Midodrine

Midodrine, sold under the brand name Proamatine among others, is an antihypotensive medication used to treat orthostatic hypotension (low blood pressure when standing) and urinary incontinence. It is taken by mouth.

Side effects of midodrine include hypertension (high blood pressure), paresthesia, itching (pruritus), goose bumps, chills, urinary urgency, urinary retention, and urinary frequency. Midodrine is a prodrug of its active metabolitedesglymidodrine. This metabolite acts as a selectiveagonist of the α₁-adrenergic receptor. This in turn results in vasoconstriction and increased blood pressure.

Midodrine was discovered by 1971 and was introduced for medical use in the United States in 1996.