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Topic summary

Guaiacol

Guaiacol
Names Preferred IUPAC name
2-Methoxyphenol
Other names
o-Methoxyphenol
O-Methylcatechol
2-Hydroxyanisole
Pyroguaiac acid
Pyrocatechol monomethyl ether
1-hydroxy-2-methoxybenzene
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
DrugBank
ECHA InfoCard100.001.786EC Number
  • 201-964-7
KEGG
UNII
  • InChI=1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3
    Key: LHGVFZTZFXWLCP-UHFFFAOYSA-N
  • InChI=1/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3
    Key: LHGVFZTZFXWLCP-UHFFFAOYAI
  • COc1ccccc1O
Properties C7H8O2Molar mass124.14 g/mol Appearance colorless oil or crystalline solid OdorCharacteristic sweet odor Density1.112 g/cm, liquid
1.129 g/cm, crystals Melting point26–29 °C (79–84 °F; 299–302 K) Boiling point204–206 °C (399–403 °F; 477–479 K) 23.3 g/L (25 °C) Solubility in carbon tetrachlorideSoluble log P1.32 Vapor pressure0.103 mmHg (25 °C) 1.2×10 atm-cu m/mol (25 °C) Acidity (pKa) 9.98 1.5429 (20 °C) Hazards GHS labelling: WarningH302, H315, H319P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, P501Flash point60 °C (140 °F; 333 K) Lethal dose or concentration (LD, LC): 520 mg/kg (rat, oral)
170 mg/kg (mouse, intravenous)
4600 mg/kg (rabbit, skin) 900 mg/kg (guinea pig, subcutaneous)
1250 mg/kg (rabbit, subcutaneous) 7570 mg/m (mouse) Related compounds Mequinol
3-Methoxyphenol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Guaiacol () is an organic compound with the formula C6H4(OH)(OCH3). It is a phenolic compound containing a methoxy functional group. Guaiacol appears as a viscous colorless oil, although aged or impure samples are often yellowish. It occurs widely in nature and is a common product of the pyrolysis of wood.

Wikipedia source