ZBP1

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 20: 57.6 – 57.62 MbChr 2: 173.05 – 173.06 MbPubMed searchWikidata

Z-DNA-binding protein 1 (also known as DNA-dependent activator of IFN-regulatory factors (DAI) and DLM-1) is a mammalian intracellular protein that acts as an innate immune sensor. ZBP1 senses left-handed (Z-form) double-helical Z-DNA and Z-RNA from pathogens (acting as pathogen-associated molecular patterns, PAMPs) or from endogenous sources (acting as damage-associated molecular patterns, DAMPs). ZBP1 associates with receptor-interacting protein kinase 3 (RIPK3) to engage caspases and the NLRP3inflammasome to form a PANoptosome and initiate PANoptosis, a form of inflammatory programmed cell death.

Z-DNA binding protein 1 should not be confused with β-actin zipcode-binding protein 1 (also known as ZBP1), an alias for the mRNA-binding protein IGF2BP1.