Topic summary
SREBP
Extracted from the Wikipedia article Sterol regulatory element-binding protein.
Isoforms
- SREBP-1 expression produces two different isoforms, SREBP-1a and -1c. These isoforms differ in their first exons owing to the use of different transcriptional start sites for the SREBP-1 gene. SREBP-1c was also identified in rats as ADD-1. SREBP-1c is responsible for regulating the genes required for de novo lipogenesis.
- SREBP-2 regulates the genes of cholesterol metabolism.