GRIA4

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 11: 105.61 – 105.98 MbChr 9: 4.42 – 4.8 MbPubMed searchWikidata

Glutamate receptor 4 is a protein that in humans is encoded by the GRIA4gene.

This gene is a member of a family of L-glutamate-gated ion channels that mediate fast synaptic excitatory neurotransmission. These channels are also responsive to the glutamate agonist, alpha-amino-3-hydroxy-5-methyl-4-isoxazolpropionate (AMPA). Some haplotypes of this gene show a positive association with schizophrenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Like the other AMPA receptor subunits, GluA4 occurs as flip and flop spliced variant. In addition, GluA4 CTD long and short isoforms exist, and presumably an ATD-only isoform (433 aa).