RPTOR

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 17: 80.54 – 80.97 MbChr 11: 119.49 – 119.79 MbPubMed searchWikidata

Regulatory-associated protein of mTOR also known as raptor or KIAA1303 is an adapter protein that is encoded in humans by the RPTORgene. The RPTOR protein is a component of the protein complex mTORC1, a nutrient sensor that promotes cell growth and anabolic reactions in response to nutrients or growth factors. Inside of mTORC1, RPTOR has two major known adaptor functions. In particular, it interacts with Rag GTPases (RRAGA, RRAGB, RRAGC and/or ), recruiting the complex to lysosome membranes, and also binds to TOS motif-containing proteins, and directs them to the complex’s phosphorylating domain. Two mRNAs from the gene have been identified that encode proteins of 1335 (isoform 1) and 1177 (isoform 2) amino acids long.