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Topic summary

Tetrahydrofuran

Tetrahydrofuran
Names Preferred IUPAC name
Oxolane
Systematic IUPAC name
1,4-Epoxybutane
1-Oxacyclopentane
Other names
  • Tetrahydrofuran
  • THF
  • 1,4-Butylene oxide
  • Cyclotetramethylene oxide fraction
  • Furanidin
  • Tetra-methylene oxide
  • Oxolane
Identifiers
3D model (JSmol)
Abbreviations THF ChEBI
ChEMBL
ChemSpider
ECHA InfoCard100.003.389
RTECS number
  • LU5950000
UNII
  • InChI=1S/C4H8O/c1-2-4-5-3-1/h1-4H2
    Key: WYURNTSHIVDZCO-UHFFFAOYSA-N
  • InChI=1/C4H8O/c1-2-4-5-3-1/h1-4H2
    Key: WYURNTSHIVDZCO-UHFFFAOYAI
  • C1CCOC1
Properties C4H8OMolar mass72.107 g·mol Appearance Colorless liquid OdorEther-like Density0.8876 g/cm at 20 °C, liquid Melting point−108.4 °C (−163.1 °F; 164.8 K) Boiling point66 °C (151 °F; 339 K) MiscibleVapor pressure132 mmHg at 20 °C 1.4073 at 20 °C Viscosity0.48 cP at 25 °C Structure Envelope1.63 D (gas) Hazards GHS labelling: DangerH225, H302, H319, H335, H351P210, P280, P301+P312+P330, P305+P351+P338, P370+P378, P403+P235NFPA 704 (fire diamond)
2
3
2
Flash point−14 °C (7 °F; 259 K) 215 °C (419 °F; 488 K) Explosive limits2–11.8% Lethal dose or concentration (LD, LC):
  • 1650 mg/kg (rat, oral)
  • 2300 mg/kg (mouse, oral)
  • 2300 mg/kg (guinea pig, oral)
21000 ppm (rat, 3 h) NIOSH (US health exposure limits):
PEL (Permissible)
TWA 200 ppm (590 mg/m)
REL (Recommended)
TWA 200 ppm (590 mg/m) ST 250 ppm (735 mg/m)
IDLH (Immediate danger)
2000 ppm Related compounds
Related heterocycles
Furan
Pyrrolidine
Dioxane
Related compounds
Diethyl etherSupplementary data page Tetrahydrofuran (data page)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Tetrahydrofuran (THF), or oxolane, is an organic compound with the formula (CH2)4O. The compound is classified as heterocyclic compound, specifically a cyclic ether. It is a colorless, water-miscible organic liquid with low viscosity. It is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. It is an isomer of another solvent, butanone.

Wikipedia source