UBA2

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 19: 34.43 – 34.47 MbChr 7: 33.84 – 33.87 MbPubMed searchWikidata

SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2gene (previously UBLE1B).

Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins.