Macrogol

Macrogol is the international nonproprietary name used for polyethylene glycol (PEG) as a medication ingredient. It is usually followed by a number indicating the average molecular weight, indicating the length of the polymer of the specific molecule in use. Macrogol is used as a laxative to treat constipation in children and adults. It is orally administered, with a resultant bowel movement typically occurring within a few days. A much larger dose of Macrogol is administered to clear the bowels, as preparation prior to a colonoscopy; the onset of the laxative effect is more rapid at this dosage, with onset of action typically occurring within an hour and lingering effects lasting for up to a few days. Small amounts of Macrogol are also occasionally used similarly to , as an excipient.

Macrogol side effects may include increased flatulence, abdominal pain, and nausea. Rare but serious side effects may include an abnormal heartbeat, seizures, and kidney problems. Moderate usage appears to be safe during pregnancy. It is classified as an osmotic laxative: It works by increasing the amount of water in the stool.

Macrogol came into use as a bowel prep in 1980 and was approved for medical use in the United States in 1999. It is available as a generic medication and over the counter. In 2023, Macrogol was the 196th most commonly prescribed medication in the United States, with more than 2million prescriptions. It is also formulated together with electrolytes. In 2023, Macrogol with electrolytes was the 273rd most commonly prescribed medication in the United States, with more than 800,000 prescriptions.