Dipivefrine

Dipivefrine, or dipivefrin, also known as epinephrine pivalate and sold under the brand name Propine among others, is a sympathomimeticmedication which is used in the treatment of open-angle glaucoma. It is available as a 0.1% ophthalmicsolution (eye drop).

Side effects of dipivefrine include local eye reactions among others. Dipivefrine is a prodrug of epinephrine (adrenaline) and hence acts as a non-selectiveadrenergic receptoragonist. It is a substituted phenethylamine and catecholamine and is an ester of epinephrine with much greater fat solubility.

Dipivefrine was first described by 1975. It is widely marketed throughout the world. However, it is no longer available in the United States.