Tranylcypromine

Tranylcypromine, sold under the brand name Parnate among others, is a non-selective and irreversiblemonoamine oxidase inhibitor (MAOI). It is used primarily as an antidepressant in the treatment of major depressive disorder, including treatment-resistant depression. Along with phenelzine and isocarboxazid, tranylcypromine is one of the classic irreversible, non-selective MAOIs used in modern psychiatric practice.

Tranylcypromine is also known as trans-2-phenylcyclopropyl-1-amine and is formed pro forma from the cyclization of amphetamine's isopropylamineside chain. As a result, it is classified structurally as a substituted phenethylamine and amphetamine, or more specifically as a phenylcyclopropylamine.