NLRP12

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 19: 53.79 – 53.82 MbChr 7: 3.27 – 3.3 MbPubMed searchWikidata

NOD-like receptor|Nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain (PYD)-containing protein 12 (NLRP12; also known as NACHT, LRR and PYD domains-containing protein 12 or NALP12) is a protein that in humans is encoded by the NLRP12gene.

NLRP12 is a cytoplasmic innate immune sensor belonging to the NLRP (NALP) subfamily of the larger CATERPILLER protein family. It participates in regulation of inflammatory signaling and may promote assembly of multiprotein signaling complexes including inflammasomes and PANoptosomes in a context-dependent manner.