Topic summary
RU-28253
RU-28253, also known as 5-MeO-THPI, is a non-selectiveserotonin receptor agonist of the tryptamine, 5-methoxytryptamine, and tetrahydropyridinylindole families. It is a tetrahydropyridylindole and a conformationally constrainedanalogue of 5-MeO-DMT.
The drug shows high affinity for the serotonin5-HT1A receptor (Ki = 5.7nM) and lower affinity for the serotonin 5-HT2A receptor (Ki = 230nM). Its affinities for these receptors were higher than those of dimethyltryptamine (DMT). RU-28253 is described as a potent agonist of the serotonin 5-HT1 and 5-HT2 receptors, including of the serotonin 5-HT1B receptor, and is also an agonist of the serotonin 5-HT4 receptor.
RU-28253 was first described in the scientific literature by 1983.