Topic summary
Mitotic
Extracted from the Wikipedia article Mitosis.
Mitotic recombination
Mitotic cells irradiated with X-rays in the G1 phase of the cell cycle repair recombinogenic DNA damages primarily by recombination between homologous chromosomes. Mitotic cells irradiated in the G2 phase repair such damages preferentially by sister-chromatid recombination. Mutations in genes encoding enzymes employed in recombination cause cells to have increased sensitivity to being killed by a variety of DNA damaging agents. These findings suggest that mitotic recombination is an adaptation for repairing DNA damages including those that are potentially lethal.