P2Y12

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 3: 151.34 – 151.38 MbChr 3: 59.12 – 59.17 MbPubMed searchWikidata

P2Y₁₂ is a chemoreceptor for adenosine diphosphate (ADP) that belongs to the G_i class of a group of G protein-coupled (GPCR) purinergic receptors. This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridinenucleotides. The P2Y₁₂ receptor is involved in platelet aggregation and is thus a biological target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

In the field of purinergic signaling, the P2Y₁₂protein on the periphery is found mainly but not exclusively on the surface of bloodplatelets, and is an important regulator in blood clotting. In the central nervous system, this receptor has been found expressed exclusively on microglia, where it is necessary for physiological and pathological microglial actions, such as monitoring neuronal functions and microglial neuroprotection.