Calreticulin

More reference expression dataBioGPSEnsemblUniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)Chr 19: 12.94 – 12.94 MbChr 8: 85.57 – 85.57 MbPubMed searchWikidata

Calreticulin (CRT), also known as CALR, calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60), is a protein that in humans is encoded by the CALRgene.

Calreticulin is a multifunctional soluble protein that binds Caions (a second messenger in signal transduction), rendering them inactive. The Ca is bound with low affinity, but high capacity, and can be released on a signal (see inositol trisphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum and is considered an ER resident protein.

The term mobilferrin is considered to be the same as calreticulin by some sources.