Oral, insufflation, sublingual, rectal, intravenousDrug classStimulant; Norepinephrine–dopamine reuptake inhibitor (NDRI)ATC codeN06BA04 (WHO) Legal statusLegal statusAU: S8 (Controlled drug)BR: Class A3 (Psychoactive drugs)CA: Schedule IIIDE: Anlage III (Special prescription form required)NZ: Class B2 -authority required UK: Class BUS: Schedule IIUN: Psychotropic Schedule IIEU: Rx-onlySE: Förteckning II MX: Controlled (estupefaciente)Pharmacokinetic dataBioavailabilityOral: ~30% (range: 11–52%)Protein binding~15% (±5%) binds to plasma proteinsMetabolismLiver (80%) mostly CES1-mediatedMetabolitesα-phenyl-2-piperidine acetic acid (ritalinic acid)Onset of action~20–60 minutes, depending on formulationElimination half-life2—3 hoursDuration of actionIR dosing: 3–4 hoursER dosing: 8–12 hoursExcretionUrine (90%)IdentifiersIUPAC nameMethyl phenyl(piperidin-2-yl)acetateCAS Number20748-11-2PubChemCID4158IUPHAR/BPS7236DrugBankDB00422ChemSpider4015UNII207ZZ9QZ49KEGGD04999ChEBICHEBI:6887ChEMBLChEMBL796CompTox Dashboard(EPA)DTXSID5023299ECHA InfoCard100.003.662Chemical and physical dataFormulaC14H19NO2Molar mass233.311 g·mol3D model (JSmol)Interactive imageMelting point74 °C (165 °F) Boiling point136 °C (277 °F) SMILESCOC(=O)C(c1ccccc1)C1CCCCN1InChIInChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3Key:DUGOZIWVEXMGBE-UHFFFAOYSA-N (verify)Methylphenidate, sold under the brand names Ritalin and Concerta, among others, is a central nervous system (CNS) stimulant used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.

Use + to expand a branch. Click a topic name to open its summary.