Topic summary
LSZ
LSZ, also known as lysergic acid 2,4-dimethylazetidide or as LA-Azetidide (LA-Az), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is taken orally.
The drug acts as a non-selectiveserotonin receptor agonist, including of the serotonin5-HT2A receptor. It also interacts with dopamine receptors. The compound is a close analogue of LSD that has been modified at the amide to be more rigid and to have three diastereomers. LA-SS-Az, the (S,S)- isomer, is the most potent and similar isomer to LSD, and is the typically employed form of LSZ. LA-SS-Az and the other isomers of LSZ produce psychedelic-like effects in animals.
LSZ was first described in the scientific literature by David E. Nichols and colleagues in 2002. It was developed as a tool for studying psychedelic interactions with the serotonin 5-HT2A receptor and followed the earlier unstable compound LA-Aziridine developed by Nichols and Robert Oberlender. LSZ, under the name "diazedine", may have been produced on a small scale by the LSD manufacturers William Leonard Pickard and Gordon Todd Skinner around the year 2000. It was first definitely encountered as a novel designer drug in 2013 and then became a popular psychedelic. LSZ is a controlled substance in several European countries.