Topic summary
MX1
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1gene.
In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virusinfection. Furthermore, the human orthologue MxA is a major host determinant for influenza viruses of animal origin. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.